Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Fertility Potential is Compromised in 20% to 25% of Boys with Nonsyndromic Cryptorchidism Despite Orchiopexy within the First Year of Life

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Reply by Authors

    Publikation: Bidrag til tidsskriftKommentar/debatForskning

  2. Active surveillance for localized prostate cancer. Nationwide, observational study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Androgen Receptor Targeted Treatments of Prostate Cancer: 35 Years of Progress with Antiandrogens

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Sexual function in a nationwide cohort of 2260 testicular cancer survivors after 17 years follow-up

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Richter's transformation in patients with chronic lymphocytic leukaemia: a Nationwide Epidemiological Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Postnatal germ cell development in cryptorchid boys

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Review of injection techniques for spermatogonial stem cell transplantation

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. CENTRAL PRECOCIOUS PUBERTY IN TWO BOYS WITH PRADER-WILLI SYNDROME ON GROWTH HORMONE TREATMENT

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Laparoscopy to Assist Surgical Decisions Related to Necrotizing Enterocolitis in Preterm Neonates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

PURPOSE: One of the concerns surrounding cryptorchidism is the risk of impaired fertility. Current guidelines recommend orchiopexy at age 6 to 12 months to optimize fertility outcome. We evaluated the fertility potential of boys with nonsyndromic cryptorchidism who underwent orchiopexy within the recommended age range to clarify the need for eventual supplemental treatment modalities.

MATERIALS AND METHODS: We retrospectively evaluated mini-puberty hormones (follicle-stimulating hormone, luteinizing hormone and inhibin B) and testicular biopsies from boys with cryptorchidism who underwent orchiopexy within the first year of life between 2010 and 2019. We histologically analyzed germ cell number and type A dark spermatogonia number per seminiferous tubule cross-section in relation to normal values.

RESULTS: Of the 333 boys with nonsyndromic cryptorchidism 83 (25%, 21% with bilateral cryptorchidism) had a reduced number of germ cells. A total of 70 boys (21%) had low serum inhibin B, of whom 32 (46%) had a decreased number of germ cells and 23 (33%) had a decreased number of type A dark spermatogonia (p <0.01). Overall, 75 boys (23%) had no type A dark spermatogonia present.

CONCLUSIONS: Despite early and successful orchiopexy, 20% to 25% of boys with cryptorchidism may be at risk for infertility based on hormonal and histological data. Blood test and testicular biopsy are mandatory to identify boys at high risk for infertility, in whom additional treatment modalities and followup may be needed.

OriginalsprogEngelsk
TidsskriftThe Journal of urology
Vol/bind203
Udgave nummer4
Sider (fra-til)832-840
Antal sider9
ISSN0022-5347
DOI
StatusUdgivet - apr. 2020

ID: 58189157