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Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1: a functional GLP-1-renal axis in man

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Asmar, A, Cramon, PK, Simonsen, L, Asmar, M, Sorensen, CM, Madsbad, S, Moro, C, Hartmann, B, Jensen, BL, Holst, JJ & Bülow, J 2019, 'Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1: a functional GLP-1-renal axis in man' The Journal of clinical endocrinology and metabolism, bind 104, nr. 7, s. 2509-2519. https://doi.org/10.1210/jc.2019-00004

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Asmar, Ali ; Cramon, Per K ; Simonsen, Lene ; Asmar, Meena ; Sorensen, Charlotte M ; Madsbad, Sten ; Moro, Cedric ; Hartmann, Bolette ; Jensen, Boye L ; Holst, Jens Juul ; Bülow, Jens. / Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1 : a functional GLP-1-renal axis in man. I: The Journal of clinical endocrinology and metabolism. 2019 ; Bind 104, Nr. 7. s. 2509-2519.

Bibtex

@article{2404076656454da8b86f2eca44bb3cea,
title = "Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1: a functional GLP-1-renal axis in man",
abstract = "PURPOSE: We have previously demonstrated that glucagon-like peptide-1 (GLP-1) does not affect renal hemodynamics or function under baseline conditions in healthy participants and in patients with type 2 diabetes mellitus. However, it is possible that GLP-1 promotes natriuresis under conditions with addition of salt and water to the extracellular fluid. The current study was designed to investigate a possible GLP-1-renal axis, inducing natriuresis in healthy, volume-loaded participants.METHODS: Under fixed sodium intake, eight healthy men were examined twice in random order during a 3-hour infusion of either GLP-1 (1.5 pmol/kg/min) or vehicle together with an intravenous infusion of 0.9{\%} NaCl. Timed urine collections were conducted throughout the experiments. Renal plasma flow (RPF), glomerular filtration rate (GFR), and uptake and release of hormones and ions were measured via Fick's principle.RESULTS: During GLP-1 infusion, urinary sodium and osmolar excretions increased significantly compared with vehicle. Plasma renin levels decreased similarly on both days, whereas angiotensin II (ANG II) levels decreased significantly only during GLP-1 infusion. RPF and GFR remained unchanged on both days.CONCLUSIONS: In volume-loaded participants, GLP-1 induces natriuresis, probably brought about via a tubular mechanism secondary to suppression of ANG II, independent of renal hemodynamics, supporting the existence of a GLP-1-renal axis.",
author = "Ali Asmar and Cramon, {Per K} and Lene Simonsen and Meena Asmar and Sorensen, {Charlotte M} and Sten Madsbad and Cedric Moro and Bolette Hartmann and Jensen, {Boye L} and Holst, {Jens Juul} and Jens B{\"u}low",
note = "Copyright {\circledC} 2019 Endocrine Society.",
year = "2019",
month = "7",
day = "1",
doi = "10.1210/jc.2019-00004",
language = "English",
volume = "104",
pages = "2509--2519",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The/Endocrine Society",
number = "7",

}

RIS

TY - JOUR

T1 - Extracellular fluid volume expansion uncovers a natriuretic action of GLP-1

T2 - a functional GLP-1-renal axis in man

AU - Asmar, Ali

AU - Cramon, Per K

AU - Simonsen, Lene

AU - Asmar, Meena

AU - Sorensen, Charlotte M

AU - Madsbad, Sten

AU - Moro, Cedric

AU - Hartmann, Bolette

AU - Jensen, Boye L

AU - Holst, Jens Juul

AU - Bülow, Jens

N1 - Copyright © 2019 Endocrine Society.

PY - 2019/7/1

Y1 - 2019/7/1

N2 - PURPOSE: We have previously demonstrated that glucagon-like peptide-1 (GLP-1) does not affect renal hemodynamics or function under baseline conditions in healthy participants and in patients with type 2 diabetes mellitus. However, it is possible that GLP-1 promotes natriuresis under conditions with addition of salt and water to the extracellular fluid. The current study was designed to investigate a possible GLP-1-renal axis, inducing natriuresis in healthy, volume-loaded participants.METHODS: Under fixed sodium intake, eight healthy men were examined twice in random order during a 3-hour infusion of either GLP-1 (1.5 pmol/kg/min) or vehicle together with an intravenous infusion of 0.9% NaCl. Timed urine collections were conducted throughout the experiments. Renal plasma flow (RPF), glomerular filtration rate (GFR), and uptake and release of hormones and ions were measured via Fick's principle.RESULTS: During GLP-1 infusion, urinary sodium and osmolar excretions increased significantly compared with vehicle. Plasma renin levels decreased similarly on both days, whereas angiotensin II (ANG II) levels decreased significantly only during GLP-1 infusion. RPF and GFR remained unchanged on both days.CONCLUSIONS: In volume-loaded participants, GLP-1 induces natriuresis, probably brought about via a tubular mechanism secondary to suppression of ANG II, independent of renal hemodynamics, supporting the existence of a GLP-1-renal axis.

AB - PURPOSE: We have previously demonstrated that glucagon-like peptide-1 (GLP-1) does not affect renal hemodynamics or function under baseline conditions in healthy participants and in patients with type 2 diabetes mellitus. However, it is possible that GLP-1 promotes natriuresis under conditions with addition of salt and water to the extracellular fluid. The current study was designed to investigate a possible GLP-1-renal axis, inducing natriuresis in healthy, volume-loaded participants.METHODS: Under fixed sodium intake, eight healthy men were examined twice in random order during a 3-hour infusion of either GLP-1 (1.5 pmol/kg/min) or vehicle together with an intravenous infusion of 0.9% NaCl. Timed urine collections were conducted throughout the experiments. Renal plasma flow (RPF), glomerular filtration rate (GFR), and uptake and release of hormones and ions were measured via Fick's principle.RESULTS: During GLP-1 infusion, urinary sodium and osmolar excretions increased significantly compared with vehicle. Plasma renin levels decreased similarly on both days, whereas angiotensin II (ANG II) levels decreased significantly only during GLP-1 infusion. RPF and GFR remained unchanged on both days.CONCLUSIONS: In volume-loaded participants, GLP-1 induces natriuresis, probably brought about via a tubular mechanism secondary to suppression of ANG II, independent of renal hemodynamics, supporting the existence of a GLP-1-renal axis.

UR - http://www.scopus.com/inward/record.url?scp=85066855746&partnerID=8YFLogxK

U2 - 10.1210/jc.2019-00004

DO - 10.1210/jc.2019-00004

M3 - Journal article

VL - 104

SP - 2509

EP - 2519

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -

ID: 56782711