Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Exposure to passive smoking during adolescence is associated with an increased risk of developing multiple sclerosis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. COVID-19 in people with multiple sclerosis: A global data sharing initiative

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Predictors of treatment outcome in patients with paediatric onset multiple sclerosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Reproductive history of the Danish multiple sclerosis population: A register-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Aggressive multiple sclerosis (2): Treatment

    Publikation: Bidrag til tidsskriftReviewpeer review

  1. Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Determinants of intention to return to donate blood among first-time blood donors in Ghana

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. How donor selection criteria can be evaluated with limited scientific evidence: lessons learned from the TRANSPOSE project

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Putting the spotlight on donation-related risks and donor safety - are we succeeding in protecting donors?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Environmental factors are associated with acquiring multiple sclerosis (MS) particularly in adolescence.

OBJECTIVE: To test for association between MS and exposure to passive smoking at the age of 10-19.

METHODS: A total of 919 patients from the Danish MS Registry and Biobank and 3419 healthy blood donors who had not smoked before the age of 19 were targeted. We analyzed separately for each sex and for those never-smokers (cohort 1) and active smokers above the age of 19 (cohort 2). All participants completed standardized questionnaires about smoking and lifestyle. We matched cases and controls in the ratio of 1:2 by propensity scores discarding unmatchable individuals and used logistic regression adjusted for all covariates and interactions.

RESULTS: After matching, we included 110/213 male cases/controls and 232/377 female case/controls in cohort 1. In cohort 2, the numbers were 160/320 and 417/760, respectively. Among women in cohort 1, the odds ratio (OR) for MS by passive smoking at the age of 10-19 was 1.432 (p = 0.037) but in men it was 1.232 (p = 0.39). Among men in cohort 2, OR was 1.593 (p = 0.022) but among women it was only 1.102 (p = 0.44).

CONCLUSION: Among never smokers, female MS cases were more often than female controls reported with passive smoking between the age of 10 and 19, and among smokers above the age of 19, male MS patients were more often than male controls reported with passive smoking.

OriginalsprogEngelsk
TidsskriftMultiple Sclerosis Journal
Vol/bind27
Udgave nummer2
Sider (fra-til)188-197
Antal sider10
ISSN1352-4585
DOI
StatusUdgivet - feb. 2021

ID: 61696552