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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Ergocalciferol treatment and aspects of mineral homeostasis in patients with chronic kidney disease stage 4-5

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Focus on non-classical effects and possible less side effects of treatment with nutritional vitamin D, raises the expectation of possible benefits from treating chronic kidney disease (CKD) patients with ergocalciferol (vitamin D2). Treatment with 1,25(OH)2 vitamin D (calcitriol) induces elevated fibroblast growth factor 23 (FGF23), while epidemiological studies have found positive effects of nutritional and 25(OH)vitamin D on mortality in CKD. Disturbed mineral homeostasis in CKD is correlated to adverse outcome and cardiovascular mortality. The objective was to examine the possible effects of treatment with high doses of ergocalciferol on parameters of mineral homeostasis in predialysis CKD patients.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical & Laboratory Investigation
Vol/bind73
Udgave nummer2
Sider (fra-til)107-16
Antal sider10
ISSN0036-5513
DOI
StatusUdgivet - mar. 2013

ID: 42333088