Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Endometrial scratch injury with office hysteroscopy before IVF/ICSI: A randomised controlled trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Predictors of emergency cesarean section in women with preexisting diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Routine use of antenatal nonstress tests in pregnant women with diabetes-What is the practice?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. High maternal age at first and subsequent child births in Denmark in the mid-1800s-Letter to the editor

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pelvic organ prolapse surgery after native tissue vault suspension at hysterectomy-A prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. No evidence of association between native tissue vault suspension and risk of pelvic pain or sexual dysfunction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: Endometrial scratch injury (ESI) has been proposed to improve endometrial receptivity and thereby increase implantation rates in assisted reproductive technology (ART) treatment. ESI has been widely incorporated into clinical practice despite inconclusive evidence of its effect on reproductive outcomes. We aimed to assess pregnancy and live birth rates in subfertile women receiving ESI before IVF treatment in comparison to controls.

STUDY DESIGN: This was a randomised controlled trial (RCT) with no blinding of participants, investigators or health care personnel. Women in ART treatment were allocated to either office hysteroscopy with ESI (ESI group) or no intervention (control group). In total 184 women in IVF/ICSI treatment with minimum one previous failed IVF/ICSI cycle, were included in the final analysis. The primary outcome was positive serum hCG (s-hCG). Secondary outcomes were ongoing pregnancy and live birth rate. Only per-protocol analyses were performed as all patients included at one centre had to be excluded. The trial is registered at ClinicalTrials.gov, NCT01743391.

RESULTS: Our results showed a non-significant increase in positive s-hCG (OR 1.23, 95 % CI (0.65-2.33)), ongoing pregnancy (OR 1.52, 95 % CI (0.73-3.17)), and live birth rates (OR 1.69, 95 % CI (0.78-3.64)) per randomised woman between the ESI and the control group.

CONCLUSION: We observed no significant differences in positive s-hCG or other reproductive outcomes in the ESI vs. the control group. While the crude estimates of positive reproductive outcomes were higher in the ESI group, statistical significance was not reached, and the study was not powered to show smaller differences. However, data from this study will be re-evaluated in the context of an individual participant data meta-analysis (IPD-MA) of RCTs on ESI.

OriginalsprogEngelsk
TidsskriftEuropean journal of obstetrics, gynecology, and reproductive biology
Vol/bind252
Sider (fra-til)112-117
Antal sider6
ISSN0028-2243
DOI
StatusUdgivet - 1 sep. 2020

Bibliografisk note

Copyright © 2020 Elsevier B.V. All rights reserved.

ID: 60230318