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Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age

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@article{1909dabccb954ed2a950b6d4a2cd4b53,
title = "Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age",
abstract = "OBJECTIVE: Sleep disturbances and alterations of diurnal endocrine rhythms are associated with increased risk of type 2 diabetes (T2D). We previously showed that young men born small for gestational age (SGA) and with increased risk of T2D have elevated fat and decreased glucose oxidation rates during nighttime. In this study, we investigated whether SGA men have an altered diurnal profile of hormones, substrates and inflammatory markers implicated in T2D pathophysiology compared with matched individuals born appropriate for gestational age (AGA).METHODS: We collected hourly blood samples for 24 h, to measure levels of glucose, free fatty acids (FFA), triglycerides (TG), insulin, C-peptide, leptin, resistin, ghrelin, plasminogen activator inhibitor-1 (PAI-1), incretins (GLP-1 and GIP), and inflammatory markers (TNF-α and IL-6) in 13 young men born SGA and 11 young men born AGA.RESULTS: Repeated measurements analyses were used to analyze the diurnal variations and differences between groups. The SGA subjects had increased 24-h glucose (P=0.03), glucagon (P=0.03) and resistin (P=0.003) levels with no difference in diurnal rhythms compared with AGA controls. We found significant diurnal variations in levels of blood glucose, plasma TG, FFA, insulin, C-peptide, GLP-1, GIP, leptin, visfatin, TNF-α, IL-6 and PAI-1. The variation in FFA levels differed between the groups during the evening. Plasma ghrelin and glucagon levels did not display diurnal variations.CONCLUSIONS: Young men born SGA exhibit elevated 24-h blood glucose, and plasma glucagon and resistin levels with no major differences in diurnal rhythms of these or other key metabolic hormones, substrates or inflammatory markers implicated in the origin of adiposity and T2D.",
keywords = "Blood Glucose, C-Peptide, Circadian Rhythm, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Gestational Age, Ghrelin, Glucagon-Like Peptide 1, Humans, Infant, Newborn, Infant, Small for Gestational Age, Insulin, Interleukin-6, Leptin, Male, Resistin, Triglycerides, Tumor Necrosis Factor-alpha, Young Adult, Journal Article",
author = "Charlotte Br{\o}ns and Saltb{\ae}k, {Pernille N} and Martin Friedrichsen and Yan Chen and Allan Vaag",
note = "{\textcopyright} 2016 European Society of Endocrinology.",
year = "2016",
month = jul,
doi = "10.1530/EJE-16-0177",
language = "English",
volume = "175",
pages = "29--40",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Endocrine and metabolic diurnal rhythms in young adult men born small vs appropriate for gestational age

AU - Brøns, Charlotte

AU - Saltbæk, Pernille N

AU - Friedrichsen, Martin

AU - Chen, Yan

AU - Vaag, Allan

N1 - © 2016 European Society of Endocrinology.

PY - 2016/7

Y1 - 2016/7

N2 - OBJECTIVE: Sleep disturbances and alterations of diurnal endocrine rhythms are associated with increased risk of type 2 diabetes (T2D). We previously showed that young men born small for gestational age (SGA) and with increased risk of T2D have elevated fat and decreased glucose oxidation rates during nighttime. In this study, we investigated whether SGA men have an altered diurnal profile of hormones, substrates and inflammatory markers implicated in T2D pathophysiology compared with matched individuals born appropriate for gestational age (AGA).METHODS: We collected hourly blood samples for 24 h, to measure levels of glucose, free fatty acids (FFA), triglycerides (TG), insulin, C-peptide, leptin, resistin, ghrelin, plasminogen activator inhibitor-1 (PAI-1), incretins (GLP-1 and GIP), and inflammatory markers (TNF-α and IL-6) in 13 young men born SGA and 11 young men born AGA.RESULTS: Repeated measurements analyses were used to analyze the diurnal variations and differences between groups. The SGA subjects had increased 24-h glucose (P=0.03), glucagon (P=0.03) and resistin (P=0.003) levels with no difference in diurnal rhythms compared with AGA controls. We found significant diurnal variations in levels of blood glucose, plasma TG, FFA, insulin, C-peptide, GLP-1, GIP, leptin, visfatin, TNF-α, IL-6 and PAI-1. The variation in FFA levels differed between the groups during the evening. Plasma ghrelin and glucagon levels did not display diurnal variations.CONCLUSIONS: Young men born SGA exhibit elevated 24-h blood glucose, and plasma glucagon and resistin levels with no major differences in diurnal rhythms of these or other key metabolic hormones, substrates or inflammatory markers implicated in the origin of adiposity and T2D.

AB - OBJECTIVE: Sleep disturbances and alterations of diurnal endocrine rhythms are associated with increased risk of type 2 diabetes (T2D). We previously showed that young men born small for gestational age (SGA) and with increased risk of T2D have elevated fat and decreased glucose oxidation rates during nighttime. In this study, we investigated whether SGA men have an altered diurnal profile of hormones, substrates and inflammatory markers implicated in T2D pathophysiology compared with matched individuals born appropriate for gestational age (AGA).METHODS: We collected hourly blood samples for 24 h, to measure levels of glucose, free fatty acids (FFA), triglycerides (TG), insulin, C-peptide, leptin, resistin, ghrelin, plasminogen activator inhibitor-1 (PAI-1), incretins (GLP-1 and GIP), and inflammatory markers (TNF-α and IL-6) in 13 young men born SGA and 11 young men born AGA.RESULTS: Repeated measurements analyses were used to analyze the diurnal variations and differences between groups. The SGA subjects had increased 24-h glucose (P=0.03), glucagon (P=0.03) and resistin (P=0.003) levels with no difference in diurnal rhythms compared with AGA controls. We found significant diurnal variations in levels of blood glucose, plasma TG, FFA, insulin, C-peptide, GLP-1, GIP, leptin, visfatin, TNF-α, IL-6 and PAI-1. The variation in FFA levels differed between the groups during the evening. Plasma ghrelin and glucagon levels did not display diurnal variations.CONCLUSIONS: Young men born SGA exhibit elevated 24-h blood glucose, and plasma glucagon and resistin levels with no major differences in diurnal rhythms of these or other key metabolic hormones, substrates or inflammatory markers implicated in the origin of adiposity and T2D.

KW - Blood Glucose

KW - C-Peptide

KW - Circadian Rhythm

KW - Diabetes Mellitus, Type 2

KW - Fatty Acids, Nonesterified

KW - Gestational Age

KW - Ghrelin

KW - Glucagon-Like Peptide 1

KW - Humans

KW - Infant, Newborn

KW - Infant, Small for Gestational Age

KW - Insulin

KW - Interleukin-6

KW - Leptin

KW - Male

KW - Resistin

KW - Triglycerides

KW - Tumor Necrosis Factor-alpha

KW - Young Adult

KW - Journal Article

U2 - 10.1530/EJE-16-0177

DO - 10.1530/EJE-16-0177

M3 - Journal article

C2 - 27252486

VL - 175

SP - 29

EP - 40

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 1

ER -

ID: 49914931