Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital

Efficacy and Safety of Lampalizumab for Geographic Atrophy Due to Age-Related Macular Degeneration: Chroma and Spectri Phase 3 Randomized Clinical Trials

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Association of Choroidal Effusion and Infusion of Daratumumab

    Publikation: Bidrag til tidsskriftLetter

  2. An Expanded Test Panel for Assessment of Fringe Benefits From Cataract Surgery

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  3. Clinicopathological Features of Ocular Adnexal Mantle-Cell Lymphoma in an International Multicenter Cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Age-Related Macular Degeneration in Patients With Chronic Myeloproliferative Neoplasms

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Retinal layer segmentation in rodent OCT images: Local intensity profiles & fully convolutional neural networks

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Progression Over 5 Years of Prelaminar Hyperreflective Lines to Optic Disc Drusen in the Copenhagen Child Cohort 2000 Eye Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Migration of an outer retinal element in a healthy child followed by longitudinal multimodal imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Michael Larsen (Medlem af forfattergruppering)
  • Chroma and Spectri Study Investigators
Vis graf over relationer

Importance: Geographic atrophy (GA) secondary to age-related macular degeneration is a leading cause of visual disability in older individuals. A phase 2 trial suggested that lampalizumab, a selective complement factor D inhibitor, reduced the rate of GA enlargement, warranting phase 3 trials.

Objective: To assess the safety and efficacy of lampalizumab vs sham procedure on enlargement of GA.

Design, Setting, and Participants: Two identically designed phase 3 double-masked, randomized, sham-controlled clinical trials, Chroma and Spectri, enrolled participants from August 28, 2014, to October 6, 2016, at 275 sites in 23 countries. Participants were aged 50 years or older, with bilateral GA and no prior or active choroidal neovascularization in either eye and GA lesions in the study eye measuring 2.54 to 17.78 mm2 with diffuse or banded fundus autofluorescence patterns.

Interventions: Participants were randomized 2:1:2:1 to receive 10 mg of intravitreous lampalizumab every 4 weeks, sham procedure every 4 weeks, 10 mg of lampalizumab every 6 weeks, or sham procedure every 6 weeks, through 96 weeks.

Main Outcomes and Measures: Safety and efficacy assessed as mean change from baseline in GA lesion area at week 48 from centrally read fundus autofluorescence images of the lampalizumab arms vs pooled sham arms, in the intent-to-treat population and by complement factor I-profile genetic biomarker.

Results: A total of 906 participants (553 women and 353 men; mean [SD] age, 78.1 [8.1] years) were enrolled in Chroma and 975 participants (578 women and 397 men; mean [SD] age, 77.9 [8.1] years) were enrolled in Spectri; 1733 of the 1881 participants (92.1%) completed the studies through 48 weeks. The adjusted mean increases in GA lesion area from baseline at week 48 were 1.93 to 2.09 mm2 across all groups in both studies. Differences in adjusted mean change in GA lesion area (lampalizumab minus sham) were -0.02 mm2 (95% CI, -0.21 to 0.16 mm2; P = .80) for lampalizumab every 4 weeks in Chroma, 0.16 mm2 (95% CI, 0.00-0.31 mm2; P = .048) for lampalizumab every 4 weeks in Spectri, 0.05 mm2 (95% CI, -0.13 to 0.24 mm2; P = .59) for lampalizumab every 6 weeks in Chroma, and 0.09 mm2 (95% CI, -0.07 to 0.24 mm2; P = .27) for lampalizumab every 6 weeks in Spectri. No benefit of lampalizumab was observed across prespecified subgroups, including by complement factor I-profile biomarker. Endophthalmitis occurred after 5 of 12 447 injections (0.04%) or in 5 of 1252 treated participants (0.4%) through week 48.

Conclusions and Relevance: In Chroma and Spectri, the largest studies of GA conducted to date, lampalizumab did not reduce GA enlargement vs sham during 48 weeks of treatment. Results highlight the substantial and consistent enlargement of GA, at a mean of approximately 2 mm2 per year.

Trial Registration: Identifier: NCT02247479 and NCT02247531.

TidsskriftJAMA Ophthalmology
Udgave nummer6
Sider (fra-til)666-677
Antal sider12
StatusUdgivet - 2018

ID: 56706075