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Effect of progressive resistance training on persistent pain after axillary dissection in breast cancer: a randomized controlled trial

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Ammitzbøll, Gunn ; Andersen, Kenneth Geving ; Bidstrup, Pernille Envold ; Johansen, Christoffer ; Lanng, Charlotte ; Kroman, Niels ; Zerahn, Bo ; Hyldegaard, Ole ; Andersen, Elisabeth Wreford ; Dalton, Susanne Oksbjerg. / Effect of progressive resistance training on persistent pain after axillary dissection in breast cancer : a randomized controlled trial. I: Breast Cancer Research and Treatment. 2020 ; Bind 179, Nr. 1. s. 173-183.

Bibtex

@article{b328d94884804bc1a64d09fa16a250ab,
title = "Effect of progressive resistance training on persistent pain after axillary dissection in breast cancer: a randomized controlled trial",
abstract = "PURPOSE: Persistent pain is a known challenge among breast cancer survivors. In secondary analyses of a randomized controlled trial, we examined the effect of progressive resistance training on persistent pain in the post-operative year in women treated for breast cancer with axillary lymph node dissection.METHODS: We randomized 158 women after BC surgery with Axillary Lymph Node Dissection (ALND) (1:1) to usual care or a 1-year, supervised and self-administered, progressive resistance training intervention initiated 3 weeks after surgery. A questionnaire at baseline, 20 weeks and 12 months assessed the intensity and frequency of pain, neuropathic pain and influence of pain on aspects of daily life. We analysed the effect using linear mixed models and multinomial logistic regression models for repeated measures.RESULTS: A high percentage of participants experienced baseline pain (85{\%} and 83{\%} in the control and intervention groups respectively) and by the 12 month assessment these numbers were more than halved. A high proportion of participants also experienced neuropathic pain (88{\%} and 89{\%} in control and intervention group respectively), a finding that was stable throughout the study period. The effect on intensity of pain indicators favoured the exercise group, although most estimates did not reach statistical significance, with differences being small.CONCLUSION: For women who had BC surgery with ALND, our progressive resistance training intervention conferred no benefit over usual care in reducing pain. Importantly, it did not increase the risk of pain both in the short and long term rehabilitative phase.",
keywords = "Axillary lymph node dissection, Breast cancer, Oncology, Pain, Resistance training, Lymph Node Excision/adverse effects, Humans, Middle Aged, Resistance Training, Pain, Postoperative/rehabilitation, Treatment Failure, Axilla, Adult, Female, Aged, Pain Measurement, Breast Neoplasms/therapy",
author = "Gunn Ammitzb{\o}ll and Andersen, {Kenneth Geving} and Bidstrup, {Pernille Envold} and Christoffer Johansen and Charlotte Lanng and Niels Kroman and Bo Zerahn and Ole Hyldegaard and Andersen, {Elisabeth Wreford} and Dalton, {Susanne Oksbjerg}",
year = "2020",
month = "1",
doi = "10.1007/s10549-019-05461-z",
language = "English",
volume = "179",
pages = "173--183",
journal = "Breast Cancer Research and Treatment",
issn = "0167-6806",
publisher = "Springer New York LLC",
number = "1",

}

RIS

TY - JOUR

T1 - Effect of progressive resistance training on persistent pain after axillary dissection in breast cancer

T2 - a randomized controlled trial

AU - Ammitzbøll, Gunn

AU - Andersen, Kenneth Geving

AU - Bidstrup, Pernille Envold

AU - Johansen, Christoffer

AU - Lanng, Charlotte

AU - Kroman, Niels

AU - Zerahn, Bo

AU - Hyldegaard, Ole

AU - Andersen, Elisabeth Wreford

AU - Dalton, Susanne Oksbjerg

PY - 2020/1

Y1 - 2020/1

N2 - PURPOSE: Persistent pain is a known challenge among breast cancer survivors. In secondary analyses of a randomized controlled trial, we examined the effect of progressive resistance training on persistent pain in the post-operative year in women treated for breast cancer with axillary lymph node dissection.METHODS: We randomized 158 women after BC surgery with Axillary Lymph Node Dissection (ALND) (1:1) to usual care or a 1-year, supervised and self-administered, progressive resistance training intervention initiated 3 weeks after surgery. A questionnaire at baseline, 20 weeks and 12 months assessed the intensity and frequency of pain, neuropathic pain and influence of pain on aspects of daily life. We analysed the effect using linear mixed models and multinomial logistic regression models for repeated measures.RESULTS: A high percentage of participants experienced baseline pain (85% and 83% in the control and intervention groups respectively) and by the 12 month assessment these numbers were more than halved. A high proportion of participants also experienced neuropathic pain (88% and 89% in control and intervention group respectively), a finding that was stable throughout the study period. The effect on intensity of pain indicators favoured the exercise group, although most estimates did not reach statistical significance, with differences being small.CONCLUSION: For women who had BC surgery with ALND, our progressive resistance training intervention conferred no benefit over usual care in reducing pain. Importantly, it did not increase the risk of pain both in the short and long term rehabilitative phase.

AB - PURPOSE: Persistent pain is a known challenge among breast cancer survivors. In secondary analyses of a randomized controlled trial, we examined the effect of progressive resistance training on persistent pain in the post-operative year in women treated for breast cancer with axillary lymph node dissection.METHODS: We randomized 158 women after BC surgery with Axillary Lymph Node Dissection (ALND) (1:1) to usual care or a 1-year, supervised and self-administered, progressive resistance training intervention initiated 3 weeks after surgery. A questionnaire at baseline, 20 weeks and 12 months assessed the intensity and frequency of pain, neuropathic pain and influence of pain on aspects of daily life. We analysed the effect using linear mixed models and multinomial logistic regression models for repeated measures.RESULTS: A high percentage of participants experienced baseline pain (85% and 83% in the control and intervention groups respectively) and by the 12 month assessment these numbers were more than halved. A high proportion of participants also experienced neuropathic pain (88% and 89% in control and intervention group respectively), a finding that was stable throughout the study period. The effect on intensity of pain indicators favoured the exercise group, although most estimates did not reach statistical significance, with differences being small.CONCLUSION: For women who had BC surgery with ALND, our progressive resistance training intervention conferred no benefit over usual care in reducing pain. Importantly, it did not increase the risk of pain both in the short and long term rehabilitative phase.

KW - Axillary lymph node dissection

KW - Breast cancer

KW - Oncology

KW - Pain

KW - Resistance training

KW - Lymph Node Excision/adverse effects

KW - Humans

KW - Middle Aged

KW - Resistance Training

KW - Pain, Postoperative/rehabilitation

KW - Treatment Failure

KW - Axilla

KW - Adult

KW - Female

KW - Aged

KW - Pain Measurement

KW - Breast Neoplasms/therapy

U2 - 10.1007/s10549-019-05461-z

DO - 10.1007/s10549-019-05461-z

M3 - Journal article

VL - 179

SP - 173

EP - 183

JO - Breast Cancer Research and Treatment

JF - Breast Cancer Research and Treatment

SN - 0167-6806

IS - 1

ER -

ID: 58123396