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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Effect of Dapagliflozin in DAPA-HF According to Background Glucose-Lowering Therapy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • DAPA-HF Investigators and Committees
  • Gunnar Hilmar Gislason (Medlem af forfattergruppering)
  • Morten Schou (Medlem af forfattergruppering)
Vis graf over relationer

OBJECTIVE: To determine whether the benefits of dapagliflozin in patients with heart failure and reduced ejection fraction (HFrEF) and type 2 diabetes in the Dapagliflozin And Prevention of Adverse-Outcomes in Heart Failure trial (DAPA-HF) varied by background glucose-lowering therapy (GLT).

RESEARCH DESIGN AND METHODS: We examined the effect of study treatment by the use or not of GLT and by GLT classes and combinations. The primary outcome was a composite of worsening heart failure (hospitalization or urgent visit requiring intravenous therapy) or cardiovascular death.

RESULTS: In the 2,139 type 2 diabetes patients, the effect of dapagliflozin on the primary outcome was consistent by GLT use or no use (hazard ratio 0.72 [95% CI 0.58-0.88] vs. 0.86 [0.60-1.23]; interaction P = 0.39) and across GLT classes.

CONCLUSIONS: In DAPA-HF, dapagliflozin improved outcomes irrespective of use or no use of GLT or by GLT type used in patients with type 2 diabetes and HFrEF.

OriginalsprogEngelsk
TidsskriftDiabetes Care
Vol/bind43
Udgave nummer11
Sider (fra-til)2878-2881
Antal sider4
ISSN1935-5548
DOI
StatusUdgivet - nov. 2020

Bibliografisk note

© 2020 by the American Diabetes Association.

ID: 61265145