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Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke

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Harvard

Zangari, R, Zanier, ER, Torgano, G, Bersano, A, Beretta, S, Beghi, E, Casolla, B, Checcarelli, N, Lanfranconi, S, Maino, A, Mandelli, C, Micieli, G, Orzi, F, Picetti, E, Silvestrini, M, Stocchetti, N, Zecca, B, Garred, P, De Simoni, MG & LEPAS group 2016, 'Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke' Journal of Neuroinflammation, bind 13, s. 16. https://doi.org/10.1186/s12974-016-0481-2

APA

Zangari, R., Zanier, E. R., Torgano, G., Bersano, A., Beretta, S., Beghi, E., ... LEPAS group (2016). Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke. Journal of Neuroinflammation, 13, 16. https://doi.org/10.1186/s12974-016-0481-2

CBE

Zangari R, Zanier ER, Torgano G, Bersano A, Beretta S, Beghi E, Casolla B, Checcarelli N, Lanfranconi S, Maino A, Mandelli C, Micieli G, Orzi F, Picetti E, Silvestrini M, Stocchetti N, Zecca B, Garred P, De Simoni MG, LEPAS group. 2016. Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke. Journal of Neuroinflammation. 13:16. https://doi.org/10.1186/s12974-016-0481-2

MLA

Vancouver

Author

Zangari, R ; Zanier, E R ; Torgano, G ; Bersano, A ; Beretta, S ; Beghi, E ; Casolla, B ; Checcarelli, N ; Lanfranconi, S ; Maino, A ; Mandelli, C ; Micieli, G ; Orzi, F ; Picetti, E ; Silvestrini, M ; Stocchetti, N ; Zecca, B ; Garred, P ; De Simoni, M G ; LEPAS group. / Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke. I: Journal of Neuroinflammation. 2016 ; Bind 13. s. 16.

Bibtex

@article{1805baac70914d6f95a8492dafbb70f0,
title = "Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke",
abstract = "BACKGROUND: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke.METHODS: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS).RESULTS: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p < 0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p < 0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p < 0.001 and <0.05, respectively). For MBL no difference was detected between patients and controls or within patients at the different time points. In multivariate analysis, early ficolin-1 was independently associated with unfavorable mRS outcome (adjusted odds ratio (OR): 2.21, confidence interval (CI) 95 {\%} 1.11-4.39, p = 0.023). Early ficolin-1 improved the discriminating ability of an outcome model including NIHSS and age (area under the curve (AUC) 0.95, CI 95 {\%} 0.90-0.99, p = 0.0001).CONCLUSIONS: The ficolins are consumed within 6 h after stroke implicating activation of the LP. Early ficolin-1 is selectively related to 3-month unfavorable outcome.",
keywords = "Journal Article, Research Support, Non-U.S. Gov't",
author = "R Zangari and Zanier, {E R} and G Torgano and A Bersano and S Beretta and E Beghi and B Casolla and N Checcarelli and S Lanfranconi and A Maino and C Mandelli and G Micieli and F Orzi and E Picetti and M Silvestrini and N Stocchetti and B Zecca and P Garred and {De Simoni}, {M G} and {LEPAS group}",
year = "2016",
doi = "10.1186/s12974-016-0481-2",
language = "English",
volume = "13",
pages = "16",
journal = "Journal of Neuroinflammation",
issn = "1742-2094",
publisher = "BioMed Central Ltd",

}

RIS

TY - JOUR

T1 - Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke

AU - Zangari, R

AU - Zanier, E R

AU - Torgano, G

AU - Bersano, A

AU - Beretta, S

AU - Beghi, E

AU - Casolla, B

AU - Checcarelli, N

AU - Lanfranconi, S

AU - Maino, A

AU - Mandelli, C

AU - Micieli, G

AU - Orzi, F

AU - Picetti, E

AU - Silvestrini, M

AU - Stocchetti, N

AU - Zecca, B

AU - Garred, P

AU - De Simoni, M G

AU - LEPAS group

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke.METHODS: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS).RESULTS: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p < 0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p < 0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p < 0.001 and <0.05, respectively). For MBL no difference was detected between patients and controls or within patients at the different time points. In multivariate analysis, early ficolin-1 was independently associated with unfavorable mRS outcome (adjusted odds ratio (OR): 2.21, confidence interval (CI) 95 % 1.11-4.39, p = 0.023). Early ficolin-1 improved the discriminating ability of an outcome model including NIHSS and age (area under the curve (AUC) 0.95, CI 95 % 0.90-0.99, p = 0.0001).CONCLUSIONS: The ficolins are consumed within 6 h after stroke implicating activation of the LP. Early ficolin-1 is selectively related to 3-month unfavorable outcome.

AB - BACKGROUND: Several lines of evidence support the involvement of the lectin pathway of complement (LP) in the pathogenesis of acute ischemic stroke. The aim of this multicenter observational study was to assess the prognostic value of different circulating LP initiators in acute stroke.METHODS: Plasma levels of the LP initiators ficolin-1, -2, and -3 and mannose-binding lectin (MBL) were measured in 80 stroke patients at 6 h only and in 85 patients at 48 h and later. Sixty-one age- and sex-matched healthy individuals served as controls. Stroke severity was measured on admission using the National Institutes of Health Stroke Scale (NIHSS). The outcome was measured at 90 days by the modified Rankin Scale (mRS).RESULTS: Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 μg/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher (0.45 μg/ml, p < 0.0001) compared to the 6 h samples and to controls. Likewise, ficolin-2 was decreased at 6 h (2.70 vs 4.40 μg/ml, p < 0.0001) but not at 48 h. Ficolin-3 was decreased both at 6 and 48 h (17.3 and 18.23 vs 21.5 μg/ml, p < 0.001 and <0.05, respectively). For MBL no difference was detected between patients and controls or within patients at the different time points. In multivariate analysis, early ficolin-1 was independently associated with unfavorable mRS outcome (adjusted odds ratio (OR): 2.21, confidence interval (CI) 95 % 1.11-4.39, p = 0.023). Early ficolin-1 improved the discriminating ability of an outcome model including NIHSS and age (area under the curve (AUC) 0.95, CI 95 % 0.90-0.99, p = 0.0001).CONCLUSIONS: The ficolins are consumed within 6 h after stroke implicating activation of the LP. Early ficolin-1 is selectively related to 3-month unfavorable outcome.

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1186/s12974-016-0481-2

DO - 10.1186/s12974-016-0481-2

M3 - Journal article

VL - 13

SP - 16

JO - Journal of Neuroinflammation

JF - Journal of Neuroinflammation

SN - 1742-2094

ER -

ID: 48989760