Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Early Coronary Atherosclerosis in Women With Previous Preeclampsia

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Reintervention and Survival After Transcatheter Pulmonary Valve Replacement

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association of Variants Near the Bradykinin Receptor B2 Gene With Angioedema in Patients Taking ACE Inhibitors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Multicenter Study of Endocarditis After Transcatheter Pulmonary Valve Replacement

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Long-term effects of cardiac rehabilitation after heart valve surgery - results from the randomised CopenHeartVR trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Three decades of heart transplantation: experience and long-term outcome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Coronary artery- and aortic valve calcifications in patients with Philadelphia-negative myeloproliferative neoplasms

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Systolic Blood Pressure and Effects of Screening for Atrial Fibrillation With Long-Term Continuous Monitoring (a LOOP Substudy)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background: Women with previous preeclampsia have an increased risk of coronary artery disease later in life. Objectives: This study aimed to determine the prevalence of coronary atherosclerosis in younger women with previous preeclampsia in comparison with women from the general population. Methods: Women aged 40-55 years with previous preeclampsia were matched 1:1 on age and parity with women from the general population. Participants completed an extensive questionnaire, a clinical examination, and a coronary computed tomography angiography (CTA). The main study outcome was the prevalence of any coronary atherosclerosis on coronary CTA or a calcium score >0 in case of a nondiagnostic coronary CTA. Results: A total of 1,417 women, with a mean age of 47 years, were included (708 women with previous preeclampsia and 709 control subjects from the general population). Women with previous preeclampsia were more likely to have hypertension (284 [40.1%] vs 162 [22.8%]; P < 0.001), dyslipidemia (338 [47.7%] vs 296 [41.7%]; P = 0.023), diabetes mellitus (24 [3.4%] vs 8 [1.1%]; P = 0.004), and high body mass index (27.3 ± 5.7 kg/m 2 vs 25.0 ± 4.2 kg/m 2; P < 0.001). Cardiac computed tomography was performed in all women. The prevalence of any coronary atherosclerosis was higher in the preeclampsia group (193 [27.4%] vs 141 [20.0%]; P = 0.001) with an OR: 1.41 (95% CI: 1.08-1.85; P = 0.012) after adjustment for age, dyslipidemia, diabetes mellitus, smoking, body mass index, menopause, and parity. Conclusions: Younger women with previous preeclampsia had a slightly higher prevalence of coronary atherosclerosis compared with age- and parity-matched women from the general population. Preeclampsia remained an independent risk factor after adjustment for traditional cardiovascular risk factors. (The CoPenHagen PREeClampsia and cardIOvascUlar diSease study [CPH-PRECIOUS]; NCT03949829)

OriginalsprogEngelsk
TidsskriftJournal of the American College of Cardiology
Vol/bind79
Udgave nummer23
Sider (fra-til)2310-2321
Antal sider12
ISSN0735-1097
DOI
StatusUdgivet - 14 jun. 2022

Bibliografisk note

Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

ID: 78821284