Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
Initiation of statin treatment is suggested to increase the international normalised ratio (INR) among warfarin users. However, available data is limited and conflicting. We conducted a register-based cohort study to evaluate the drug-drug interaction between warfarin and statins. By linking data on INR measurements and filled prescriptions, we identified warfarin users 2000-2015 initiating simvastatin (n=1,363), atorvastatin (n=165), or rosuvastatin (n=23). Simvastatin initiation led to an increase in mean INR from 2.40 to 2.71, with INRs peaking after 4 weeks, corresponding to a mean change of 0.32 (95%CI 0.25-0.38). High-dose and low-dose simvastatin led to comparable changes (mean change 0.33 vs 0.29). Initiation of atorvastatin and rosuvastatin lead to INR increases of 0.27 (95%CI 0.12-0.42) and 0.30 (95%CI -0.09-0.69). In conclusion, initiation of simvastatin, atorvastatin, or rosuvastatin among warfarin users led to a minor increase in INR. The magnitude of this change is for most patients likely of limited clinical relevance.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Clinical Pharmacology |
Vol/bind | 87 |
Udgave nummer | 2 |
Sider (fra-til) | 694-699 |
Antal sider | 6 |
ISSN | 0306-5251 |
DOI | |
Status | Udgivet - feb. 2021 |
ID: 60052930