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Rigshospitalet - en del af Københavns Universitetshospital
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Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry

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  • Torbjörn Tomson
  • Dina Battino
  • Erminio Bonizzoni
  • John Craig
  • Dick Lindhout
  • Anne Sabers
  • Emilio Perucca
  • Frank Vajda
  • EURAP study group
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Prenatal exposure to antiepileptic drugs is associated with a greater risk of major congenital malformations, but there is inadequate information on the comparative teratogenicity of individual antiepileptic drugs and the association with dose. We aimed to establish the risks of major congenital malformations after monotherapy exposure to four major antiepileptic drugs at different doses.
OriginalsprogEngelsk
TidsskriftLancet neurology
Vol/bind10
Udgave nummer7
Sider (fra-til)609-17
Antal sider9
ISSN1474-4422
DOI
StatusUdgivet - 2011

ID: 33245446