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Does height and IGF-I determine pubertal timing in girls?

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@article{7ceff3aa91ef4e2eb03652173ee54e73,
title = "Does height and IGF-I determine pubertal timing in girls?",
abstract = "BACKGROUND: Pubertal timing is closely linked to growth regulated by the growth hormone/insulin-like factor (GH/IGF) axis that includes IGF-regulating factors such as pregnancy-associated plasma protein-A/A2 (PAPP-A/PAPP-A2) and stanniocalcin 2 (STC2). We investigated the association between height, IGF-I concentration, and PAPPA, PAPPA2, and STC2 genotypes on the timing of female pubertal milestones.METHODS: Height, IGF-I, and genotypes were analyzed in 1382 Danish girls from the general population, 67 patients with tall stature (height ≥2 SD), and 124 patients with short stature (height ≤-2 SD). The main outcomes were breast stage and menarche.RESULTS: Thelarche occurred significantly earlier in patients with tall stature (mean age 9.37 years [95% confidence interval (CI) 8.87-9.87]) and later in patients with short stature (11.07 years [95% CI 10.7-11.43]) compared with girls within the normal range (9.96 years [95% CI 9.85-10.07]) (p = 0.02 and p < 0.01, respectively). Girls with higher IGF-I levels experienced thelarche and menarche earlier compared with the rest of the cohort (p < 0.01). Genotypes were not associated with age at thelarche nor menarche, but the PAPPA2 minor allele carriers were shorter compared with major allele carriers, p = 0.03.CONCLUSIONS: Height and IGF-I, but not PAPP-A, PAPP-A2, and STC2 genotypes, were negatively associated with age at thelarche and menarche.IMPACT: Girls with tall and short stature enter puberty earlier and later compared with girls with normal height.Girls with higher insulin-growth factor-I in childhood enter puberty earlier.Pubertal timing is influenced by longitudinal growth and IGF-I levels earlier in childhood.Childhood growth and the levels of IGF-I in childhood may be biomarkers of pubertal timing.",
author = "Upners, {Emmie N} and Busch, {Alexander S} and Kristian Almstrup and Petersen, {J{\o}rgen H} and Maria Assens and Main, {Katharina M} and Jensen, {Rikke B} and Anders Juul",
year = "2020",
month = nov,
day = "3",
doi = "10.1038/s41390-020-01215-6",
language = "English",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Does height and IGF-I determine pubertal timing in girls?

AU - Upners, Emmie N

AU - Busch, Alexander S

AU - Almstrup, Kristian

AU - Petersen, Jørgen H

AU - Assens, Maria

AU - Main, Katharina M

AU - Jensen, Rikke B

AU - Juul, Anders

PY - 2020/11/3

Y1 - 2020/11/3

N2 - BACKGROUND: Pubertal timing is closely linked to growth regulated by the growth hormone/insulin-like factor (GH/IGF) axis that includes IGF-regulating factors such as pregnancy-associated plasma protein-A/A2 (PAPP-A/PAPP-A2) and stanniocalcin 2 (STC2). We investigated the association between height, IGF-I concentration, and PAPPA, PAPPA2, and STC2 genotypes on the timing of female pubertal milestones.METHODS: Height, IGF-I, and genotypes were analyzed in 1382 Danish girls from the general population, 67 patients with tall stature (height ≥2 SD), and 124 patients with short stature (height ≤-2 SD). The main outcomes were breast stage and menarche.RESULTS: Thelarche occurred significantly earlier in patients with tall stature (mean age 9.37 years [95% confidence interval (CI) 8.87-9.87]) and later in patients with short stature (11.07 years [95% CI 10.7-11.43]) compared with girls within the normal range (9.96 years [95% CI 9.85-10.07]) (p = 0.02 and p < 0.01, respectively). Girls with higher IGF-I levels experienced thelarche and menarche earlier compared with the rest of the cohort (p < 0.01). Genotypes were not associated with age at thelarche nor menarche, but the PAPPA2 minor allele carriers were shorter compared with major allele carriers, p = 0.03.CONCLUSIONS: Height and IGF-I, but not PAPP-A, PAPP-A2, and STC2 genotypes, were negatively associated with age at thelarche and menarche.IMPACT: Girls with tall and short stature enter puberty earlier and later compared with girls with normal height.Girls with higher insulin-growth factor-I in childhood enter puberty earlier.Pubertal timing is influenced by longitudinal growth and IGF-I levels earlier in childhood.Childhood growth and the levels of IGF-I in childhood may be biomarkers of pubertal timing.

AB - BACKGROUND: Pubertal timing is closely linked to growth regulated by the growth hormone/insulin-like factor (GH/IGF) axis that includes IGF-regulating factors such as pregnancy-associated plasma protein-A/A2 (PAPP-A/PAPP-A2) and stanniocalcin 2 (STC2). We investigated the association between height, IGF-I concentration, and PAPPA, PAPPA2, and STC2 genotypes on the timing of female pubertal milestones.METHODS: Height, IGF-I, and genotypes were analyzed in 1382 Danish girls from the general population, 67 patients with tall stature (height ≥2 SD), and 124 patients with short stature (height ≤-2 SD). The main outcomes were breast stage and menarche.RESULTS: Thelarche occurred significantly earlier in patients with tall stature (mean age 9.37 years [95% confidence interval (CI) 8.87-9.87]) and later in patients with short stature (11.07 years [95% CI 10.7-11.43]) compared with girls within the normal range (9.96 years [95% CI 9.85-10.07]) (p = 0.02 and p < 0.01, respectively). Girls with higher IGF-I levels experienced thelarche and menarche earlier compared with the rest of the cohort (p < 0.01). Genotypes were not associated with age at thelarche nor menarche, but the PAPPA2 minor allele carriers were shorter compared with major allele carriers, p = 0.03.CONCLUSIONS: Height and IGF-I, but not PAPP-A, PAPP-A2, and STC2 genotypes, were negatively associated with age at thelarche and menarche.IMPACT: Girls with tall and short stature enter puberty earlier and later compared with girls with normal height.Girls with higher insulin-growth factor-I in childhood enter puberty earlier.Pubertal timing is influenced by longitudinal growth and IGF-I levels earlier in childhood.Childhood growth and the levels of IGF-I in childhood may be biomarkers of pubertal timing.

U2 - 10.1038/s41390-020-01215-6

DO - 10.1038/s41390-020-01215-6

M3 - Journal article

C2 - 33142306

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

ER -

ID: 61413408