Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Distribution of microcrack surface density in the human otic capsule

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Manuscript title: the maxillary swing approach - the first Scandinavian experience

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Autologous fibrin sealant co-delivered with antibiotics is a robust method for topical antibiotic treatment after sinus surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Nordic results of cochlear implantation in adults: speech perception and patient reported outcomes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Microcrack surface density in the human otic capsule: An unbiased stereological quantification

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Effect of Simulator-Integrated Tutoring for Guidance in Virtual Reality Simulation Training

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Stereologic Investigation of Mastoid Air Cell Geometry: Volume, Surface Area, and Anisotropy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The bony otic capsule is comprised of highly mineralized and dense compact bone. It is rarely remodelled and degenerative changes, therefore, accumulate around the inner ear. It is also a predilection site for the pathological remodelling seen in otosclerosis. Morphometric studies have documented increased numbers of dead osteocytes and microcracks in the human otic capsule. Microcracks may disrupt the lacuno-canalicular network and cause osteocyte apoptosis ultimately breaking up the perilabyrinthine bone signalling pathways and dynamics. This may be important to understand the pathogenesis of remodelling diseases like otosclerosis.

AIMS/OBJECTIVES: This study describes the spatial and regional distribution of microcrack surface density in relation to the inner ear and compares it to that previously recorded for otosclerosis.

MATERIAL AND METHODS: Forty-two temporal bones and five ribs were used. All samples were undecalcified, bulk stained in basic fuchsin and plastic embedded. Unbiased stereology was used to estimate the true surface density of microcracks (mm2/mm3) in perilabyrinthine bone.

RESULTS: The surface density of microcracks accumulates around the inner ear spaces, particularly in the lateral window regions, and increases with age.

CONCLUSIONS AND SIGNIFICANCE: This study documents the spatial and temporal association between microfractures and otosclerosis in the otic capsule.

OriginalsprogEngelsk
TidsskriftActa Oto-Laryngologica
Vol/bind141
Udgave nummer6
Sider (fra-til)567-571
Antal sider5
ISSN0001-6489
DOI
StatusUdgivet - jun. 2021

ID: 65607028