Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Kjems, J, Zukauskaite, R, Johansen, J, Eriksen, JG, Lassen, P, Andersen, E, Andersen, M, Farhadi, M, Overgaard, J, Vogelius, IR & Friborg, J 2021, 'Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study', Acta Oncologica, bind 60, nr. 11, s. 1472-1480. https://doi.org/10.1080/0284186X.2021.1959056

APA

Kjems, J., Zukauskaite, R., Johansen, J., Eriksen, J. G., Lassen, P., Andersen, E., Andersen, M., Farhadi, M., Overgaard, J., Vogelius, I. R., & Friborg, J. (2021). Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study. Acta Oncologica, 60(11), 1472-1480. https://doi.org/10.1080/0284186X.2021.1959056

CBE

MLA

Vancouver

Author

Kjems, Julie ; Zukauskaite, Ruta ; Johansen, Jørgen ; Eriksen, Jesper Grau ; Lassen, Pernille ; Andersen, Elo ; Andersen, Maria ; Farhadi, Mohammad ; Overgaard, Jens ; Vogelius, Ivan R ; Friborg, Jeppe. / Distant metastases in squamous cell carcinoma of the pharynx and larynx : a population-based DAHANCA study. I: Acta Oncologica. 2021 ; Bind 60, Nr. 11. s. 1472-1480.

Bibtex

@article{7d5549aa143e4978b1eb317413acc4b0,
title = "Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study",
abstract = "BACKGROUND: In head and neck cancer, distant metastases may be present at diagnosis (M1) or occur after treatment (DM). It is unknown whether M1 and DM follow the same clinical development and share prognosis, as population-based studies regarding outcomes are scarce. Therefore, we investigated the incidence, location of metastases and overall survival of patients with M1 and DM.MATERIALS AND METHODS: Patients diagnosed with squamous cell carcinoma of the pharynx and larynx in Denmark 2008-2017 were identified in the Danish Head and Neck Cancer Group (DAHANCA) database. We identified 7300 patients, of whom 197 (3%) had M1 and 498 (8%) developed DM during follow-up.RESULTS: The 5-year cumulative incidence of DM was 8%. 1- and 2-year overall survival for DM (27% and 13%) vs. M1 (28% and 9%) were equally poor. There was no significant difference in location of metastases for M1 and DM and the most frequently involved organs were lungs, bone, lymph nodes and liver, in descending order. In oropharyngeal squamous cell carcinomas, the location of metastases did not differ by p16-status. For p16-positive patients, 21% of DM occurred later than three years of follow-up compared to 7% of p16-negative patients.CONCLUSION: Incidence, location of metastases and prognosis of primary metastatic (M1) or post-treatment metastatic (DM) disease in pharyngeal and laryngeal squamous cell carcinoma are similar in this register-based study.",
keywords = "Distant metastases, head and neck cancer, human papillomavirus, radiotherapy, the pattern of failure",
author = "Julie Kjems and Ruta Zukauskaite and J{\o}rgen Johansen and Eriksen, {Jesper Grau} and Pernille Lassen and Elo Andersen and Maria Andersen and Mohammad Farhadi and Jens Overgaard and Vogelius, {Ivan R} and Jeppe Friborg",
year = "2021",
month = nov,
doi = "10.1080/0284186X.2021.1959056",
language = "English",
volume = "60",
pages = "1472--1480",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Informa Healthcare",
number = "11",

}

RIS

TY - JOUR

T1 - Distant metastases in squamous cell carcinoma of the pharynx and larynx

T2 - a population-based DAHANCA study

AU - Kjems, Julie

AU - Zukauskaite, Ruta

AU - Johansen, Jørgen

AU - Eriksen, Jesper Grau

AU - Lassen, Pernille

AU - Andersen, Elo

AU - Andersen, Maria

AU - Farhadi, Mohammad

AU - Overgaard, Jens

AU - Vogelius, Ivan R

AU - Friborg, Jeppe

PY - 2021/11

Y1 - 2021/11

N2 - BACKGROUND: In head and neck cancer, distant metastases may be present at diagnosis (M1) or occur after treatment (DM). It is unknown whether M1 and DM follow the same clinical development and share prognosis, as population-based studies regarding outcomes are scarce. Therefore, we investigated the incidence, location of metastases and overall survival of patients with M1 and DM.MATERIALS AND METHODS: Patients diagnosed with squamous cell carcinoma of the pharynx and larynx in Denmark 2008-2017 were identified in the Danish Head and Neck Cancer Group (DAHANCA) database. We identified 7300 patients, of whom 197 (3%) had M1 and 498 (8%) developed DM during follow-up.RESULTS: The 5-year cumulative incidence of DM was 8%. 1- and 2-year overall survival for DM (27% and 13%) vs. M1 (28% and 9%) were equally poor. There was no significant difference in location of metastases for M1 and DM and the most frequently involved organs were lungs, bone, lymph nodes and liver, in descending order. In oropharyngeal squamous cell carcinomas, the location of metastases did not differ by p16-status. For p16-positive patients, 21% of DM occurred later than three years of follow-up compared to 7% of p16-negative patients.CONCLUSION: Incidence, location of metastases and prognosis of primary metastatic (M1) or post-treatment metastatic (DM) disease in pharyngeal and laryngeal squamous cell carcinoma are similar in this register-based study.

AB - BACKGROUND: In head and neck cancer, distant metastases may be present at diagnosis (M1) or occur after treatment (DM). It is unknown whether M1 and DM follow the same clinical development and share prognosis, as population-based studies regarding outcomes are scarce. Therefore, we investigated the incidence, location of metastases and overall survival of patients with M1 and DM.MATERIALS AND METHODS: Patients diagnosed with squamous cell carcinoma of the pharynx and larynx in Denmark 2008-2017 were identified in the Danish Head and Neck Cancer Group (DAHANCA) database. We identified 7300 patients, of whom 197 (3%) had M1 and 498 (8%) developed DM during follow-up.RESULTS: The 5-year cumulative incidence of DM was 8%. 1- and 2-year overall survival for DM (27% and 13%) vs. M1 (28% and 9%) were equally poor. There was no significant difference in location of metastases for M1 and DM and the most frequently involved organs were lungs, bone, lymph nodes and liver, in descending order. In oropharyngeal squamous cell carcinomas, the location of metastases did not differ by p16-status. For p16-positive patients, 21% of DM occurred later than three years of follow-up compared to 7% of p16-negative patients.CONCLUSION: Incidence, location of metastases and prognosis of primary metastatic (M1) or post-treatment metastatic (DM) disease in pharyngeal and laryngeal squamous cell carcinoma are similar in this register-based study.

KW - Distant metastases

KW - head and neck cancer

KW - human papillomavirus

KW - radiotherapy

KW - the pattern of failure

UR - http://www.scopus.com/inward/record.url?scp=85112080620&partnerID=8YFLogxK

U2 - 10.1080/0284186X.2021.1959056

DO - 10.1080/0284186X.2021.1959056

M3 - Journal article

C2 - 34369265

VL - 60

SP - 1472

EP - 1480

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 11

ER -

ID: 67942057