Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Differential effects of bile acids on the postprandial secretion of gut hormones: a randomized crossover study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Evidence for glucagon secretion and function within the human gut

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Role of the Transsulfuration Pathway in Non-Alcoholic Fatty Liver Disease

    Publikation: Bidrag til tidsskriftReviewpeer review

  3. Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Emma Rose McGlone
  • Khalefah Malallah
  • Joyceline Cuenco
  • Nicolai J Wewer Albrechtsen
  • Jens J Holst
  • Royce P Vincent
  • Charlotte Ling
  • Omar A Khan
  • Surabhi Verma
  • Ahmed R Ahmed
  • Julian R F Walters
  • Bernard Khoo
  • Stephen R Bloom
  • Tricia M M Tan
Vis graf over relationer

Bile acids (BA) regulate postprandial metabolism directly and indirectly by affecting the secretion of gut hormones like glucagon-like peptide-1 (GLP-1). The postprandial effects of BA on the secretion of other metabolically active hormones are not well understood. The objective of this study was to investigate the effects of oral ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) on postprandial secretion of GLP-1, oxyntomodulin (OXM), peptide YY (PYY), glucose-dependent insulinotropic peptide (GIP), glucagon, and ghrelin. Twelve healthy volunteers underwent a mixed meal test 60 min after ingestion of UDCA (12-16 mg/kg), CDCA (13-16 mg/kg), or no BA in a randomized crossover study. Glucose, insulin, GLP-1, OXM, PYY, GIP, glucagon, ghrelin, and fibroblast growth factor 19 were measured prior to BA administration at -60 and 0 min (just prior to mixed meal) and 15, 30, 60, 120, 180, and 240 min after the meal. UDCA and CDCA provoked differential gut hormone responses; UDCA did not have any significant effects, but CDCA provoked significant increases in GLP-1 and OXM and a profound reduction in GIP. CDCA increased fasting GLP-1 and OXM secretion in parallel with an increase in insulin. On the other hand, CDCA reduced postprandial secretion of GIP, with an associated reduction in postprandial insulin secretion. Exogenous CDCA can exert multiple salutary effects on the secretion of gut hormones; if these effects are confirmed in obesity and type 2 diabetes, CDCA may be a potential therapy for these conditions.NEW & NOTEWORTHY Oral CDCA and UDCA have different effects on gut and pancreatic hormone secretion. A single dose of CDCA increased fasting secretion of the hormones GLP-1 and OXM with an accompanying increase in insulin secretion. CDCA also reduced postprandial GIP secretion, which was associated with reduced insulin. In contrast, UDCA did not change gut hormone secretion fasting or postprandially. Oral CDCA could be beneficial to patients with obesity and diabetes.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Physiology: Endocrinology and Metabolism
Vol/bind320
Udgave nummer4
Sider (fra-til)E671-E679
ISSN0193-1849
DOI
StatusUdgivet - 1 apr. 2021

ID: 64874004