Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

Mikolić, A, van Klaveren, D, Oude Groeniger, J, Wiegers, EJA, Lingsma, HF, Zeldovich, M, von Steinbüchel, N, Maas, AIR, Roeters van Lennep, JE, Polinder, S, CENTER-TBI Participants and Investigators, Kondziella, D & Fabricius, ME 2021, 'Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury', Journal of Neurotrauma, bind 38, nr. 2, s. 235-251. https://doi.org/10.1089/neu.2020.7228

APA

Mikolić, A., van Klaveren, D., Oude Groeniger, J., Wiegers, E. J. A., Lingsma, H. F., Zeldovich, M., von Steinbüchel, N., Maas, A. I. R., Roeters van Lennep, J. E., Polinder, S., CENTER-TBI Participants and Investigators, Kondziella, D., & Fabricius, M. E. (2021). Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury. Journal of Neurotrauma, 38(2), 235-251. https://doi.org/10.1089/neu.2020.7228

CBE

Mikolić A, van Klaveren D, Oude Groeniger J, Wiegers EJA, Lingsma HF, Zeldovich M, von Steinbüchel N, Maas AIR, Roeters van Lennep JE, Polinder S, CENTER-TBI Participants and Investigators, Kondziella D, Fabricius ME. 2021. Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury. Journal of Neurotrauma. 38(2):235-251. https://doi.org/10.1089/neu.2020.7228

MLA

Vancouver

Mikolić A, van Klaveren D, Oude Groeniger J, Wiegers EJA, Lingsma HF, Zeldovich M o.a. Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury. Journal of Neurotrauma. 2021 jan 15;38(2):235-251. https://doi.org/10.1089/neu.2020.7228

Author

Mikolić, Ana ; van Klaveren, David ; Oude Groeniger, Joost ; Wiegers, Eveline J A ; Lingsma, Hester F ; Zeldovich, Marina ; von Steinbüchel, Nicole ; Maas, Andrew I R ; Roeters van Lennep, Jeanine E ; Polinder, Suzanne ; CENTER-TBI Participants and Investigators ; Kondziella, Daniel ; Fabricius, Martin Ejler. / Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury. I: Journal of Neurotrauma. 2021 ; Bind 38, Nr. 2. s. 235-251.

Bibtex

@article{64e5f93e7290476eb410cbc43044c121,
title = "Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury",
abstract = "Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care pathways, treatment characteristics, and outcomes following mild and moderate/severe TBI. We performed mixed-effects regression analyses in the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, stratified for injury severity and age, and adjusted for baseline characteristics. Outcomes were various care pathway and treatment variables, and 6-month measures of functional outcome, health-related quality of life (HRQoL), post-concussion symptoms (PCS), and mental health symptoms. The study included 2862 adults (36% women) with mild (mTBI; Glasgow Coma Scale [GCS] score 13-15), and 1333 adults (26% women) with moderate/severe TBI (GCS score 3-12). Women were less likely to be admitted to the intensive care unit (ICU; odds ratios [OR] 0.6, 95% confidence interval [CI]: 0.4-0.8) following mTBI. Following moderate/severe TBI, women had a shorter median hospital stay (OR 0.7, 95% CI: 0.5-1.0). Following mTBI, women had poorer outcomes; lower Glasgow Outcome Scale Extended (GOSE; OR 1.4, 95% CI: 1.2-1.6), lower generic and disease-specific HRQoL, and more severe PCS, depression, and anxiety. Among them, women under age 45 and above age 65 years showed worse 6-month outcomes compared with men of the same age. Following moderate/severe TBI, there was no difference in GOSE (OR 0.9, 95% CI: 0.7-1.2), but women reported more severe PCS (OR 1.7, 95% CI: 1.1-2.6). Men and women differ in care pathways and outcomes following TBI. Women generally report worse 6-month outcomes, but the size of differences depend on TBI severity and age. Future studies should examine factors that explain these differences.",
keywords = "care pathway, outcomes, sex differences, traumatic brain injury, treatment",
author = "Ana Mikoli{\'c} and {van Klaveren}, David and {Oude Groeniger}, Joost and Wiegers, {Eveline J A} and Lingsma, {Hester F} and Marina Zeldovich and {von Steinb{\"u}chel}, Nicole and Maas, {Andrew I R} and {Roeters van Lennep}, {Jeanine E} and Suzanne Polinder and {CENTER-TBI Participants and Investigators} and Daniel Kondziella and Fabricius, {Martin Ejler}",
year = "2021",
month = jan,
day = "15",
doi = "10.1089/neu.2020.7228",
language = "English",
volume = "38",
pages = "235--251",
journal = "Journal of Neurotrauma",
issn = "0897-7151",
publisher = "Mary Ann Liebert Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury

AU - Mikolić, Ana

AU - van Klaveren, David

AU - Oude Groeniger, Joost

AU - Wiegers, Eveline J A

AU - Lingsma, Hester F

AU - Zeldovich, Marina

AU - von Steinbüchel, Nicole

AU - Maas, Andrew I R

AU - Roeters van Lennep, Jeanine E

AU - Polinder, Suzanne

AU - CENTER-TBI Participants and Investigators

A2 - Kondziella, Daniel

A2 - Fabricius, Martin Ejler

PY - 2021/1/15

Y1 - 2021/1/15

N2 - Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care pathways, treatment characteristics, and outcomes following mild and moderate/severe TBI. We performed mixed-effects regression analyses in the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, stratified for injury severity and age, and adjusted for baseline characteristics. Outcomes were various care pathway and treatment variables, and 6-month measures of functional outcome, health-related quality of life (HRQoL), post-concussion symptoms (PCS), and mental health symptoms. The study included 2862 adults (36% women) with mild (mTBI; Glasgow Coma Scale [GCS] score 13-15), and 1333 adults (26% women) with moderate/severe TBI (GCS score 3-12). Women were less likely to be admitted to the intensive care unit (ICU; odds ratios [OR] 0.6, 95% confidence interval [CI]: 0.4-0.8) following mTBI. Following moderate/severe TBI, women had a shorter median hospital stay (OR 0.7, 95% CI: 0.5-1.0). Following mTBI, women had poorer outcomes; lower Glasgow Outcome Scale Extended (GOSE; OR 1.4, 95% CI: 1.2-1.6), lower generic and disease-specific HRQoL, and more severe PCS, depression, and anxiety. Among them, women under age 45 and above age 65 years showed worse 6-month outcomes compared with men of the same age. Following moderate/severe TBI, there was no difference in GOSE (OR 0.9, 95% CI: 0.7-1.2), but women reported more severe PCS (OR 1.7, 95% CI: 1.1-2.6). Men and women differ in care pathways and outcomes following TBI. Women generally report worse 6-month outcomes, but the size of differences depend on TBI severity and age. Future studies should examine factors that explain these differences.

AB - Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care pathways, treatment characteristics, and outcomes following mild and moderate/severe TBI. We performed mixed-effects regression analyses in the prospective multi-center Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study, stratified for injury severity and age, and adjusted for baseline characteristics. Outcomes were various care pathway and treatment variables, and 6-month measures of functional outcome, health-related quality of life (HRQoL), post-concussion symptoms (PCS), and mental health symptoms. The study included 2862 adults (36% women) with mild (mTBI; Glasgow Coma Scale [GCS] score 13-15), and 1333 adults (26% women) with moderate/severe TBI (GCS score 3-12). Women were less likely to be admitted to the intensive care unit (ICU; odds ratios [OR] 0.6, 95% confidence interval [CI]: 0.4-0.8) following mTBI. Following moderate/severe TBI, women had a shorter median hospital stay (OR 0.7, 95% CI: 0.5-1.0). Following mTBI, women had poorer outcomes; lower Glasgow Outcome Scale Extended (GOSE; OR 1.4, 95% CI: 1.2-1.6), lower generic and disease-specific HRQoL, and more severe PCS, depression, and anxiety. Among them, women under age 45 and above age 65 years showed worse 6-month outcomes compared with men of the same age. Following moderate/severe TBI, there was no difference in GOSE (OR 0.9, 95% CI: 0.7-1.2), but women reported more severe PCS (OR 1.7, 95% CI: 1.1-2.6). Men and women differ in care pathways and outcomes following TBI. Women generally report worse 6-month outcomes, but the size of differences depend on TBI severity and age. Future studies should examine factors that explain these differences.

KW - care pathway

KW - outcomes

KW - sex differences

KW - traumatic brain injury

KW - treatment

UR - http://www.scopus.com/inward/record.url?scp=85092467317&partnerID=8YFLogxK

U2 - 10.1089/neu.2020.7228

DO - 10.1089/neu.2020.7228

M3 - Journal article

C2 - 32838645

VL - 38

SP - 235

EP - 251

JO - Journal of Neurotrauma

JF - Journal of Neurotrauma

SN - 0897-7151

IS - 2

ER -

ID: 61291360