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Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study

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Harvard

Walsh, SLF, Maher, TM, Kolb, M, Poletti, V, Nusser, R, Richeldi, L, Vancheri, C, Wilsher, ML, Antoniou, KM, Behr, J, Bendstrup, E, Brown, K, Calandriello, L, Corte, TJ, Cottin, V, Crestani, B, Flaherty, K, Glaspole, I, Grutters, J, Inoue, Y, Kokosi, M, Kondoh, Y, Kouranos, V, Kreuter, M, Johannson, K, Judge, E, Ley, B, Margaritopoulos, G, Martinez, FJ, Molina-Molina, M, Morais, A, Nunes, H, Raghu, G, Ryerson, CJ, Selman, M, Spagnolo, P, Taniguchi, H, Tomassetti, S, Valeyre, D, Wijsenbeek, M, Wuyts, W, Hansell, D, Wells, A, IPF Project Consortium (Michael Perch, Jesper Kjærgaard, mermbers), Perch, M & Kjærgaard, J 2017, 'Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study', European Respiratory Journal, bind 50, nr. 2, s. e1700936. https://doi.org/10.1183/13993003.00936-2017

APA

Walsh, S. L. F., Maher, T. M., Kolb, M., Poletti, V., Nusser, R., Richeldi, L., Vancheri, C., Wilsher, M. L., Antoniou, K. M., Behr, J., Bendstrup, E., Brown, K., Calandriello, L., Corte, T. J., Cottin, V., Crestani, B., Flaherty, K., Glaspole, I., Grutters, J., ... Kjærgaard, J. (2017). Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study. European Respiratory Journal, 50(2), e1700936. https://doi.org/10.1183/13993003.00936-2017

CBE

Walsh SLF, Maher TM, Kolb M, Poletti V, Nusser R, Richeldi L, Vancheri C, Wilsher ML, Antoniou KM, Behr J, Bendstrup E, Brown K, Calandriello L, Corte TJ, Cottin V, Crestani B, Flaherty K, Glaspole I, Grutters J, Inoue Y, Kokosi M, Kondoh Y, Kouranos V, Kreuter M, Johannson K, Judge E, Ley B, Margaritopoulos G, Martinez FJ, Molina-Molina M, Morais A, Nunes H, Raghu G, Ryerson CJ, Selman M, Spagnolo P, Taniguchi H, Tomassetti S, Valeyre D, Wijsenbeek M, Wuyts W, Hansell D, Wells A, IPF Project Consortium (Michael Perch, Jesper Kjærgaard, mermbers), Perch M, Kjærgaard J. 2017. Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study. European Respiratory Journal. 50(2):e1700936. https://doi.org/10.1183/13993003.00936-2017

MLA

Vancouver

Author

Walsh, Simon L F ; Maher, Toby M ; Kolb, Martin ; Poletti, Venerino ; Nusser, Richard ; Richeldi, Luca ; Vancheri, Carlo ; Wilsher, Margaret L ; Antoniou, Katerina M ; Behr, Jüergen ; Bendstrup, Elisabeth ; Brown, Kevin ; Calandriello, Lucio ; Corte, Tamera J ; Cottin, Vincent ; Crestani, Bruno ; Flaherty, Kevin ; Glaspole, Ian ; Grutters, Jan ; Inoue, Yoshikazu ; Kokosi, Maria ; Kondoh, Yasuhiro ; Kouranos, Vasileios ; Kreuter, Michael ; Johannson, Kerri ; Judge, Eoin ; Ley, Brett ; Margaritopoulos, George ; Martinez, Fernando J ; Molina-Molina, Maria ; Morais, António ; Nunes, Hilario ; Raghu, Ganesh ; Ryerson, Christopher J ; Selman, Moises ; Spagnolo, Paolo ; Taniguchi, Hiroyuki ; Tomassetti, Sara ; Valeyre, Dominique ; Wijsenbeek, Marlies ; Wuyts, Wim ; Hansell, David ; Wells, Athol ; IPF Project Consortium (Michael Perch, Jesper Kjærgaard, mermbers) ; Perch, Michael ; Kjærgaard, Jesper. / Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis : an international case-cohort study. I: European Respiratory Journal. 2017 ; Bind 50, Nr. 2. s. e1700936.

Bibtex

@article{4ee682fd3b5e4432b184428ed520f195,
title = "Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis: an international case-cohort study",
abstract = "We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts.A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the C-index.A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53-0.72, p<0.0001) than academic physicians (κw=0.56, IQR 0.45-0.65, p<0.0001) or physicians with access to multidisciplinary team (MDT) meetings (κw=0.54, IQR 0.45-0.64, p<0.0001). The prognostic accuracy of academic physicians with >20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75).Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts.",
keywords = "Journal Article",
author = "Walsh, {Simon L F} and Maher, {Toby M} and Martin Kolb and Venerino Poletti and Richard Nusser and Luca Richeldi and Carlo Vancheri and Wilsher, {Margaret L} and Antoniou, {Katerina M} and J{\"u}ergen Behr and Elisabeth Bendstrup and Kevin Brown and Lucio Calandriello and Corte, {Tamera J} and Vincent Cottin and Bruno Crestani and Kevin Flaherty and Ian Glaspole and Jan Grutters and Yoshikazu Inoue and Maria Kokosi and Yasuhiro Kondoh and Vasileios Kouranos and Michael Kreuter and Kerri Johannson and Eoin Judge and Brett Ley and George Margaritopoulos and Martinez, {Fernando J} and Maria Molina-Molina and Ant{\'o}nio Morais and Hilario Nunes and Ganesh Raghu and Ryerson, {Christopher J} and Moises Selman and Paolo Spagnolo and Hiroyuki Taniguchi and Sara Tomassetti and Dominique Valeyre and Marlies Wijsenbeek and Wim Wuyts and David Hansell and Athol Wells and {IPF Project Consortium (Michael Perch, Jesper Kj{\ae}rgaard, mermbers)} and Michael Perch and Jesper Kj{\ae}rgaard",
note = "Copyright {\textcopyright}ERS 2017.",
year = "2017",
month = aug,
doi = "10.1183/13993003.00936-2017",
language = "English",
volume = "50",
pages = "e1700936",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "2",

}

RIS

TY - JOUR

T1 - Diagnostic accuracy of a clinical diagnosis of idiopathic pulmonary fibrosis

T2 - an international case-cohort study

AU - Walsh, Simon L F

AU - Maher, Toby M

AU - Kolb, Martin

AU - Poletti, Venerino

AU - Nusser, Richard

AU - Richeldi, Luca

AU - Vancheri, Carlo

AU - Wilsher, Margaret L

AU - Antoniou, Katerina M

AU - Behr, Jüergen

AU - Bendstrup, Elisabeth

AU - Brown, Kevin

AU - Calandriello, Lucio

AU - Corte, Tamera J

AU - Cottin, Vincent

AU - Crestani, Bruno

AU - Flaherty, Kevin

AU - Glaspole, Ian

AU - Grutters, Jan

AU - Inoue, Yoshikazu

AU - Kokosi, Maria

AU - Kondoh, Yasuhiro

AU - Kouranos, Vasileios

AU - Kreuter, Michael

AU - Johannson, Kerri

AU - Judge, Eoin

AU - Ley, Brett

AU - Margaritopoulos, George

AU - Martinez, Fernando J

AU - Molina-Molina, Maria

AU - Morais, António

AU - Nunes, Hilario

AU - Raghu, Ganesh

AU - Ryerson, Christopher J

AU - Selman, Moises

AU - Spagnolo, Paolo

AU - Taniguchi, Hiroyuki

AU - Tomassetti, Sara

AU - Valeyre, Dominique

AU - Wijsenbeek, Marlies

AU - Wuyts, Wim

AU - Hansell, David

AU - Wells, Athol

AU - IPF Project Consortium (Michael Perch, Jesper Kjærgaard, mermbers)

A2 - Perch, Michael

A2 - Kjærgaard, Jesper

N1 - Copyright ©ERS 2017.

PY - 2017/8

Y1 - 2017/8

N2 - We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts.A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the C-index.A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53-0.72, p<0.0001) than academic physicians (κw=0.56, IQR 0.45-0.65, p<0.0001) or physicians with access to multidisciplinary team (MDT) meetings (κw=0.54, IQR 0.45-0.64, p<0.0001). The prognostic accuracy of academic physicians with >20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75).Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts.

AB - We conducted an international study of idiopathic pulmonary fibrosis (IPF) diagnosis among a large group of physicians and compared their diagnostic performance to a panel of IPF experts.A total of 1141 respiratory physicians and 34 IPF experts participated. Participants evaluated 60 cases of interstitial lung disease (ILD) without interdisciplinary consultation. Diagnostic agreement was measured using the weighted kappa coefficient (κw). Prognostic discrimination between IPF and other ILDs was used to validate diagnostic accuracy for first-choice diagnoses of IPF and were compared using the C-index.A total of 404 physicians completed the study. Agreement for IPF diagnosis was higher among expert physicians (κw=0.65, IQR 0.53-0.72, p<0.0001) than academic physicians (κw=0.56, IQR 0.45-0.65, p<0.0001) or physicians with access to multidisciplinary team (MDT) meetings (κw=0.54, IQR 0.45-0.64, p<0.0001). The prognostic accuracy of academic physicians with >20 years of experience (C-index=0.72, IQR 0.0-0.73, p=0.229) and non-university hospital physicians with more than 20 years of experience, attending weekly MDT meetings (C-index=0.72, IQR 0.70-0.72, p=0.052), did not differ significantly (p=0.229 and p=0.052 respectively) from the expert panel (C-index=0.74 IQR 0.72-0.75).Experienced respiratory physicians at university-based institutions diagnose IPF with similar prognostic accuracy to IPF experts. Regular MDT meeting attendance improves the prognostic accuracy of experienced non-university practitioners to levels achieved by IPF experts.

KW - Journal Article

U2 - 10.1183/13993003.00936-2017

DO - 10.1183/13993003.00936-2017

M3 - Journal article

C2 - 28860269

VL - 50

SP - e1700936

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 2

ER -

ID: 52686349