Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Development of Preliminary Remission Criteria for Gout Using Delphi and 1000Minds® Consensus Exercises

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Sex Differences in the Achievement of Remission and Low Disease Activity in Rheumatoid Arthritis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Growth and puberty in juvenile dermatomyositis: a longitudinal cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Antinuclear Antibody-Negative Systemic Lupus Erythematosus in an International Inception Cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Specificity of Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Assessing the Sensitivity to Change of the OMERACT Ultrasound Structural Gout Lesions During Urate- Lowering Therapy

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  3. Evaluating the OMERACT Defi nitions of Ultrasound Gout Structural Lesions in the Diagnosis of Gout

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  • Hugh de Lautour
  • William J Taylor
  • Ade Adebajo
  • Rieke Alten
  • Ruben Burgos-Vargas
  • Peter Chapman
  • Marco A Cimmino
  • Geraldo da Rocha Castelar Pinheiro
  • Ric Day
  • Leslie R Harrold
  • Philip Helliwell
  • Matthijs Janssen
  • Gail Kerr
  • Arthur Kavanaugh
  • Dinesh Khanna
  • Puja P Khanna
  • Chingtsai Lin
  • Worawit Louthrenoo
  • Geraldine McCarthy
  • Janitzia Vazquez-Mellado
  • Ted R Mikuls
  • Tuhina Neogi
  • Alexis Ogdie
  • Fernando Perez-Ruiz
  • Naomi Schlesinger
  • H Ralph Schumacher
  • Carlo A Scirè
  • Jasvinder A Singh
  • Francisca Sivera
  • Ole Slot
  • Lisa K Stamp
  • Anne-Kathrin Tausche
  • Robert Terkeltaub
  • Till Uhlig
  • Mart van de Laar
  • Douglas White
  • Hisashi Yamanaka
  • Xuejun Zeng
  • Nicola Dalbeth
Vis graf over relationer

OBJECTIVES: The aim of this study was to establish consensus for potential remission criteria for use in clinical trials of gout.

METHODS: Experts (n=88) in gout from multiple countries were invited to participate in a web-based questionnaire study. Three rounds of Delphi consensus exercises were conducted using SurveyMonkey® followed by a discrete choice experiment using 1000Minds®. The exercises focused on identifying domains, definitions for each domain and the timeframe over which remission should be defined.

RESULTS: There were 49 respondents (56% response) to the initial survey with subsequent response rates ranging from 57% to 90%. Consensus was reached for the inclusion of serum urate (98% agreement), flares (96%), tophi (92%), pain (83%) and patient global assessment (93%) of disease activity as measurement domains in remission criteria. Consensus was also reached for domain definitions including serum urate (< 0.36mM), pain (<2 on a 10-point scale) and patient global assessment (<2 on a 10-point scale), all of which should be measured at least twice over a set time interval. Consensus was not achieved in the Delphi exercise for the timeframe for remission with equal responses for six months (51%) and one year (49%). In the discrete choice experiment, there was a preference towards 12 months as a timeframe for remission.

CONCLUSION: These consensus exercises have identified domains and provisional definitions for gout remission criteria. Based on the results of these exercises, preliminary remission criteria are proposed with domains of serum urate, acute flares, tophus, pain and patient global assessment. These preliminary criteria now require testing in clinical datasets. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftArthritis Care & Research
Vol/bind68
Udgave nummer5
Sider (fra-til)667-72
Antal sider6
ISSN2151-464X
DOI
StatusUdgivet - 2016

ID: 46213167