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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Development of a (11)C-labeled tetrazine for rapid tetrazine-trans-cyclooctene ligation

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Tetrazine-trans-cyclooctene ligations are remarkably fast and selective reactions even at low micro-molar concentrations. In bioorthogonal radiochemistry, tools that enable conjugation of radioactive probes to pre-targeted vectors are of great interest. Herein, we describe the successful development of the first (11)C-labelled tetrazine and its reaction with trans-cyclooctenol.
OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind49
Udgave nummer36
Sider (fra-til)3805-7
Antal sider3
ISSN1359-7345
DOI
StatusUdgivet - 2013

ID: 38389139