Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Current status of human papillomavirus positivity in oropharyngeal squamous cell carcinoma in Europe: a systematic review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{f3f6809187c24e5b9569efd51a23e237,
title = "Current status of human papillomavirus positivity in oropharyngeal squamous cell carcinoma in Europe: a systematic review",
abstract = "Background: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in the Western world in recent years. Human papillomavirus (HPV) infection is established as the main explanation. Aims/objectives: This study aims to review the most recently published studies on the repartition of HPV-positive OPSCC in Europe. Method and material: PubMed and Embase were systematically searched for articles addressing the distribution of HPV-positive and HPV-negative cases among OPSCC patients in Europe. Articles published in the period 2014-2018, with a study period including 2013 and the following years were included. The presence of HPV DNA and p16 overexpression, either solely or together, were accepted as indicators of HPV-positivity. Information on the anatomical sublocation of the tumour, definition of HPV-status, HPV type, HPV status, age, sex, TNM-stage, smoking habits and alcohol consumption were extracted. Results: Seven articles (n = 2075 patients, range: 22-926 patients per study) from seven European countries were included. The repartition of HPV-positivity ranged from 18{\%} to 65{\%}. The lowest occurrence of HPV-positivity was seen in Greece and the Netherlands, and the highest in Sweden and Denmark. Conclusion/significance: The highest share of HPV-positive patients with up to 65{\%} was found in Nordic countries. The lowest share was found in Central and Southern European countries.",
keywords = "human papillomavirus (HPV), incidence, Oropharyngeal squamous cell carcinoma, oropharynx",
author = "Stjernstr{\o}m, {Karoline Dyrberg} and Jensen, {Jakob Schmidt} and Jakobsen, {Kathrine Kronberg} and Christian Gr{\o}nh{\o}j and {von Buchwald}, Christian",
year = "2019",
month = "12",
doi = "10.1080/00016489.2019.1669820",
language = "English",
volume = "139",
pages = "1112--1116",
journal = "Acta Oto-Laryngologica",
issn = "0001-6489",
publisher = "Informa Healthcare",
number = "12",

}

RIS

TY - JOUR

T1 - Current status of human papillomavirus positivity in oropharyngeal squamous cell carcinoma in Europe

T2 - a systematic review

AU - Stjernstrøm, Karoline Dyrberg

AU - Jensen, Jakob Schmidt

AU - Jakobsen, Kathrine Kronberg

AU - Grønhøj, Christian

AU - von Buchwald, Christian

PY - 2019/12

Y1 - 2019/12

N2 - Background: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in the Western world in recent years. Human papillomavirus (HPV) infection is established as the main explanation. Aims/objectives: This study aims to review the most recently published studies on the repartition of HPV-positive OPSCC in Europe. Method and material: PubMed and Embase were systematically searched for articles addressing the distribution of HPV-positive and HPV-negative cases among OPSCC patients in Europe. Articles published in the period 2014-2018, with a study period including 2013 and the following years were included. The presence of HPV DNA and p16 overexpression, either solely or together, were accepted as indicators of HPV-positivity. Information on the anatomical sublocation of the tumour, definition of HPV-status, HPV type, HPV status, age, sex, TNM-stage, smoking habits and alcohol consumption were extracted. Results: Seven articles (n = 2075 patients, range: 22-926 patients per study) from seven European countries were included. The repartition of HPV-positivity ranged from 18% to 65%. The lowest occurrence of HPV-positivity was seen in Greece and the Netherlands, and the highest in Sweden and Denmark. Conclusion/significance: The highest share of HPV-positive patients with up to 65% was found in Nordic countries. The lowest share was found in Central and Southern European countries.

AB - Background: The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has been rising in the Western world in recent years. Human papillomavirus (HPV) infection is established as the main explanation. Aims/objectives: This study aims to review the most recently published studies on the repartition of HPV-positive OPSCC in Europe. Method and material: PubMed and Embase were systematically searched for articles addressing the distribution of HPV-positive and HPV-negative cases among OPSCC patients in Europe. Articles published in the period 2014-2018, with a study period including 2013 and the following years were included. The presence of HPV DNA and p16 overexpression, either solely or together, were accepted as indicators of HPV-positivity. Information on the anatomical sublocation of the tumour, definition of HPV-status, HPV type, HPV status, age, sex, TNM-stage, smoking habits and alcohol consumption were extracted. Results: Seven articles (n = 2075 patients, range: 22-926 patients per study) from seven European countries were included. The repartition of HPV-positivity ranged from 18% to 65%. The lowest occurrence of HPV-positivity was seen in Greece and the Netherlands, and the highest in Sweden and Denmark. Conclusion/significance: The highest share of HPV-positive patients with up to 65% was found in Nordic countries. The lowest share was found in Central and Southern European countries.

KW - human papillomavirus (HPV)

KW - incidence

KW - Oropharyngeal squamous cell carcinoma

KW - oropharynx

UR - http://www.scopus.com/inward/record.url?scp=85073921080&partnerID=8YFLogxK

U2 - 10.1080/00016489.2019.1669820

DO - 10.1080/00016489.2019.1669820

M3 - Review

VL - 139

SP - 1112

EP - 1116

JO - Acta Oto-Laryngologica

JF - Acta Oto-Laryngologica

SN - 0001-6489

IS - 12

ER -

ID: 58345931