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Rigshospitalet - en del af Københavns Universitetshospital
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Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache

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  3. CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine

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  5. Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Katherine M Siewert
  • Derek Klarin
  • Scott M Damrauer
  • Kyong-Mi Chang
  • Philip S Tsao
  • Themistocles L Assimes
  • George Davey Smith
  • Benjamin F Voight
  • The International Headache Genetics Consortium
  • Thomas Folkmann Hansen (Medlem af forfattergruppering)
  • Jes Olesen (Medlem af forfattergruppering)
  • Ann-Louise Esserlind (Medlem af forfattergruppering)
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BACKGROUND: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized.

METHODS: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these phenotypes and migraine, using Mendelian randomization. In addition, we attempted replication of our findings in an independent genome-wide association study (GWAS) when available.

RESULTS: We report multiple phenotypes with genetic correlation (P  < 1.06 × 10-3) with migraine, including heart disease, type 2 diabetes, lipid levels, blood pressure, autoimmune and psychiatric phenotypes. In particular, we find evidence that blood pressure directly contributes to migraine and explains a previously suggested causal relationship between calcium and migraine.

CONCLUSIONS: This is the largest genetic correlation analysis of migraine headache to date, both in terms of migraine GWAS sample size and the number of phenotypes tested. We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine-associated loci.

OriginalsprogEngelsk
TidsskriftInternational Journal of Epidemiology
Vol/bind49
Udgave nummer3
Sider (fra-til)1022-1031
Antal sider10
ISSN0300-5771
DOI
StatusUdgivet - 1 jun. 2020

Bibliografisk note

© The Author(s) 2020. Published by Oxford University Press on behalf of the International Epidemiological Association.

ID: 68507074