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Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

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Author

Bergsten, Helena ; Madsen, Martin Bruun ; Bergey, Francois ; Hyldegaard, Ole ; Skrede, Steinar ; Arnell, Per ; Oppegaard, Oddvar ; Itzek, Andreas ; Perner, Anders ; Svensson, Mattias ; Norrby-Teglund, Anna ; INFECT study group. / Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections. I: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 ; Bind 71, Nr. 7. s. 1772-1775.

Bibtex

@article{adcb065e8ca9445c82264fe1e51c1b9f,
title = "Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections",
abstract = "Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.",
keywords = "Streptococcus pyogenes, intravenous immunoglobulin G, necrotizing fasciitis, necrotizing soft tissue infections, superantigens",
author = "Helena Bergsten and Madsen, {Martin Bruun} and Francois Bergey and Ole Hyldegaard and Steinar Skrede and Per Arnell and Oddvar Oppegaard and Andreas Itzek and Anders Perner and Mattias Svensson and Anna Norrby-Teglund and {INFECT study group}",
note = "{\textcopyright} The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.",
year = "2020",
month = oct,
day = "23",
doi = "10.1093/cid/ciaa022",
language = "English",
volume = "71",
pages = "1772--1775",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "University of Chicago Press",
number = "7",

}

RIS

TY - JOUR

T1 - Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

AU - Bergsten, Helena

AU - Madsen, Martin Bruun

AU - Bergey, Francois

AU - Hyldegaard, Ole

AU - Skrede, Steinar

AU - Arnell, Per

AU - Oppegaard, Oddvar

AU - Itzek, Andreas

AU - Perner, Anders

AU - Svensson, Mattias

AU - Norrby-Teglund, Anna

AU - INFECT study group

N1 - © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

PY - 2020/10/23

Y1 - 2020/10/23

N2 - Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.

AB - Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.

KW - Streptococcus pyogenes

KW - intravenous immunoglobulin G

KW - necrotizing fasciitis

KW - necrotizing soft tissue infections

KW - superantigens

U2 - 10.1093/cid/ciaa022

DO - 10.1093/cid/ciaa022

M3 - Journal article

C2 - 31916575

VL - 71

SP - 1772

EP - 1775

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 7

ER -

ID: 59138287