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Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Copenhagen Prospective Personalized Oncology (CoPPO) - Clinical utility of using molecular profiling to select patients to phase 1 trials

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Comparative Assessment of Diagnostic Homologous Recombination Deficiency-Associated Mutational Signatures in Ovarian Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Clinical Outcomes in Patients with Multi-Hit TP53 Chronic Lymphocytic Leukemia Treated with Ibrutinib

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Detection of Molecular Signatures of Homologous Recombination Deficiency in Bladder Cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Phase I Assessment of Safety and Therapeutic Activity of BAY1436032 in Patients with IDH1-Mutant Solid Tumors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Impact of specific high-risk human papillomavirus genotypes on survival in oropharyngeal cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Personalized circulating tumor DNA in patients with hepatocellular carcinoma: a pilot study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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PURPOSE: We evaluated the clinical benefit of tumor molecular profiling (MP) to select treatment in the phase 1 setting.

EXPERIMENTAL DESIGN: Patients with advanced solid cancers and exhausted treatment options referred to a phase 1 unit were included in a prospective single-centre single-arm open-label study (NCT02290522). Tumor biopsies were obtained for comprehensive genomic analysis including whole exome sequencing (WES) and RNA sequencing. When possible, patients were treated with regimen matched to the genomic profile. Primary endpoint was progression free survival.

RESULTS: From May 2013 to January 2017 a total of 591 patients were enrolled with 500 patients undergoing biopsy. Genomic profiles were obtained in 460 patients and a potential actionable target was identified in 352 (70%) of 500 biopsied patients. One hundred and one patients (20%) received matched treatment based on either gene mutations or RNA expression levels of targets available in early clinical trials or off-label treatment. Objective response according to RECIST1.1 was observed in 15/101 patients (0% CR, 15% PR) with a median PFS of 12 weeks (95% CI 9.9-14.4).

CONCLUSIONS: Our study supports the feasibility of genomic profiling to select patients in the phase 1 setting and suggests that genomic matching can be beneficial for a minor subset of patients with no other treatment options. Randomized studies may validate this assumption.

OriginalsprogEngelsk
TidsskriftClinical Cancer Research
Vol/bind25
Udgave nummer4
Sider (fra-til)1239-1247
Antal sider9
ISSN1078-0432
DOI
StatusUdgivet - 2019

ID: 55864659