Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Concentration of perfluorinated compounds and cotinine in human foetal organs, placenta, and maternal plasma

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Long-term exposure to road traffic noise and all-cause and cause-specific mortality: a Danish Nurse Cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Urinary concentrations of parabens and reproductive parameters in young men

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Human Oocyte Morphology and Outcomes of Infertility Treatment: a Systematic Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Use of cryopreserved ovarian tissue in the Danish fertility preservation cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Genetic insights into biological mechanisms governing human ovarian ageing

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. In vitro growth and maturation of primordial follicles and immature oocytes

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

BACKGROUND: Perfluoroalkyl substances (PFASs) are bio-accumulative pollutants, and prenatal exposure to PFASs is believed to impact human foetal development and may have long-term adverse health effects later in life. Additionally, maternal cigarette smoking may be associated with PFAS levels. Foetal exposure has previously been estimated from umbilical cord plasma, but the actual concentration in foetal organs has never been measured.

OBJECTIVES: The concentrations of 5 PFASs and cotinine - the primary metabolite of nicotine - were measured in human foetuses, placentas, and maternal plasma to evaluate to what extent these compounds were transferred from mother to foetus and to determine if the PFAS concentrations were associated with maternal cigarette smoking.

METHODS: Thirty-nine Danish women who underwent legal termination of pregnancy before gestational week 12 were included; 24 maternal blood samples were obtained together with 34 placental samples and 108 foetal organs. PFASs and cotinine were assayed by liquid chromatography/triple quadrupole mass spectrometry.

RESULTS: In foetal organs, the average concentrations of perfluorooctanesulphonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluoroundecanoic acid (PFUnDa), and perfluorodecanoic acid (PFDA) were 0.6ng/g, 0.2ng/g, 0.1ng/g, 0.1ng/g, and 0.1ng/g, respectively. A significant positive correlation was found between the exposure duration, defined as foetal age, and foetal to maternal ratio for all five PFASs and cotinine. Smokers presented 99ng/g cotinine in plasma, 108ng/g in placenta, and 61ng/g in foetal organs. No correlation between the maternal cotinine concentrations and PFAS concentrations was found.

CONCLUSIONS: PFASs were transferred from mother to foetus, however, with different efficiencies. The concentrations of PFOS, PFOA, PFNA, PFUnDA, and PFDA in foetal organs were much lower than the maternal concentrations. Furthermore, a significant correlation between the exposure duration and all of the evaluated PFASs was found. The health-compromising concentrations of these substances during foetal development are unknown.

OriginalsprogEngelsk
TidsskriftScience of the Total Environment
Vol/bind596-597
Sider (fra-til)97-105
Antal sider9
ISSN0048-9697
DOI
StatusUdgivet - 2017

ID: 50288481