Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Computed tomography quantification of emphysema in people living with HIV and uninfected controls

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. NORDSTAR - Paving the way for a new era in asthma research

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  2. ERS/TSANZ Task Force Statement on the Management of Reproduction and Pregnancy in Women with Airways Diseases

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Latent tuberculosis infection among minor asylum seekers in Denmark

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  4. European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Primary ciliary dyskinesia patients have the same P. aeruginosa clone in sinuses and lungs

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

Vis graf over relationer

People living with HIV (PLWH) may be more susceptible to the development of emphysema than uninfected individuals. We assessed prevalence and risk factors for emphysema in PLWH and uninfected controls. Spirometry and chest computed tomography scans were obtained in PLWH from the Copenhagen comorbidity in HIV infection (COCOMO) Study and in uninfected controls from the Copenhagen General Population Study (CGPS) who were aged above 40 years. Emphysema was quantified using low attenuation area below -950 Hounsfield units (%LAA-950), the 15th percentile density index (PD15) and assessed by semi-quantitative visual scales. Of 742 PLWH, 21.2% and 4.7% had emphysema according to the %LAA-950 threshold with cut-offs at 5% and 10%, respectively. Of 470 uninfected controls, these numbers were 24.3% (p=0.23) and 4.0% (p=0.68). HIV was not associated with emphysema (adjusted odds ratio 1.25 [95%CI: 0.68-2.36] for %LAA-950>10%), by PD15, or by visually assessed emphysema. We found no interaction between HIV and cumulative smoking. Breathlessness and sputum production were more common in PLWH with emphysema, and emphysema seemed to be more prevalent in PLWH with airflow limitation. HIV was therefore not independently associated with emphysema but the clinical impact of emphysema was greater in PLWH than in uninfected controls.

OriginalsprogEngelsk
TidsskriftThe European Respiratory Journal
Vol/bind52
Udgave nummer1
Sider (fra-til)1800296
ISSN0903-1936
DOI
StatusUdgivet - 2018

ID: 54604116