Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Comparison of four MRI protocols for detection of extrahepatic colorectal cancer metastases

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Brain capillary transit time heterogeneity in healthy volunteers measured by dynamic contrast-enhanced T1 -weighted perfusion MRI

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Comparison of global cerebral blood flow measured by phase-contrast mapping MRI with (15) O-H2 O positron emission tomography

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Estimation of intersubject variability of cerebral blood flow measurements using MRI and positron emission tomography

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Pharmacological modulation of the BOLD response: a study of acetazolamide and glyceryl trinitrate in humans

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A new mutation of the fukutin gene causing late-onset limb girdle muscular dystrophy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Plaster cast compared with bridging external fixation for distal radius fractures of the Colles' type

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Kim Sivesgaard
  • Maria Louise Jöhnk
  • Lars P Larsen
  • Michael Sørensen
  • Stine Kramer
  • Vibeke Berg Løgager
  • Flemming Hansen
  • Erik Morre Pedersen
Vis graf over relationer

PURPOSE: To compare three magnetic resonance imaging (MRI) protocols containing diffusion-weighted imaging with background suppression (DWIBS) and one traditional protocol for detecting extrahepatic colorectal cancer metastases.

MATERIALS AND METHODS: Thirty patients with extrahepatic colorectal cancer metastases were scanned in three stations from the skull base to the upper thighs using a 1.5T MRI system with six different MRI sequences; transverse and coronal T2 -weighted (T2 W) turbo spin-echo (TSE), coronal short tau inversion recovery (STIR), 3D T1 W TSE, DWIBS, and a contrast-enhanced T1 W 3D gradient echo (GRE) sequence. The six sequences were used to build four hypothetical MRI interpretive sets which were read by two readers in consensus, blinded to prior imaging. Lesions were categorized into 13 anatomic regions. Fluorodeoxyglucose / positron emission tomography / computed tomography (FDG-PET/CT) read with full access to prior imaging and clinical records was used as the reference standard. Sensitivity, specificity, and false discovery rate (FDR) were calculated as appropriate and receiver operating characteristic (ROC) curves were constructed.

RESULTS: In all, 177 malignant lesions were detected by FDG-PET/CT and distributed in 92 out of 390 scanned anatomic regions. The sensitivity was statistically higher in two out of three sets incorporating DWIBS on a per-lesion basis (66.7%, 63.3%, and 66.7% vs. 57.6%) (P = 0.01, P = 0.11, and P = 0.01, respectively) and in all sets incorporating DWIBS on a per-region basis (75.0%, 75.0%, and 77.2 vs. 66.3%) (P = 0.04, P = 0.04, and P = 0.01, respectively). There was no difference in specificity, FDR, or AUCROC . There was no difference between sets containing DWIBS irrespective of the use of a contrast-enhanced sequence.

CONCLUSION: MRI sets containing DWIBS had superior sensitivity. This sensitivity was retained when omitting a contrast-enhanced sequence.

LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1619-1630.

OriginalsprogEngelsk
TidsskriftJournal of magnetic resonance imaging : JMRI
Vol/bind46
Udgave nummer6
Sider (fra-til)1619-1630
Antal sider12
ISSN1053-1807
DOI
StatusUdgivet - dec. 2017

Bibliografisk note

© 2017 International Society for Magnetic Resonance in Medicine.

ID: 59376077