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Comparative effectiveness of coronary artery stenosis and atherosclerotic plaque burden assessment for predicting 30-day revascularization and 2-year major adverse cardiac events

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Harvard

Kishi, S, Magalhães, TA, Cerci, RJ, Zimmermann, E, Matheson, MB, Vavere, A, Tanami, Y, Kitslaar, PH, George, RT, Brinker, J, Miller, JM, Clouse, ME, Lemos, PA, Niinuma, H, Reiber, JHC, Kofoed, KF, Rochitte, CE, Rybicki, FJ, Di Carli, MF, Cox, C, Lima, JAC & Arbab-Zadeh, A 2020, 'Comparative effectiveness of coronary artery stenosis and atherosclerotic plaque burden assessment for predicting 30-day revascularization and 2-year major adverse cardiac events', The international journal of cardiovascular imaging, bind 36, nr. 12, s. 2365-2375. https://doi.org/10.1007/s10554-020-01851-3

APA

Kishi, S., Magalhães, T. A., Cerci, R. J., Zimmermann, E., Matheson, M. B., Vavere, A., Tanami, Y., Kitslaar, P. H., George, R. T., Brinker, J., Miller, J. M., Clouse, M. E., Lemos, P. A., Niinuma, H., Reiber, J. H. C., Kofoed, K. F., Rochitte, C. E., Rybicki, F. J., Di Carli, M. F., ... Arbab-Zadeh, A. (2020). Comparative effectiveness of coronary artery stenosis and atherosclerotic plaque burden assessment for predicting 30-day revascularization and 2-year major adverse cardiac events. The international journal of cardiovascular imaging, 36(12), 2365-2375. https://doi.org/10.1007/s10554-020-01851-3

CBE

Kishi S, Magalhães TA, Cerci RJ, Zimmermann E, Matheson MB, Vavere A, Tanami Y, Kitslaar PH, George RT, Brinker J, Miller JM, Clouse ME, Lemos PA, Niinuma H, Reiber JHC, Kofoed KF, Rochitte CE, Rybicki FJ, Di Carli MF, Cox C, Lima JAC, Arbab-Zadeh A. 2020. Comparative effectiveness of coronary artery stenosis and atherosclerotic plaque burden assessment for predicting 30-day revascularization and 2-year major adverse cardiac events. The international journal of cardiovascular imaging. 36(12):2365-2375. https://doi.org/10.1007/s10554-020-01851-3

MLA

Vancouver

Author

Kishi, Satoru ; Magalhães, Tiago A ; Cerci, Rodrigo J ; Zimmermann, Elke ; Matheson, Matthew B ; Vavere, Andrea ; Tanami, Yutaka ; Kitslaar, Pieter H ; George, Richard T ; Brinker, Jeffrey ; Miller, Julie M ; Clouse, Melvin E ; Lemos, Pedro A ; Niinuma, Hiroyuki ; Reiber, Johan H C ; Kofoed, Klaus F ; Rochitte, Carlos E ; Rybicki, Frank J ; Di Carli, Marcelo F ; Cox, Christopher ; Lima, Joao A C ; Arbab-Zadeh, Armin. / Comparative effectiveness of coronary artery stenosis and atherosclerotic plaque burden assessment for predicting 30-day revascularization and 2-year major adverse cardiac events. I: The international journal of cardiovascular imaging. 2020 ; Bind 36, Nr. 12. s. 2365-2375.

Bibtex

@article{1a772ebd12a8401dbbeb757a9f436566,
title = "Comparative effectiveness of coronary artery stenosis and atherosclerotic plaque burden assessment for predicting 30-day revascularization and 2-year major adverse cardiac events",
abstract = "PURPOSE: To provide comparative prognostic information of coronary atherosclerotic plaque volume and stenosis assessment in patients with suspected coronary artery disease (CAD).METHODS: We followed 372 patients with suspected or known CAD enrolled in the CORE320 study for 2 years after baseline 320-detector row cardiac CT scanning and invasive quantitative coronary angiography (QCA). CT images were analyzed for coronary calcium scanning (CACS), semi-automatically derived total percent atheroma volume (PAV), segment stenosis score (SSS), in addition to traditional stenosis assessment (≥ 50%) by CT and QCA for (1) 30-day revascularization and (2) major adverse cardiac events (MACE). Area under the receiver operating characteristic curve (AUC) was used to compare accuracy of risk prediction.RESULTS: Sixty percent of patients had obstructive CAD by QCA with 23% undergoing 30-day revascularization and 9% experiencing MACE at 2 years. Most late events (20/32) were revascularization procedures. Prediction of 30-day revascularization was modest (AUC range 0.67-0.78) but improved after excluding patients with known CAD (AUC range 0.73-0.86, p < 0.05 for all). Similarly, prediction of MACE improved after excluding patients with known CAD (AUC range 0.58-0.73 vs. 0.63-0.77). CT metrics of atherosclerosis burden performed overall similarly but stenosis assessment was superior for predicting 30-day revascularization.CONCLUSIONS: Angiographic and coronary atherosclerotic plaque metrics perform only modestly well for predicting 30-day revascularization and 2-year MACE in high risk patients but improve after excluding patients with known CAD. Atherosclerotic plaque metrics did not yield incremental value over stenosis assessment for predicting events that predominantly consisted of revascularization procedures.CLINICAL TRIAL REGISTRATION: NCT00934037.",
keywords = "Aged, Comparative Effectiveness Research, Computed Tomography Angiography, Coronary Angiography, Coronary Artery Disease/diagnostic imaging, Coronary Stenosis/diagnostic imaging, Coronary Vessels/diagnostic imaging, Disease Progression, Female, Heart Disease Risk Factors, Humans, Male, Middle Aged, Multidetector Computed Tomography, Myocardial Revascularization, Plaque, Atherosclerotic, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Assessment, Severity of Illness Index, Time Factors",
author = "Satoru Kishi and Magalh{\~a}es, {Tiago A} and Cerci, {Rodrigo J} and Elke Zimmermann and Matheson, {Matthew B} and Andrea Vavere and Yutaka Tanami and Kitslaar, {Pieter H} and George, {Richard T} and Jeffrey Brinker and Miller, {Julie M} and Clouse, {Melvin E} and Lemos, {Pedro A} and Hiroyuki Niinuma and Reiber, {Johan H C} and Kofoed, {Klaus F} and Rochitte, {Carlos E} and Rybicki, {Frank J} and {Di Carli}, {Marcelo F} and Christopher Cox and Lima, {Joao A C} and Armin Arbab-Zadeh",
year = "2020",
month = dec,
doi = "10.1007/s10554-020-01851-3",
language = "English",
volume = "36",
pages = "2365--2375",
journal = "International Journal of Cardiovascular Imaging",
issn = "1569-5794",
publisher = "Springer Netherlands",
number = "12",

}

RIS

TY - JOUR

T1 - Comparative effectiveness of coronary artery stenosis and atherosclerotic plaque burden assessment for predicting 30-day revascularization and 2-year major adverse cardiac events

AU - Kishi, Satoru

AU - Magalhães, Tiago A

AU - Cerci, Rodrigo J

AU - Zimmermann, Elke

AU - Matheson, Matthew B

AU - Vavere, Andrea

AU - Tanami, Yutaka

AU - Kitslaar, Pieter H

AU - George, Richard T

AU - Brinker, Jeffrey

AU - Miller, Julie M

AU - Clouse, Melvin E

AU - Lemos, Pedro A

AU - Niinuma, Hiroyuki

AU - Reiber, Johan H C

AU - Kofoed, Klaus F

AU - Rochitte, Carlos E

AU - Rybicki, Frank J

AU - Di Carli, Marcelo F

AU - Cox, Christopher

AU - Lima, Joao A C

AU - Arbab-Zadeh, Armin

PY - 2020/12

Y1 - 2020/12

N2 - PURPOSE: To provide comparative prognostic information of coronary atherosclerotic plaque volume and stenosis assessment in patients with suspected coronary artery disease (CAD).METHODS: We followed 372 patients with suspected or known CAD enrolled in the CORE320 study for 2 years after baseline 320-detector row cardiac CT scanning and invasive quantitative coronary angiography (QCA). CT images were analyzed for coronary calcium scanning (CACS), semi-automatically derived total percent atheroma volume (PAV), segment stenosis score (SSS), in addition to traditional stenosis assessment (≥ 50%) by CT and QCA for (1) 30-day revascularization and (2) major adverse cardiac events (MACE). Area under the receiver operating characteristic curve (AUC) was used to compare accuracy of risk prediction.RESULTS: Sixty percent of patients had obstructive CAD by QCA with 23% undergoing 30-day revascularization and 9% experiencing MACE at 2 years. Most late events (20/32) were revascularization procedures. Prediction of 30-day revascularization was modest (AUC range 0.67-0.78) but improved after excluding patients with known CAD (AUC range 0.73-0.86, p < 0.05 for all). Similarly, prediction of MACE improved after excluding patients with known CAD (AUC range 0.58-0.73 vs. 0.63-0.77). CT metrics of atherosclerosis burden performed overall similarly but stenosis assessment was superior for predicting 30-day revascularization.CONCLUSIONS: Angiographic and coronary atherosclerotic plaque metrics perform only modestly well for predicting 30-day revascularization and 2-year MACE in high risk patients but improve after excluding patients with known CAD. Atherosclerotic plaque metrics did not yield incremental value over stenosis assessment for predicting events that predominantly consisted of revascularization procedures.CLINICAL TRIAL REGISTRATION: NCT00934037.

AB - PURPOSE: To provide comparative prognostic information of coronary atherosclerotic plaque volume and stenosis assessment in patients with suspected coronary artery disease (CAD).METHODS: We followed 372 patients with suspected or known CAD enrolled in the CORE320 study for 2 years after baseline 320-detector row cardiac CT scanning and invasive quantitative coronary angiography (QCA). CT images were analyzed for coronary calcium scanning (CACS), semi-automatically derived total percent atheroma volume (PAV), segment stenosis score (SSS), in addition to traditional stenosis assessment (≥ 50%) by CT and QCA for (1) 30-day revascularization and (2) major adverse cardiac events (MACE). Area under the receiver operating characteristic curve (AUC) was used to compare accuracy of risk prediction.RESULTS: Sixty percent of patients had obstructive CAD by QCA with 23% undergoing 30-day revascularization and 9% experiencing MACE at 2 years. Most late events (20/32) were revascularization procedures. Prediction of 30-day revascularization was modest (AUC range 0.67-0.78) but improved after excluding patients with known CAD (AUC range 0.73-0.86, p < 0.05 for all). Similarly, prediction of MACE improved after excluding patients with known CAD (AUC range 0.58-0.73 vs. 0.63-0.77). CT metrics of atherosclerosis burden performed overall similarly but stenosis assessment was superior for predicting 30-day revascularization.CONCLUSIONS: Angiographic and coronary atherosclerotic plaque metrics perform only modestly well for predicting 30-day revascularization and 2-year MACE in high risk patients but improve after excluding patients with known CAD. Atherosclerotic plaque metrics did not yield incremental value over stenosis assessment for predicting events that predominantly consisted of revascularization procedures.CLINICAL TRIAL REGISTRATION: NCT00934037.

KW - Aged

KW - Comparative Effectiveness Research

KW - Computed Tomography Angiography

KW - Coronary Angiography

KW - Coronary Artery Disease/diagnostic imaging

KW - Coronary Stenosis/diagnostic imaging

KW - Coronary Vessels/diagnostic imaging

KW - Disease Progression

KW - Female

KW - Heart Disease Risk Factors

KW - Humans

KW - Male

KW - Middle Aged

KW - Multidetector Computed Tomography

KW - Myocardial Revascularization

KW - Plaque, Atherosclerotic

KW - Predictive Value of Tests

KW - Prognosis

KW - Prospective Studies

KW - Risk Assessment

KW - Severity of Illness Index

KW - Time Factors

U2 - 10.1007/s10554-020-01851-3

DO - 10.1007/s10554-020-01851-3

M3 - Journal article

C2 - 32361925

VL - 36

SP - 2365

EP - 2375

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

SN - 1569-5794

IS - 12

ER -

ID: 61820795