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Rigshospitalet - en del af Københavns Universitetshospital
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Coagulation profile in patients undergoing video-assisted thoracoscopic lobectomy: A randomized, controlled trial

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  2. Platelet function in lung cancer patients undergoing lobectomy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cardiac procholecystokinin expression during haemodynamic changes in the mammalian heart

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Vis graf over relationer

BACKGROUND: Knowledge about the impact of Low-Molecular-Weight Heparin (LMWH) on the coagulation system in patients undergoing minimal invasive lung cancer surgery is sparse. The aim of this study was to assess the effect of LMWH on the coagulation system in patients undergoing Video-Assisted Thoracoscopic Surgery (VATS) lobectomy for primary lung cancer.

METHODS: Sixty-three patients diagnosed with primary lung cancer undergoing VATS lobectomy were randomized to either subcutaneous injection with dalteparin (Fragmin®) 5000 IE once daily or no intervention. Coagulation was assessed pre-, peri-, and the first two days postoperatively by standard coagulation blood test, thromboelastometry (ROTEM®) and thrombin generation.

RESULTS: Patients undergoing potential curative surgery for lung cancer were not hypercoagulable preoperatively. There was no statistically significant difference in the majority of the assessed coagulation parameters after LMWH, except that the no intervention group had a higher peak thrombin and a shorter INTEM clotting time on the first postoperative day and a lower fibrinogen level on the second postoperative day. A lower level of fibrin d-dimer in the LMWH group was found on the 1. and 2.postoperative day, although not statistical significant. No differences were found between the two groups in the amount of bleeding or number of thromboembolic events.

CONCLUSIONS: Use of LMWH administered once daily as thromboprophylaxis did not alter the coagulation profile per se. As the present study primarily evaluated biochemical endpoints, further studies using clinical endpoints are needed in regards of an optimized thromboprophylaxis approach.

OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind12
Udgave nummer2
Sider (fra-til)e0171809
ISSN1932-6203
DOI
StatusUdgivet - 2017

ID: 52044452