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Rigshospitalet - en del af Københavns Universitetshospital

Clinical presentation and mortality in hospitalized patients aged 80+ years with COVID-19-A retrospective cohort study

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  • Linda Katharina Karlsson
  • Lasse Hjort Jakobsen
  • Louise Hollensberg
  • Jesper Ryg
  • Mette Midttun
  • Henrik Frederiksen
  • Andreas Glenthøj
  • Anette Raskov Kodahl
  • Joanna Secher-Johnsen
  • Lene Kongsgaard Nielsen
  • Nuria Gonzalez Bofill
  • Fredrikke Christie Knudtzen
  • Cecilia Margareta Lund
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BACKGROUND: COVID-19, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has great health implications in older patients, including high mortality. In general, older patients often have atypical symptom presentations during acute illness due to a high level of comorbidity. The purpose of this study was to investigate the presentation of symptoms at hospital admissions in older patients with COVID-19 and evaluate its impact on disease outcome.

METHODS: This retrospective study included patients ≥80 years of age with a positive test for SARS-CoV-2, who were admitted to one of three medical departments in Denmark from March 1st to June 1st, 2020.

RESULTS: A total of 102 patients (47% male) with a mean age of 85 years were included. The most common symptoms at admission were fever (74%), cough (62%), and shortness of breath (54%). Furthermore, atypical symptoms like confusion (29%), difficulty walking (13%), and falls (8%) were also present. In-hospital and 30-day mortality were 31% (n = 32) and 41% (n = 42), respectively. Mortality was highest in patients with confusion (50% vs 38%) or falls (63% vs 39%), and nursing home residency prior to hospital admission was associated with higher mortality (OR 2.7, 95% CI 1.1-6.7).

CONCLUSIONS: Older patients with SARS-Cov-2 displayed classical symptoms of COVID-19 but also geriatric frailty symptoms such as confusion and walking impairments. Additionally, both in-hospital and 30-day mortality was very high. Our study highlights the need for preventive efforts to keep older people from getting COVID-19 and increased awareness of frailty among those with COVID-19.

TidsskriftArchives of Gerontology and Geriatrics
StatusUdgivet - 1 maj 2021

Bibliografisk note

Copyright © 2020. Published by Elsevier B.V.

ID: 62088990