Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Clinical outcome of stand-alone ALIF compared to posterior instrumentation for degenerative disc disease: A pilot study and a literature review

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Adaptive hybrid surgery analysis (AHSA) for adjuvant gamma knife radiosurgery treatment of vestibular schwannoma residuals

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Long-term functional outcome after decompressive suboccipital craniectomy for space-occupying cerebellar infarction

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Expanding the phenotype of filamin-C-related myofibrillar myopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Hereditary cerebral small vessel disease and stroke

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Implication of using MRI co-registered with CT in Leksell Gamma Knife(®) dose planning for patients with vestibular schwannoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. DanSpine, Rygkirurgi, Årsrapport 2017

    Publikation: Bog/antologi/afhandling/rapportRapportForskningpeer review

  2. Significant differences in morbidity when comparing adverse events for cervical and lumbar spine surgery - prospectively graded with SAVES

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  3. Lokale hæmostasemidler til anvendelse inden for hjerne- og rygkirurgi

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Anbefalinger for tværsektorielle forløb for mennesker med kroniske lænderygsmerter

    Publikation: Bog/antologi/afhandling/rapportRapportFormidling

  5. Rygkirurgi Årsrapport 2016: Rygkirurgi på baggrund af PRO-data. DaneSpine. Landsdækkende rygkirurgisk database.

    Publikation: Bog/antologi/afhandling/rapportRapportForskningpeer review

Vis graf over relationer

The objective of the article was to: a) present results from a case cohort pilot study comparing stand-alone ALIF and TLIF and, b) review the literature on studies comparing the clinical outcome of stand-alone ALIF with posterior instrumentation including TLIF or PLIF, in patients with disabling low back pain resulting from degenerative disc disease. ALIF surgery has previously been linked with certain high risk complications and unfavorable long term fusion results. Newer studies suggest that stand-alone ALIF can possibly be advantageous compared to other types of posterior instrumented interbody fusion for a selected group of DDD patients. The methods and material consisted of a cohort pilot study of patients, with DDD treated with stand-alone ALIF or TLIF followed by a literature review conducted through a comprehensive PubMed database search of the English literature. Studies comparing stand-alone ALIF with posterior instrumented interbody fusion were selected and reviewed. Results from the pilot study, n = 21, showed a reduced perioperative blood loss, shorter operative time and a trend towards better pain reduction and decreased use of opioid analgesics in patients undergoing stand-alone ALIF compared to posterior instrumented fusion with TLIF. The literature review included three studies, n = 630. All three studies were retrospective cohort studies. The average patient follow-up was 2-years but with heterogeneous selected outcomes. Two of three articles documented significant advantages when using stand-alone ALIF on outcomes such as ODI, VAS, surgical time, blood loss and patient satisfaction. No study found stand-alone ALIF inferior in chosen outcomes including fusion. In conclusion the pilot study and the literature review, finds similar clinical outcomes and fusion rates after stand-alone ALIF and posterior interbody fusion. Stand-alone ALIF was associated with a shorter duration of surgery, less perioperative blood loss and a faster improvement post-operatively. Therefore stand-alone ALIF is a viable and important surgical option, which could be considered first choice as surgical treatment.

OriginalsprogEngelsk
TidsskriftClinical Neurology and Neurosurgery
Vol/bind133
Sider (fra-til)64-9
Antal sider6
ISSN0303-8467
DOI
StatusUdgivet - jun. 2015

ID: 46292547