Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Children and adolescents previously treated with glucocorticoids display lower verbal intellectual abilities

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Paediatric hepatitis B and hepatitis C virus infections: an observational study of a Danish cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Infectious diseases detected by screening after arrival to Denmark in internationally adopted children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates. 2. Clinical part

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Cigarette smoking and cerebral blood flow in a cohort of middle-aged adults

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Diagnostic added value of electrical source imaging in presurgical evaluation of patients with epilepsy: A prospective study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

AIM: Perinatal exposure to glucocorticoids has been associated with adverse cerebral effects, but little is known about their effect on cognitive development and exposure later in childhood. This study examined intellectual abilities, memory and behavioural problems in children previously treated with glucocorticoids.

METHODS: We evaluated 38 children aged from seven to 16 years, who had been treated with glucocorticoids for rheumatic disease or nephrotic syndrome, together with 42 healthy controls matched for age, gender and parental education. The median cumulative dose of prednisolone equivalents was 158 mg/kg (range 21-723) and the mean time that had elapsed since treatment was three-and-a-half (standard deviation 2.2) years. Intellectual abilities were assessed with the Wechsler Intelligence Scale for Children and memory performance and behavioural problems with a pattern recognition memory task and the Child Behaviour Check List.

RESULTS: There were no significant differences between the groups in pattern recognition memory, perceptual organisation index or behavioural problems, but patients had a significantly lower verbal comprehension index and this difference was present in both disease groups. There were no significant dose-response relationships regarding verbal intellectual abilities.

CONCLUSION: Children and adolescents previously treated with glucocorticoids seemed to have lower intellectual verbal abilities than healthy controls.

OriginalsprogEngelsk
TidsskriftActa paediatrica
Vol/bind104
Udgave nummer8
Sider (fra-til)784-91
ISSN0803-5253
DOI
StatusUdgivet - 2015

ID: 45346127