Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Childhood reproductive hormone levels after pediatric hematopoietic stem cell transplantation in relation to adult testicular function

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Thyroid function in COVID-19 and the association with cytokine levels and mortality

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Socioeconomic status in Danish transgender persons: a nationwide register-based cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cholecystokinin and the hormone concept

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Determining minimal important change for the thyroid-related quality of life questionnaire ThyPRO

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Dynamic Changes in LH/FSH Ratios in Infants with Normal Sex Development

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Dynamic changes of reproductive hormones in male minipuberty: Temporal dissociation of Leydig- and Sertoli-cell activity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Oophorectomy and rate of dementia: a prospective cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Environmental factors in declining human fertility

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Objectives: Longitudinal assessment of testicular function after pediatric hematopoietic stem cell transplantation (HSCT) is needed to guide clinical follow-up. We investigated dynamics in male reproductive hormones after pediatric HSCT, focusing on pubertal timing and associations with testosterone deficiency and azoospermia in adulthood.

Methods: This retrospective, longitudinal study included 39 survivors median 19 years after pediatric HSCT. Serum concentrations of LH, testosterone, FSH, and inhibin B from the time of HSCT, during puberty, and into adulthood were analyzed. Pubertal timing (rise in LH and testosterone) was compared to a reference cohort of 112 healthy boys. Associations between reproductive hormone levels during puberty and adult testicular function (including semen quality) were investigated.

Results: Pubertal induction with testosterone was needed in 6/26 patients who were prepubertal at HSCT. In the remaining patients, pubertal timing was comparable to the reference cohort. However, 9/33 patients (without pubertal induction) developed testosterone deficiency in early adulthood, which was associated with higher LH levels from age 14 to 16 years. Azoospermia in adulthood was found in 18/26 patients without testosterone substitution. Higher FSH and lower inhibin B levels from mid-pubertal age were associated with azoospermia in adulthood, in patients being prepubertal at HSCT.

Conclusion: Our results indicate a substantial risk of deterioration in testicular function after pediatric HSCT, despite normal pubertal timing. Although reproductive hormone levels from mid-puberty indicated adult testicular function, prolonged follow-up into adulthood is needed in these patients, including clinical examination, reproductive hormone analysis, and semen sample for patients interested in their fertility potential.

OriginalsprogEngelsk
TidsskriftEndocrine Connections
Vol/bind10
Udgave nummer10
Sider (fra-til)1352-1365
Antal sider14
ISSN2049-3614
DOI
StatusUdgivet - 18 okt. 2021

ID: 72893286