Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Cerebrospinal fluid lactate as a marker to differentiate between community-acquired acute bacterial meningitis and aseptic meningitis/encephalitis in adults: a Danish prospective observational cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Hospitalizations for infections by age and sex: register-based study of Danish children 1977-2014

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. More than just Borrelia? A study of co-infection and etiology in erythema migrans patients from southernmost Sweden

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Fatal chronic meningitis caused by Candida dubliniensis after liver transplantation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Compression bandaging does not compromise peripheral microcirculation in patients with cellulitis of the lower leg

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Chronic Non-bacterial Osteomyelitis: A Review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

BACKGROUND: The ability of cerebrospinal fluid (CSF) lactate to distinguish between acute bacterial meningitis (ABM) and aseptic meningitis/encephalitis (AME) is debated. We assessed the diagnostic value of CSF lactate to discriminate between ABM and AME.

METHODS: We included 176 patients from a prospective adult cohort with neuroinfections. In total, 51 ABM and 125 AME patients with clinically and/or microbiologically diagnosed acute meningitis were examined with CSF-lactate and traditional markers for infection. Receiver operating characteristic (ROC) curves were used to assess diagnostic performance.

RESULTS: In CSF, lactate, leukocytes, fraction of neutrophils, protein and glucose ratio, were significantly different between the ABM and AME groups. CSF lactate had the best diagnostic value, with an area under the curve (AUC) of 0.976 (95%CI 0.966-0.997) and using a cut-off of 3.5 mmol/L a sensitivity of 96% and specificity of 85%. Antibiotic treatment before lumbar puncture had no significant effect on the AUC of CSF lactate.

CONCLUSIONS: Compared to traditional CSF-markers, CSF lactate is more accurate to distinguish between ABM and AME.

OriginalsprogEngelsk
TidsskriftInfectious diseases (London, England)
Vol/bind50
Udgave nummer7
Sider (fra-til)514-521
ISSN2374-4235
DOI
StatusUdgivet - 2018

ID: 53547229