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Burden of sudden cardiac death in persons aged 1 to 49 years: nationwide study in denmark

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@article{1451b6a9b3eb423b897ffc11c0bcfe27,
title = "Burden of sudden cardiac death in persons aged 1 to 49 years: nationwide study in denmark",
abstract = "Background- Knowledge of the burden and causes of sudden cardiac death (SCD) is sparse in persons aged <50 years; better understanding is needed to lower the risk of SCD. The aim of this study was to report SCD incidence rates and autopsy findings in persons aged 1 to 49 years. Methods and Results- All deaths in persons aged 1 to 49 years were included in 2007 to 2009. Death certificates were reviewed by 2 physicians. History of previous admissions to hospital was assessed, and discharge summaries were read. Sudden unexpected death cases were identified and autopsy reports were collected. In the 3-year study period, there were 7849 deaths of which we identified 893 (11{\%}) SCD cases. The annual incidence rate per 100 000 persons increased from 2.3 (95{\%} confidence interval, 2.0-2.7) to 21.7 (95{\%} confidence interval, 20.2-23.4) in persons aged 1 to 35 and 36 to 49 years, respectively. Coronary artery disease was the most common cause of death and was found in 158 (36{\%}) autopsied cases, followed by 135 (31{\%}) cases of sudden unexplained death. Conclusions- In a nationwide cohort of persons aged <50 years, the annual incidence rate of SCD was ≈10× higher in persons aged 36 to 49 years than in persons aged 1 to 35 years. Notably, coronary artery disease was the most common cause of SCD, followed by unexplained deaths. These findings may help in developing strategies to prevent SCD in the future.",
author = "Bjarke Risgaard and Winkel, {Bo Gregers} and Reza Jabbari and Behr, {Elijah R} and Ole Ingemann-Hansen and Thomsen, {J{\o}rgen Lange} and Ottesen, {Gyda Lolk} and Gislason, {Gunnar H} and Henning Bundgaard and Stig Hauns{\o} and Holst, {Anders Gaarsdal} and Jacob Tfelt-Hansen",
year = "2014",
month = "4",
day = "1",
doi = "10.1161/CIRCEP.113.001421",
language = "English",
volume = "7",
pages = "205--11",
journal = "Circulation: Arrhythmia and Electrophysiology",
issn = "1941-3149",
publisher = "Lippincott Williams & Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - Burden of sudden cardiac death in persons aged 1 to 49 years

T2 - nationwide study in denmark

AU - Risgaard, Bjarke

AU - Winkel, Bo Gregers

AU - Jabbari, Reza

AU - Behr, Elijah R

AU - Ingemann-Hansen, Ole

AU - Thomsen, Jørgen Lange

AU - Ottesen, Gyda Lolk

AU - Gislason, Gunnar H

AU - Bundgaard, Henning

AU - Haunsø, Stig

AU - Holst, Anders Gaarsdal

AU - Tfelt-Hansen, Jacob

PY - 2014/4/1

Y1 - 2014/4/1

N2 - Background- Knowledge of the burden and causes of sudden cardiac death (SCD) is sparse in persons aged <50 years; better understanding is needed to lower the risk of SCD. The aim of this study was to report SCD incidence rates and autopsy findings in persons aged 1 to 49 years. Methods and Results- All deaths in persons aged 1 to 49 years were included in 2007 to 2009. Death certificates were reviewed by 2 physicians. History of previous admissions to hospital was assessed, and discharge summaries were read. Sudden unexpected death cases were identified and autopsy reports were collected. In the 3-year study period, there were 7849 deaths of which we identified 893 (11%) SCD cases. The annual incidence rate per 100 000 persons increased from 2.3 (95% confidence interval, 2.0-2.7) to 21.7 (95% confidence interval, 20.2-23.4) in persons aged 1 to 35 and 36 to 49 years, respectively. Coronary artery disease was the most common cause of death and was found in 158 (36%) autopsied cases, followed by 135 (31%) cases of sudden unexplained death. Conclusions- In a nationwide cohort of persons aged <50 years, the annual incidence rate of SCD was ≈10× higher in persons aged 36 to 49 years than in persons aged 1 to 35 years. Notably, coronary artery disease was the most common cause of SCD, followed by unexplained deaths. These findings may help in developing strategies to prevent SCD in the future.

AB - Background- Knowledge of the burden and causes of sudden cardiac death (SCD) is sparse in persons aged <50 years; better understanding is needed to lower the risk of SCD. The aim of this study was to report SCD incidence rates and autopsy findings in persons aged 1 to 49 years. Methods and Results- All deaths in persons aged 1 to 49 years were included in 2007 to 2009. Death certificates were reviewed by 2 physicians. History of previous admissions to hospital was assessed, and discharge summaries were read. Sudden unexpected death cases were identified and autopsy reports were collected. In the 3-year study period, there were 7849 deaths of which we identified 893 (11%) SCD cases. The annual incidence rate per 100 000 persons increased from 2.3 (95% confidence interval, 2.0-2.7) to 21.7 (95% confidence interval, 20.2-23.4) in persons aged 1 to 35 and 36 to 49 years, respectively. Coronary artery disease was the most common cause of death and was found in 158 (36%) autopsied cases, followed by 135 (31%) cases of sudden unexplained death. Conclusions- In a nationwide cohort of persons aged <50 years, the annual incidence rate of SCD was ≈10× higher in persons aged 36 to 49 years than in persons aged 1 to 35 years. Notably, coronary artery disease was the most common cause of SCD, followed by unexplained deaths. These findings may help in developing strategies to prevent SCD in the future.

U2 - 10.1161/CIRCEP.113.001421

DO - 10.1161/CIRCEP.113.001421

M3 - Journal article

VL - 7

SP - 205

EP - 211

JO - Circulation: Arrhythmia and Electrophysiology

JF - Circulation: Arrhythmia and Electrophysiology

SN - 1941-3149

IS - 2

ER -

ID: 44293594