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Brain Derived Neurotrophic Factor: epigenetic regulation in psychiatric disorders

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@article{76884d641a2d4310971e1dfa47e0e7a3,
title = "Brain Derived Neurotrophic Factor: epigenetic regulation in psychiatric disorders",
abstract = "Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies are currently being investigated in animal models and clinical studies. However, very little is currently known about the mechanisms that deregulate BDNF gene expression in these disorders. The BDNF gene structure and tissue expression pattern is complex, controlled in humans by 9 different gene promoters. Recently, epigenetic changes at the BDNF gene locus have been proposed to provide a link between gene and environment. In this review, we will summarize the current knowledge of BDNF epigenetic regulation with respect to psychiatric disorders and describe how this information can be applied in therapy and future research.",
keywords = "Animals, Brain-Derived Neurotrophic Factor, Epigenesis, Genetic, Humans, Mental Disorders",
author = "Cathy Mitchelmore and Lene Gede",
note = "Copyright {\textcopyright} 2014 The Authors. Published by Elsevier B.V. All rights reserved.",
year = "2014",
month = oct,
day = "24",
doi = "10.1016/j.brainres.2014.06.037",
language = "English",
volume = "1586",
pages = "162--72",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Brain Derived Neurotrophic Factor

T2 - epigenetic regulation in psychiatric disorders

AU - Mitchelmore, Cathy

AU - Gede, Lene

N1 - Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

PY - 2014/10/24

Y1 - 2014/10/24

N2 - Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies are currently being investigated in animal models and clinical studies. However, very little is currently known about the mechanisms that deregulate BDNF gene expression in these disorders. The BDNF gene structure and tissue expression pattern is complex, controlled in humans by 9 different gene promoters. Recently, epigenetic changes at the BDNF gene locus have been proposed to provide a link between gene and environment. In this review, we will summarize the current knowledge of BDNF epigenetic regulation with respect to psychiatric disorders and describe how this information can be applied in therapy and future research.

AB - Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies are currently being investigated in animal models and clinical studies. However, very little is currently known about the mechanisms that deregulate BDNF gene expression in these disorders. The BDNF gene structure and tissue expression pattern is complex, controlled in humans by 9 different gene promoters. Recently, epigenetic changes at the BDNF gene locus have been proposed to provide a link between gene and environment. In this review, we will summarize the current knowledge of BDNF epigenetic regulation with respect to psychiatric disorders and describe how this information can be applied in therapy and future research.

KW - Animals

KW - Brain-Derived Neurotrophic Factor

KW - Epigenesis, Genetic

KW - Humans

KW - Mental Disorders

U2 - 10.1016/j.brainres.2014.06.037

DO - 10.1016/j.brainres.2014.06.037

M3 - Journal article

C2 - 25223903

VL - 1586

SP - 162

EP - 172

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -

ID: 45888801