Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Brain Derived Neurotrophic Factor: epigenetic regulation in psychiatric disorders

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Transcriptomic profiling of trigeminal nucleus caudalis and spinal cord dorsal horn

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. DNMT1 regulates expression of MHC class i in post-mitotic neurons

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Localization of CGRP, CGRP receptor, PACAP and glutamate in trigeminal ganglion. Relation to the blood-brain barrier

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Structural and sequence variants in patients with Silver-Russell syndrome or similar features-Curation of a disease database

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The neurobiology of social deficits in female patients with borderline personality disorder: The importance of oxytocin

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Feasibilty study on the use of methylation-specific MLPA for the 11p15 region on prenatal samples

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important functions in neuronal development and neuroplasticity. Accumulating evidence suggests that alterations in BDNF expression levels underlie a variety of psychiatric and neurological disorders. Indeed, BDNF therapies are currently being investigated in animal models and clinical studies. However, very little is currently known about the mechanisms that deregulate BDNF gene expression in these disorders. The BDNF gene structure and tissue expression pattern is complex, controlled in humans by 9 different gene promoters. Recently, epigenetic changes at the BDNF gene locus have been proposed to provide a link between gene and environment. In this review, we will summarize the current knowledge of BDNF epigenetic regulation with respect to psychiatric disorders and describe how this information can be applied in therapy and future research.

OriginalsprogEngelsk
TidsskriftBrain Research
Vol/bind1586
Sider (fra-til)162-72
Antal sider11
ISSN0006-8993
DOI
StatusUdgivet - 24 okt. 2014

ID: 45888801