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Bone turnover biomarkers in COPD patients randomized to either a regular or shortened course of corticosteroids: a substudy of the randomized controlled CORTICO-COP trial

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  • Pradeesh Sivapalan
  • Niklas R Jørgensen
  • Alexander G Mathioudakis
  • Josefin Eklöf
  • Therese Lapperre
  • Charlotte Suppli Ulrik
  • Helle F Andreassen
  • Karin Armbruster
  • Praleene Sivapalan
  • Julie Janner
  • Nina Godtfredsen
  • Ulla M Weinreich
  • Thyge L Nielsen
  • Niels Seersholm
  • Torgny Wilcke
  • Philipp Schuetz
  • Tobias W Klausen
  • Kristoffer Marså
  • Jørgen Vestbo
  • Jens-Ulrik Jensen
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BACKGROUND: Long-term treatment with corticosteroids causes loss of bone density, but the effects of using short-term high-dose systemic-corticosteroid therapy to treat acute exacerbations of chronic obstructive pulmonary disease (AECOPD) are unclear. Our aim was to determine whether high-dose corticosteroid therapy affected bone turnover markers (BTMs) to a greater extent compared to low-dose corticosteroid therapy.

METHODS: The CORTICO-COP trial (NCT02857842) showed that an eosinophil-guided corticosteroid intervention led to approximately 60% lower accumulated corticosteroid dose for hospitalized patients with AECOPD (low-dose group) compared with 5-day standard corticosteroid treatment (high-dose group). We compared the levels of BTMs C-terminal telopeptide of type 1 collagen (CTX) and procollagen type 1 N-terminal propeptide (P1NP) in 318 participants during AECOPD and at 1- and 3-month follow-up visits.

RESULTS: CTX decreased and P1NP increased significantly over time in both treatment groups. There were no significant differences between the groups at 1- or 3-months follow-up for P1NP. A significant drop in CTX was seen at 3 months (down Δ24% from the baseline, p = 0.017) for the high dose group.

CONCLUSION: Short-term, high-dose systemic corticosteroid treatment caused a rapid suppression of biomarkers of bone resorption. Corticosteroids did not suppress biomarkers of bone formation, regardless of patients receiving low or high doses of corticosteroids. This therapy was, therefore, harmless in terms of bone safety, in our prospective series of COPD patients.

TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02857842 . Submitted August 2nd, 2016.

OriginalsprogEngelsk
Artikelnummer263
TidsskriftRespiratory Research
Vol/bind21
Udgave nummer1
Sider (fra-til)263
ISSN1465-9921
DOI
StatusUdgivet - 12 okt. 2020

ID: 61030158