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Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study

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Shanbhogue, VV, Støving, RK, Frederiksen, KH, Hanson, S, Brixen, K, Gram, J, Jørgensen, NR & Hansen, S 2017, 'Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study', European Journal of Endocrinology, bind 176, nr. 6, s. 685-693. https://doi.org/10.1530/EJE-17-0014

APA

Shanbhogue, V. V., Støving, R. K., Frederiksen, K. H., Hanson, S., Brixen, K., Gram, J., Jørgensen, N. R., & Hansen, S. (2017). Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study. European Journal of Endocrinology, 176(6), 685-693. https://doi.org/10.1530/EJE-17-0014

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Author

Shanbhogue, Vikram V ; Støving, René Klinkby ; Frederiksen, Katrine Hartmund ; Hanson, Stine ; Brixen, Kim ; Gram, Jeppe ; Jørgensen, Niklas Rye ; Hansen, Stinus. / Bone structural changes after gastric bypass surgery evaluated by HR-pQCT : a two-year longitudinal study. I: European Journal of Endocrinology. 2017 ; Bind 176, Nr. 6. s. 685-693.

Bibtex

@article{2d576a59552e48919d58a1adfa975131,
title = "Bone structural changes after gastric bypass surgery evaluated by HR-pQCT: a two-year longitudinal study",
abstract = "OBJECTIVE, DESIGN AND METHODS: Roux-en-Y gastric bypass (RYGB) has proved successful in attaining sustained weight loss but may lead to metabolic bone disease. To assess impact on bone mass and structure, we measured a real bone mineral density at the hip and spine by dual-energy X-ray absorptiometry, and volumetric BMD (vBMD) and bone microarchitecture at the distal radius and tibia by high-resolution peripheral quantitative CT in 25 morbidly obese subjects (15 females, 10 males) at 0, 12 and 24 months after RYGB. Bone turnover markers (BTMs), calciotropic and gut hormones and adipokines were measured at the same time points.RESULTS: After a 24.1% mean weight loss from baseline to month 12 (P < 0.001), body weight plateaued from month 12 to 24 (-0.9%, P = 0.50). However, cortical and trabecular vBMD and microarchitecture deteriorated through the 24 months, such that there was a 5 and 7% reduction in estimated bone strength at the radius and tibia respectively (both P < 0.001). The declines observed in the first 12 months were matched or exceeded by declines in the 12- to 24-month period. While a significant increase in BTMs and decrease in leptin and insulin were seen at 24 months, these changes were maximal at month 12 and stabilized from month 12 to 24.CONCLUSIONS: Despite weight stabilization and maintenance of metabolic parameters, bone loss and deterioration in bone strength continued and were substantial in the second year. The clinical importance of these changes in terms of increased risk of developing osteoporosis and fragility fractures remain an important concern.",
keywords = "Absorptiometry, Photon, Adiponectin, Adult, Bone Density, Bone Diseases, Metabolic, Bone Remodeling, Collagen Type I, Female, Follicle Stimulating Hormone, Gastric Bypass, Hip Joint, Humans, Insulin, Leptin, Longitudinal Studies, Lumbar Vertebrae, Luteinizing Hormone, Male, Middle Aged, Obesity, Morbid, Osteoporosis, Parathyroid Hormone, Peptide Fragments, Peptides, Postoperative Complications, Procollagen, Radius, Tibia, Tomography, X-Ray Computed, Vitamin D, Weight Loss, Journal Article",
author = "Shanbhogue, {Vikram V} and St{\o}ving, {Ren{\'e} Klinkby} and Frederiksen, {Katrine Hartmund} and Stine Hanson and Kim Brixen and Jeppe Gram and J{\o}rgensen, {Niklas Rye} and Stinus Hansen",
note = "{\textcopyright} 2017 The authors.",
year = "2017",
month = jun,
doi = "10.1530/EJE-17-0014",
language = "English",
volume = "176",
pages = "685--693",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Bone structural changes after gastric bypass surgery evaluated by HR-pQCT

T2 - a two-year longitudinal study

AU - Shanbhogue, Vikram V

AU - Støving, René Klinkby

AU - Frederiksen, Katrine Hartmund

AU - Hanson, Stine

AU - Brixen, Kim

AU - Gram, Jeppe

AU - Jørgensen, Niklas Rye

AU - Hansen, Stinus

N1 - © 2017 The authors.

PY - 2017/6

Y1 - 2017/6

N2 - OBJECTIVE, DESIGN AND METHODS: Roux-en-Y gastric bypass (RYGB) has proved successful in attaining sustained weight loss but may lead to metabolic bone disease. To assess impact on bone mass and structure, we measured a real bone mineral density at the hip and spine by dual-energy X-ray absorptiometry, and volumetric BMD (vBMD) and bone microarchitecture at the distal radius and tibia by high-resolution peripheral quantitative CT in 25 morbidly obese subjects (15 females, 10 males) at 0, 12 and 24 months after RYGB. Bone turnover markers (BTMs), calciotropic and gut hormones and adipokines were measured at the same time points.RESULTS: After a 24.1% mean weight loss from baseline to month 12 (P < 0.001), body weight plateaued from month 12 to 24 (-0.9%, P = 0.50). However, cortical and trabecular vBMD and microarchitecture deteriorated through the 24 months, such that there was a 5 and 7% reduction in estimated bone strength at the radius and tibia respectively (both P < 0.001). The declines observed in the first 12 months were matched or exceeded by declines in the 12- to 24-month period. While a significant increase in BTMs and decrease in leptin and insulin were seen at 24 months, these changes were maximal at month 12 and stabilized from month 12 to 24.CONCLUSIONS: Despite weight stabilization and maintenance of metabolic parameters, bone loss and deterioration in bone strength continued and were substantial in the second year. The clinical importance of these changes in terms of increased risk of developing osteoporosis and fragility fractures remain an important concern.

AB - OBJECTIVE, DESIGN AND METHODS: Roux-en-Y gastric bypass (RYGB) has proved successful in attaining sustained weight loss but may lead to metabolic bone disease. To assess impact on bone mass and structure, we measured a real bone mineral density at the hip and spine by dual-energy X-ray absorptiometry, and volumetric BMD (vBMD) and bone microarchitecture at the distal radius and tibia by high-resolution peripheral quantitative CT in 25 morbidly obese subjects (15 females, 10 males) at 0, 12 and 24 months after RYGB. Bone turnover markers (BTMs), calciotropic and gut hormones and adipokines were measured at the same time points.RESULTS: After a 24.1% mean weight loss from baseline to month 12 (P < 0.001), body weight plateaued from month 12 to 24 (-0.9%, P = 0.50). However, cortical and trabecular vBMD and microarchitecture deteriorated through the 24 months, such that there was a 5 and 7% reduction in estimated bone strength at the radius and tibia respectively (both P < 0.001). The declines observed in the first 12 months were matched or exceeded by declines in the 12- to 24-month period. While a significant increase in BTMs and decrease in leptin and insulin were seen at 24 months, these changes were maximal at month 12 and stabilized from month 12 to 24.CONCLUSIONS: Despite weight stabilization and maintenance of metabolic parameters, bone loss and deterioration in bone strength continued and were substantial in the second year. The clinical importance of these changes in terms of increased risk of developing osteoporosis and fragility fractures remain an important concern.

KW - Absorptiometry, Photon

KW - Adiponectin

KW - Adult

KW - Bone Density

KW - Bone Diseases, Metabolic

KW - Bone Remodeling

KW - Collagen Type I

KW - Female

KW - Follicle Stimulating Hormone

KW - Gastric Bypass

KW - Hip Joint

KW - Humans

KW - Insulin

KW - Leptin

KW - Longitudinal Studies

KW - Lumbar Vertebrae

KW - Luteinizing Hormone

KW - Male

KW - Middle Aged

KW - Obesity, Morbid

KW - Osteoporosis

KW - Parathyroid Hormone

KW - Peptide Fragments

KW - Peptides

KW - Postoperative Complications

KW - Procollagen

KW - Radius

KW - Tibia

KW - Tomography, X-Ray Computed

KW - Vitamin D

KW - Weight Loss

KW - Journal Article

U2 - 10.1530/EJE-17-0014

DO - 10.1530/EJE-17-0014

M3 - Journal article

C2 - 28289103

VL - 176

SP - 685

EP - 693

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 6

ER -

ID: 52120666