Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Biomarkers for iron metabolism among patients hospitalized with community-acquired pneumonia caused by infection with SARS-CoV-2, bacteria, and influenza

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Harvard

APA

CBE

MLA

Vancouver

Author

Bibtex

@article{241504f6bdeb440e89b0992afcfb4b06,
title = "Biomarkers for iron metabolism among patients hospitalized with community-acquired pneumonia caused by infection with SARS-CoV-2, bacteria, and influenza",
abstract = "Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP caused by bacteria or influenza virus in hospitalized patients. A cross-sectional study of 164 patients from the Surviving Pneumonia Cohort recruited between January 8, 2019 and May 26, 2020. Blood samples were collected at admission and analyzed for levels of C-reactive protein (CRP), ferritin, soluble transferrin receptor, erythroferrone, and hepcidin. Median (IQR) hepcidin was higher in SARS-CoV-2 with 143.8 (100.7-180.7) ng/mL compared with bacterial and influenza infection with 78.8 (40.1-125.4) and 53.5 (25.2-125.8) ng/mL, respectively. The median ferritin level was more than 2-fold higher in patients with SARS-CoV-2 compared with the other etiologies (p < 0.001). Patients with SARS-CoV-2 had lower levels of erythroferrone and CRP compared with those infected with bacteria. Higher levels of hepcidin and lower levels of erythroferrone despite lower CRP levels among patients with SARS-CoV-2 compared with those infected with bacteria indicate alterations in iron metabolism in patients with SARS-CoV-2 infection.",
keywords = "Biomarkers/blood, C-Reactive Protein/metabolism, COVID-19/complications, Community-Acquired Infections/blood, Cross-Sectional Studies, Ferritins, Hepcidins/metabolism, Humans, Influenza, Human/complications, Iron/metabolism, Pneumonia, Bacterial/blood, Pneumonia, Viral/blood, SARS-CoV-2, ferritin, hepcidin, community-acquired pneumonia, COVID-19, iron metabolism, erythroferrone",
author = "Hegelund, {Maria Hein} and Andreas Glenth{\o}j and Ryrs{\o}, {Camilla Koch} and Christian Ritz and Dungu, {Arnold Matovu} and Adin Sejdic and List, {Karoline Cecilie Knudsen} and Rikke Krogh-Madsen and Birgitte Lindegaard and Kurtzhals, {J{\o}rgen Anders Lindholm} and Daniel Faurholt-Jepsen",
note = "This article is protected by copyright. All rights reserved.",
year = "2022",
month = sep,
doi = "10.1111/apm.13259",
language = "English",
volume = "130",
pages = "590--596",
journal = "APMIS - Journal of Pathology, Microbiology and Immunology",
issn = "0903-4641",
publisher = "Wiley Online",
number = "9",

}

RIS

TY - JOUR

T1 - Biomarkers for iron metabolism among patients hospitalized with community-acquired pneumonia caused by infection with SARS-CoV-2, bacteria, and influenza

AU - Hegelund, Maria Hein

AU - Glenthøj, Andreas

AU - Ryrsø, Camilla Koch

AU - Ritz, Christian

AU - Dungu, Arnold Matovu

AU - Sejdic, Adin

AU - List, Karoline Cecilie Knudsen

AU - Krogh-Madsen, Rikke

AU - Lindegaard, Birgitte

AU - Kurtzhals, Jørgen Anders Lindholm

AU - Faurholt-Jepsen, Daniel

N1 - This article is protected by copyright. All rights reserved.

PY - 2022/9

Y1 - 2022/9

N2 - Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP caused by bacteria or influenza virus in hospitalized patients. A cross-sectional study of 164 patients from the Surviving Pneumonia Cohort recruited between January 8, 2019 and May 26, 2020. Blood samples were collected at admission and analyzed for levels of C-reactive protein (CRP), ferritin, soluble transferrin receptor, erythroferrone, and hepcidin. Median (IQR) hepcidin was higher in SARS-CoV-2 with 143.8 (100.7-180.7) ng/mL compared with bacterial and influenza infection with 78.8 (40.1-125.4) and 53.5 (25.2-125.8) ng/mL, respectively. The median ferritin level was more than 2-fold higher in patients with SARS-CoV-2 compared with the other etiologies (p < 0.001). Patients with SARS-CoV-2 had lower levels of erythroferrone and CRP compared with those infected with bacteria. Higher levels of hepcidin and lower levels of erythroferrone despite lower CRP levels among patients with SARS-CoV-2 compared with those infected with bacteria indicate alterations in iron metabolism in patients with SARS-CoV-2 infection.

AB - Ferritin, the central iron storage protein, has attracted attention as a biomarker of severe COVID-19. Few studies have investigated regulators of iron metabolism in the context of COVID-19. The aim was to evaluate biomarkers for iron metabolism in the acute phase response to community-acquired pneumonia (CAP) caused by SARS-CoV-2 compared with CAP caused by bacteria or influenza virus in hospitalized patients. A cross-sectional study of 164 patients from the Surviving Pneumonia Cohort recruited between January 8, 2019 and May 26, 2020. Blood samples were collected at admission and analyzed for levels of C-reactive protein (CRP), ferritin, soluble transferrin receptor, erythroferrone, and hepcidin. Median (IQR) hepcidin was higher in SARS-CoV-2 with 143.8 (100.7-180.7) ng/mL compared with bacterial and influenza infection with 78.8 (40.1-125.4) and 53.5 (25.2-125.8) ng/mL, respectively. The median ferritin level was more than 2-fold higher in patients with SARS-CoV-2 compared with the other etiologies (p < 0.001). Patients with SARS-CoV-2 had lower levels of erythroferrone and CRP compared with those infected with bacteria. Higher levels of hepcidin and lower levels of erythroferrone despite lower CRP levels among patients with SARS-CoV-2 compared with those infected with bacteria indicate alterations in iron metabolism in patients with SARS-CoV-2 infection.

KW - Biomarkers/blood

KW - C-Reactive Protein/metabolism

KW - COVID-19/complications

KW - Community-Acquired Infections/blood

KW - Cross-Sectional Studies

KW - Ferritins

KW - Hepcidins/metabolism

KW - Humans

KW - Influenza, Human/complications

KW - Iron/metabolism

KW - Pneumonia, Bacterial/blood

KW - Pneumonia, Viral/blood

KW - SARS-CoV-2

KW - ferritin

KW - hepcidin

KW - community-acquired pneumonia

KW - COVID-19

KW - iron metabolism

KW - erythroferrone

UR - http://www.scopus.com/inward/record.url?scp=85135058508&partnerID=8YFLogxK

U2 - 10.1111/apm.13259

DO - 10.1111/apm.13259

M3 - Journal article

C2 - 35751642

VL - 130

SP - 590

EP - 596

JO - APMIS - Journal of Pathology, Microbiology and Immunology

JF - APMIS - Journal of Pathology, Microbiology and Immunology

SN - 0903-4641

IS - 9

ER -

ID: 79005328