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Beneficial impact of intensified multifactorial intervention on risk of stroke: outcome of 21 years of follow-up in the randomised Steno-2 Study

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Gæde, Peter ; Oellgaard, Jens ; Kruuse, Christina ; Rossing, Peter ; Parving, Hans-Henrik ; Pedersen, Oluf. / Beneficial impact of intensified multifactorial intervention on risk of stroke : outcome of 21 years of follow-up in the randomised Steno-2 Study. I: Diabetologia. 2019 ; Bind 62, Nr. 9. s. 1575-1580.

Bibtex

@article{411b709d03404a03a0b7faa2089f4a14,
title = "Beneficial impact of intensified multifactorial intervention on risk of stroke: outcome of 21 years of follow-up in the randomised Steno-2 Study",
abstract = "AIMS/HYPOTHESIS: Epidemiological studies have shown that diabetes is a well-established independent but modifiable risk factor for stroke. The aim of this post hoc analysis of data from the Steno-2 Study was to examine whether multiple risk factor intervention reduced the risk for stroke in individuals with type 2 diabetes and microalbuminuria.METHODS: In the Steno-2 Study, 160 individuals with type 2 diabetes and microalbuminuria were randomised to intensified or conventional multiple risk factor intervention, targeting classical cardiovascular disease risk factors for a mean of 7.8 years, and then followed for a total mean of 21.2 years. The primary endpoint in this post hoc analysis was time to first stroke event.RESULTS: During follow-up, 30 participants experienced a total of 39 strokes. Individuals randomised to conventional therapy were more likely to experience a stroke than those in the intensive-therapy group, with 29 total strokes occurring in 21 participants (26{\%}) in the conventional-therapy group vs a total of ten strokes in nine participants (11{\%}) in the intensive-therapy group (HR 0.31 [95{\%} CI 0.14, 0.69]; p = 0.004). Also, the number of recurrent strokes was significantly reduced with intensive therapy.CONCLUSIONS/INTERPRETATION: Intensified multiple risk factor intervention in patients with type 2 diabetes and microalbuminuria reduces the risk for strokes as well as the number of recurrent cerebrovascular events.TRIAL REGISTRATION: ClinicalTrials.gov NCT00320008.",
author = "Peter G{\ae}de and Jens Oellgaard and Christina Kruuse and Peter Rossing and Hans-Henrik Parving and Oluf Pedersen",
year = "2019",
month = "9",
day = "1",
doi = "10.1007/s00125-019-4920-3",
language = "English",
volume = "62",
pages = "1575--1580",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "9",

}

RIS

TY - JOUR

T1 - Beneficial impact of intensified multifactorial intervention on risk of stroke

T2 - outcome of 21 years of follow-up in the randomised Steno-2 Study

AU - Gæde, Peter

AU - Oellgaard, Jens

AU - Kruuse, Christina

AU - Rossing, Peter

AU - Parving, Hans-Henrik

AU - Pedersen, Oluf

PY - 2019/9/1

Y1 - 2019/9/1

N2 - AIMS/HYPOTHESIS: Epidemiological studies have shown that diabetes is a well-established independent but modifiable risk factor for stroke. The aim of this post hoc analysis of data from the Steno-2 Study was to examine whether multiple risk factor intervention reduced the risk for stroke in individuals with type 2 diabetes and microalbuminuria.METHODS: In the Steno-2 Study, 160 individuals with type 2 diabetes and microalbuminuria were randomised to intensified or conventional multiple risk factor intervention, targeting classical cardiovascular disease risk factors for a mean of 7.8 years, and then followed for a total mean of 21.2 years. The primary endpoint in this post hoc analysis was time to first stroke event.RESULTS: During follow-up, 30 participants experienced a total of 39 strokes. Individuals randomised to conventional therapy were more likely to experience a stroke than those in the intensive-therapy group, with 29 total strokes occurring in 21 participants (26%) in the conventional-therapy group vs a total of ten strokes in nine participants (11%) in the intensive-therapy group (HR 0.31 [95% CI 0.14, 0.69]; p = 0.004). Also, the number of recurrent strokes was significantly reduced with intensive therapy.CONCLUSIONS/INTERPRETATION: Intensified multiple risk factor intervention in patients with type 2 diabetes and microalbuminuria reduces the risk for strokes as well as the number of recurrent cerebrovascular events.TRIAL REGISTRATION: ClinicalTrials.gov NCT00320008.

AB - AIMS/HYPOTHESIS: Epidemiological studies have shown that diabetes is a well-established independent but modifiable risk factor for stroke. The aim of this post hoc analysis of data from the Steno-2 Study was to examine whether multiple risk factor intervention reduced the risk for stroke in individuals with type 2 diabetes and microalbuminuria.METHODS: In the Steno-2 Study, 160 individuals with type 2 diabetes and microalbuminuria were randomised to intensified or conventional multiple risk factor intervention, targeting classical cardiovascular disease risk factors for a mean of 7.8 years, and then followed for a total mean of 21.2 years. The primary endpoint in this post hoc analysis was time to first stroke event.RESULTS: During follow-up, 30 participants experienced a total of 39 strokes. Individuals randomised to conventional therapy were more likely to experience a stroke than those in the intensive-therapy group, with 29 total strokes occurring in 21 participants (26%) in the conventional-therapy group vs a total of ten strokes in nine participants (11%) in the intensive-therapy group (HR 0.31 [95% CI 0.14, 0.69]; p = 0.004). Also, the number of recurrent strokes was significantly reduced with intensive therapy.CONCLUSIONS/INTERPRETATION: Intensified multiple risk factor intervention in patients with type 2 diabetes and microalbuminuria reduces the risk for strokes as well as the number of recurrent cerebrovascular events.TRIAL REGISTRATION: ClinicalTrials.gov NCT00320008.

UR - http://www.scopus.com/inward/record.url?scp=85066468046&partnerID=8YFLogxK

U2 - 10.1007/s00125-019-4920-3

DO - 10.1007/s00125-019-4920-3

M3 - Journal article

VL - 62

SP - 1575

EP - 1580

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 9

ER -

ID: 57290173