Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Bacterial invasion of the inner ear in association with pneumococcal meningitis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Natural History of Hearing Loss in Pendred Syndrome and Non-Syndromic Enlarged Vestibular Aqueduct

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The Effect of a Distributed Virtual Reality Simulation Training Program on Dissection Mastoidectomy Performance

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Neuronal Fibers and Neurotransmitter Receptor Expression in the Human Endolymphatic Sac

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Clinical Outcome of a Wide-diameter Bone-anchored Hearing Implant and a Surgical Technique With Tissue Preservation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Natural History of Hearing Loss in Pendred Syndrome and Non-Syndromic Enlarged Vestibular Aqueduct

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Language outcome in children with congenital hearing impairment: The influence of etiology

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Facial nerve schwannomas presenting with vestibular dysfunction: a case series

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The Effect of a Distributed Virtual Reality Simulation Training Program on Dissection Mastoidectomy Performance

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: To examine the pathways of bacterial invasion and subsequent spreading in the inner ear during pneumococcal meningitis.

STUDY DESIGN: A well-established adult rat model of Streptococcus pneumoniae meningitis was used.

METHODS: Thirty rats were inoculated intrathecally with S. pneumoniae serotype 1, 3 or 9 V and received no additional treatment. The rats were sacrificed when reaching terminal illness or on Day 7 and then prepared for serial sectioning and PAS-Alcian blue staining for light microscopy.

RESULTS: During the first few days after inoculation, bacteria invade the inner ear through the cochlear aqueduct, into the scala tympani of the cochlea (perilymphatic space). From here, bacteria spreads apically toward the helicotrema and subsequently basally through the scala vestibuli, toward the vestibule and the vestibular system. When the bacteria after 5 to 6 days had reached scala vestibuli of the basal turn of the cochlea, hematogenous spreading occurred to the spiral ligament and into the cochlear endolymph, subsequently to the vestibular endolymph. We found no evidence of alternative routes for bacterial invasion in the inner ear. Several internal barriers to bacterial spreading were found within the inner ear. Bacterial elimination was evidenced by engulfment by macrophages within the inner ear.

CONCLUSION: From the meninges, pneumococci invade the inner ear through the cochlear aqueduct during the first days of infection, whereas hematogenous invasion via the spiral ligament capillary bed occur at later stages. Although internal barriers exist within the inner ear, the spreading of bacteria occurs via the natural pathways of the fluid compartments. Bacterial elimination occurs by local macrophage engulfment.

OriginalsprogEngelsk
TidsskriftOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
Vol/bind35
Udgave nummer5
Sider (fra-til)e178-86
ISSN1531-7129
DOI
StatusUdgivet - jun. 2014

ID: 44332957