Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Bacterial biofilm formation inside colonic crypts may accelerate colorectal carcinogenesis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Is pseudarthrosis after spinal instrumentation caused by a chronic infection?

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. An Equine Wound Model to Study Effects of Bacterial Aggregates on Wound Healing

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Analysis of proximal bone margins in diabetic foot osteomyelitis by conventional culture, DNA sequencing and microscopy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Antimicrobial Tolerance and Metabolic Adaptations in Microbial Biofilms

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

BACKGROUND: Research in the field of relation between microbes and colorectal carcinogenesis has gained increasing interest in past years. Recently, link between microbial biofilm and carcinogenesis in colon was demonstrated by several authors indicating that biofilm not only is a key player in carcinogenesis, but also may contribute to the understanding of side-specific colon cancer-right sided colon cancer versus left sided. In this article, we briefly highlight the major findings of the research of biofilm and carcinogenesis and demonstrate our findings of colonic cancer tissue and colonic polyp examined for biofilm.

CASE PRESENTATION: Colonic cancer tissue from a patient with a right-sided colon cancer, and an adenoma tubular polyp were examined for biofilm formation by flourescens in situ hybridization. In cancer tissue we found biofilm formation on the surface epithelium but surprisingly also deep into the crypts. No biofilms were found in tubular polyp tissue.

CONCLUSIONS: To our knowledge, this is the first-time biofilm formation deep into colonic crypts are demonstrated in a patient with right-sided colon cancer. This may indicate that bacterial biofilm may have a key role in carcinogenesis.

OriginalsprogEngelsk
TidsskriftClinical and Translational Medicine
Vol/bind7
Udgave nummer1
Sider (fra-til)30
ISSN2001-1326
DOI
StatusUdgivet - 17 sep. 2018

ID: 55269155