Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Auto-inflammatory challenge of the endolymphatic sac--Cochlear damage measured by distortion product oto-acoustic emissions

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Correlation between HPV status at T and N sites of oropharyngeal squamous cell carcinomas

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Indications, risk of lower airway infection, and complications to pediatric tracheotomy: report from a tertiary referral center

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Inhibition of phosphodiesterase 3, 4, and 5 induces endolymphatic hydrops in mouse inner ear, as evaluated with repeated 9.4T MRI

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Auditory profiling and hearing-aid satisfaction in hearing-aid candidates

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The middle ear immune defense changes with age

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Labyrinthitis Ossificans: On the Mechanism of Perilabyrinthine Bone Remodeling

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Differential Gene Expression in the Otic Capsule and the Middle Ear-An Annotation of Bone-Related Signaling Genes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Bone signaling in middle ear development: a genome-wide differential expression analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Michael Larsen
  • Morten Friis
  • Charlotte Vestrup Karlsen
  • Steen Seier Poulsen
  • Søren Peter Lund
  • Klaus Qvortrup
Vis graf over relationer

CONCLUSION: Twenty-five rats were challenged by an immunologic attack of the endolymphatic sac. After 6 months, distortion product oto-acoustic emissions (DPOAE) revealed a dysfunction of the outer hair cells and immunological active cells were observed in the endolymphatic sac. This information could contribute to the understanding of Ménière's disease.

OBJECTIVES: This study investigated if an autoimmune challenge of the endolymphatic sac could affect DPOAE output measurements in rats. Also, a potential autoimmune cell infiltration of the endolymphatic sac was investigated.

METHODS: Eighteen Lewis rats were immunized with a crude endolymphatic sac extract in complete Freund's adjuvant. Seven control animals were injected with Freund's adjuvant in saline. Cochlear damage was estimated by DPOAE dynamics 3 weeks and 6 months after the immunization. Infiltrative cells in the endolymphatic sac were investigated with transmission electron microscopy.

RESULTS: The hearing assessment 6 months after immunization revealed a reduction of the DPOAE, on the full range of frequencies (2-63 kHz) in an average of the mean, of 2 dB ± 1.1 in the immunized group compared to the controls (p < 0.05). The same test showed a 2.5 dB decrease from 2 to 5 kHz (p < 0.01). Immunological active cells were observed in the endolymphatic sac in most of the immunized rats.

OriginalsprogEngelsk
TidsskriftActa Oto-Laryngologica
Vol/bind135
Udgave nummer8
Sider (fra-til)758-64
Antal sider7
ISSN0001-6489
DOI
StatusUdgivet - aug. 2015

ID: 46013829