Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Astaxanthin from Shrimp Cephalothorax Stimulates the Immune Response by Enhancing IFN-γ, IL-10, and IL-2 Secretion in Splenocytes of Helicobacter Pylori-Infected Mice

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Targeting BKCa Channels in Migraine: Rationale and Perspectives

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Pathophysiological Mechanisms in Migraine and the Identification of New Therapeutic Targets

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Assessment of Opicinumab in Acute Optic Neuritis Using Multifocal Visual Evoked Potential

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Monoclonal Antibodies for Relapsing Multiple Sclerosis: A Review of Recently Marketed and Late-Stage Agents

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  5. Pharmacokinetic Variability of Drugs Used for Prophylactic Treatment of Migraine

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Molecular characterization of Danish ESBL/AmpC-producing Klebsiella pneumoniae from bloodstream infections, 2018

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Clinical Manifestations of the Epsilonproteobacteria (Helicobacter pylori)

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiUndervisningpeer review

Vis graf over relationer

Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection includes gastric inflammation, which is characterized by a sustained recruitment of T-helper (Th) cells to the site of infection and distinct patterns of cytokine production. Adequate nutritional status, especially frequent consumption of dietary antioxidants, appears to protect against infection with H. pylori. The aim of the present study was to investigate whether astaxanthin (AXT) from shrimp cephalothorax may modulate cytokine release of splenocytes in H. pylori-infected mice (n = 60). Six- to eight-week-old female mice were divided into three groups (n = 20 per group) to receive a daily oral dose of 10 or 40 mg of AXT for six weeks. After six weeks, a trend toward interferon gamma (IFN-γ) upregulation was found (40 mg; p < 0.05) and a significant dose-dependent increase of interleukin 2 (IL-2) and IL-10 (both p < 0.05) was observed. These results suggest that AXT induces higher levels of IL-2 and a shift to a balanced Th1/Th2 response by increasing IFN-γ and augmenting IL-10. We concluded that AXT may influence the pattern of cytokines during H. pylori infection.

OriginalsprogEngelsk
TidsskriftCNS Drugs
Vol/bind17
Udgave nummer7
ISSN1172-7047
DOI
StatusUdgivet - 26 jun. 2019

ID: 59012754