Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Associations of genetic determinants of serum vitamin B12 and folate concentrations with hay fever and asthma: a Mendelian randomization meta-analysis

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Copeptin, a surrogate marker for arginine vasopressin secretion, is positively associated with glucagon

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Dysregulation of a long noncoding RNA reduces leptin leading to a leptin-responsive form of obesity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Sex-Specific Epidemiology of Heart Failure Risk and Mortality in Europe: Results From the BiomarCaRE Consortium

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Association of alcohol consumption with allergic disease and asthma: a multi-centre Mendelian randomization analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Tea Skaaby
  • Amy E Taylor
  • Rikke K Jacobsen
  • Line T Møllehave
  • Nele Friedrich
  • Betina H Thuesen
  • Daniel Mønsted Shabanzadeh
  • Lavinia Paternoster
  • Uwe Völker
  • Matthias Nauck
  • Henry Völzke
  • Marcus Munafò
  • Torben Hansen
  • Oluf Pedersen
  • Torben Jørgensen
  • Niels Grarup
  • Allan Linneberg
Vis graf over relationer

BACKGROUND/OBJECTIVES: Studies of the effect of vitamin B12 and folate on the risk of asthma and hay fever have shown inconsistent results that may be biased by reverse causation and confounding. We used a Mendelian randomization approach to examine a potential causal effect of vitamin B12 and folate on hay fever, asthma, and selected biomarkers of allergy by using 11 vitamin B12-associated single-nucleotide polymorphisms (SNPs) and 2 folate-associated SNPs as unconfounded markers.

SUBJECTS/METHODS: We included 162,736 participants from 9 population-based studies including the UK Biobank. Results were combined in instrumental variable and meta-analyses and effects expressed as odds ratios (ORs) or estimates with 95% confidence interval (CI).

RESULTS: Using genetic proxies for B12 and folate, instrumental variable analyses did not show evidence for associations between serum B12 and hay fever: OR = 1.02 (95% CI: 0.98, 1.05), asthma: OR = 0.99 (95% CI: 0.95, 1.04), allergic sensitization: OR = 1.02 (95% CI: 0.74, 1.40), or change in serum IgE: 10.0% (95% CI: -9.6%, 29.6%) per 100 pg/ml B12. Similarly, there was no evidence for association between serum folate and hay fever: OR = 0.74 (95% CI: 0.45, 1.21), asthma: OR = 0.80 (95% CI: 0.43, 1.49), or allergic sensitization: OR = 1.92 (95% CI: 0.11, 33.45), but there was a statistically significant association with change in serum IgE: 2.0% (95% CI: 0.43%, 3.58%) per 0.1 ng/ml serum folate.

CONCLUSIONS: Our results did not support the hypothesis that levels of vitamin B12 and folate are causally related to hay fever, asthma, or biomarkers of allergy, but we found evidence of a positive association between serum folate and serum total IgE.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Nutrition
Vol/bind72
Udgave nummer2
Sider (fra-til)264-271
ISSN0954-3007
DOI
StatusUdgivet - 2018

ID: 52362100