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Association of Immunoglobulin G3 Hinge Region Length Polymorphism With Cerebral Malaria in Ghanaian Children

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  • Eric Kyei-Baafour
  • Kwadwo A Kusi
  • Fareed K N Arthur
  • Tracy Sarkodie-Addo
  • Michael Theisen
  • Daniel Dodoo
  • Bright Adu
Vis graf over relationer

Cerebral malaria (CM) may cause death or long-term neurological damage in children, and several host genetic risk factors have been reported. Malaria-specific immunoglobulin (Ig) G3 antibodies are crucial to human immune response against malaria. The hinge region of IgG3 exhibits length polymorphism (with long [L], medium [M], and short [S] alleles), which may influence its functionality. We studied IgG3 hinge region length polymorphisms in 136 Ghanaian children with malaria. Using logistic regression models, we found that children with the recessive MM allotype encoding medium IgG3 hinge region length had an increased risk of CM (adjusted odds ratio, 6.67 [95% confidence interval,1.30-34.32]; P=.004) . This has implications for future epidemiological studies on CM.

TidsskriftThe Journal of infectious diseases
Udgave nummer10
Sider (fra-til)1786-1790
Antal sider5
StatusUdgivet - 16 maj 2022

Bibliografisk note

© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail:

ID: 79444625