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Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

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Harvard

Patel, VL, Busch, EL, Friebel, TM, Cronin, A, Leslie, G, McGuffog, L, Adlard, J, Agata, S, Agnarsson, BA, Ahmed, M, Aittomäki, K, Alducci, E, Andrulis, IL, Arason, A, Arnold, N, Artioli, G, Arver, B, Auber, B, Azzollini, J, Balmaña, J, Barkardottir, RB, Barnes, DR, Barroso, A, Barrowdale, D, Belotti, M, Benitez, J, Bertelsen, B, Blok, MJ, Bodrogi, I, Bonadona, V, Bonanni, B, Bondavalli, D, Boonen, SE, Borde, J, Borg, A, Bradbury, AR, Brady, A, Brewer, C, Brunet, J, Buecher, B, Buys, SS, Cabezas-Camarero, S, Caldés, T, Caliebe, A, Caligo, MA, Calvello, M, Campbell, IG, Carnevali, I, Carrasco, E, Chan, TL, Chu, ATW, Chung, WK, Claes, KBM, Collaborators, GS, Collaborators, E, Cook, J, Cortesi, L, Couch, FJ, Daly, MB, Damante, G, Darder, E, Davidson, R, de la Hoya, M, Della Puppa, L, Dennis, J, Díez, O, Ding, YC, Ditsch, N, Domchek, SM, Donaldson, A, Dworniczak, B, Easton, DF, Eccles, DM, Eeles, RA, Ehrencrona, H, Ejlertsen, B, Engel, C, Evans, DG, Faivre, L, Faust, U, Feliubadaló, L, Foretova, L, Fostira, F, Fountzilas, G, Frost, D, García-Barberán, V, Garre, P, Gauthier-Villars, M, Géczi, L, Gehrig, A, Gerdes, A-M, Gesta, P, Giannini, G, Glendon, G, Godwin, AK, Goldgar, DE, Greene, MH, Gutierrez-Barrera, AM, Hahnen, E, Hamann, U, Hauke, J, Herold, N, Hogervorst, FBL, Honisch, E, Hopper, JL, Hulick, PJ, Investigators, KC, Investigators, H, Izatt, L, Jager, A, James, P, Janavicius, R, Jensen, UB, Jensen, TD, Johannsson, OT, John, EM, Joseph, V, Kang, E, Kast, K, Kiiski, JI, Kim, S-W, Kim, Z, Ko, K-P, Konstantopoulou, I, Kramer, G, Krogh, L, Kruse, TA, Kwong, A, Larsen, M, Lasset, C, Lautrup, C, Lázaro, C, Lee, J, Lee, JW, Lee, MH, Lemke, J, Lesueur, F, Liljegren, A, Lindblom, A, Llovet, P, Lopez-Fernández, A, Lopez-Perolio, I, Lorca, V, Loud, JT, Ma, ESK, Mai, PL, Manoukian, S, Mari, V, Martin, L, Matricardi, L, Mebirouk, N, Medici, V, Meijers-Heijboer, HEJ, Meindl, A, Mensenkamp, AR, Miller, C, Molina Gomes, D, Montagna, M, Mooij, TM, Moserle, L, Mouret-Fourme, E, Mulligan, AM, Nathanson, KL, Navratilova, M, Nevanlinna, H, Niederacher, D, Cilius Nielsen, FC, Nikitina-Zake, L, Offit, K, Olah, E, Olopade, OI, Ong, K-R, Osorio, A, Ott, C-E, Palli, D, Park, SK, Parsons, MT, Pedersen, IS, Peissel, B, Peixoto, A, Pérez-Segura, P, Peterlongo, P, Høgh Petersen, A, Porteous, ME, Pujana, MA, Radice, P, Ramser, J, Rantala, J, Rashid, MU, Rhiem, K, Rizzolo, P, Robson, ME, Rookus, MA, Rossing, CM, Ruddy, KJ, Santos, C, Saule, C, Scarpitta, R, Schmutzler, RK, Schuster, H, Senter, L, Seynaeve, CM, Shah, PD, Sharma, P, Shin, VY, Silvestri, V, Simard, J, Singer, CF, Skytte, A-B, Snape, K, Solano, AR, Soucy, P, Southey, MC, Spurdle, AB, Steele, L, Steinemann, D, Stoppa-Lyonnet, D, Stradella, A, Sunde, L, Sutter, C, Tan, YY, Teixeira, MR, Teo, SH, Thomassen, M, Tibiletti, MG, Tischkowitz, M, Tognazzo, S, Toland, AE, Tommasi, S, Torres, D, Toss, A, Trainer, AH, Tung, N, van Asperen, CJ, van der Baan, FH, van der Kolk, LE, van der Luijt, RB, van Hest, LP, Varesco, L, Varon-Mateeva, R, Viel, A, Vierstraete, J, Villa, R, von Wachenfeldt, A, Wagner, P, Wang-Gohrke, S, Wappenschmidt, B, Weitzel, JN, Wieme, G, Yadav, S, Yannoukakos, D, Yoon, S-Y, Zanzottera, C, Zorn, KK, D'Amico, AV, Freedman, ML, Pomerantz, MM, Chenevix-Trench, G, Antoniou, AC, Neuhausen, SL, Ottini, L, Nielsen, HR & Rebbeck, TR 2020, 'Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness' Cancer Research, bind 80, nr. 3, s. 624-638. https://doi.org/10.1158/0008-5472.CAN-19-1840

APA

Patel, V. L., Busch, E. L., Friebel, T. M., Cronin, A., Leslie, G., McGuffog, L., ... Rebbeck, T. R. (2020). Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness. Cancer Research, 80(3), 624-638. https://doi.org/10.1158/0008-5472.CAN-19-1840

CBE

Patel VL, Busch EL, Friebel TM, Cronin A, Leslie G, McGuffog L, Adlard J, Agata S, Agnarsson BA, Ahmed M, Aittomäki K, Alducci E, Andrulis IL, Arason A, Arnold N, Artioli G, Arver B, Auber B, Azzollini J, Balmaña J, Barkardottir RB, Barnes DR, Barroso A, Barrowdale D, Belotti M, Benitez J, Bertelsen B, Blok MJ, Bodrogi I, Bonadona V, Bonanni B, Bondavalli D, Boonen SE, Borde J, Borg A, Bradbury AR, Brady A, Brewer C, Brunet J, Buecher B, Buys SS, Cabezas-Camarero S, Caldés T, Caliebe A, Caligo MA, Calvello M, Campbell IG, Carnevali I, Carrasco E, Chan TL, Chu ATW, Chung WK, Claes KBM, Collaborators GS, Collaborators E, Cook J, Cortesi L, Couch FJ, Daly MB, Damante G, Darder E, Davidson R, de la Hoya M, Della Puppa L, Dennis J, Díez O, Ding YC, Ditsch N, Domchek SM, Donaldson A, Dworniczak B, Easton DF, Eccles DM, Eeles RA, Ehrencrona H, Ejlertsen B, Engel C, Evans DG, Faivre L, Faust U, Feliubadaló L, Foretova L, Fostira F, Fountzilas G, Frost D, García-Barberán V, Garre P, Gauthier-Villars M, Géczi L, Gehrig A, Gerdes A-M, Gesta P, Giannini G, Glendon G, Godwin AK, Goldgar DE, Greene MH, Gutierrez-Barrera AM, Hahnen E, Hamann U, Hauke J, Herold N, Hogervorst FBL, Honisch E, Hopper JL, Hulick PJ, Investigators KC, Investigators H, Izatt L, Jager A, James P, Janavicius R, Jensen UB, Jensen TD, Johannsson OT, John EM, Joseph V, Kang E, Kast K, Kiiski JI, Kim S-W, Kim Z, Ko K-P, Konstantopoulou I, Kramer G, Krogh L, Kruse TA, Kwong A, Larsen M, Lasset C, Lautrup C, Lázaro C, Lee J, Lee JW, Lee MH, Lemke J, Lesueur F, Liljegren A, Lindblom A, Llovet P, Lopez-Fernández A, Lopez-Perolio I, Lorca V, Loud JT, Ma ESK, Mai PL, Manoukian S, Mari V, Martin L, Matricardi L, Mebirouk N, Medici V, Meijers-Heijboer HEJ, Meindl A, Mensenkamp AR, Miller C, Molina Gomes D, Montagna M, Mooij TM, Moserle L, Mouret-Fourme E, Mulligan AM, Nathanson KL, Navratilova M, Nevanlinna H, Niederacher D, Cilius Nielsen FC, Nikitina-Zake L, Offit K, Olah E, Olopade OI, Ong K-R, Osorio A, Ott C-E, Palli D, Park SK, Parsons MT, Pedersen IS, Peissel B, Peixoto A, Pérez-Segura P, Peterlongo P, Høgh Petersen A, Porteous ME, Pujana MA, Radice P, Ramser J, Rantala J, Rashid MU, Rhiem K, Rizzolo P, Robson ME, Rookus MA, Rossing CM, Ruddy KJ, Santos C, Saule C, Scarpitta R, Schmutzler RK, Schuster H, Senter L, Seynaeve CM, Shah PD, Sharma P, Shin VY, Silvestri V, Simard J, Singer CF, Skytte A-B, Snape K, Solano AR, Soucy P, Southey MC, Spurdle AB, Steele L, Steinemann D, Stoppa-Lyonnet D, Stradella A, Sunde L, Sutter C, Tan YY, Teixeira MR, Teo SH, Thomassen M, Tibiletti MG, Tischkowitz M, Tognazzo S, Toland AE, Tommasi S, Torres D, Toss A, Trainer AH, Tung N, van Asperen CJ, van der Baan FH, van der Kolk LE, van der Luijt RB, van Hest LP, Varesco L, Varon-Mateeva R, Viel A, Vierstraete J, Villa R, von Wachenfeldt A, Wagner P, Wang-Gohrke S, Wappenschmidt B, Weitzel JN, Wieme G, Yadav S, Yannoukakos D, Yoon S-Y, Zanzottera C, Zorn KK, D'Amico AV, Freedman ML, Pomerantz MM, Chenevix-Trench G, Antoniou AC, Neuhausen SL, Ottini L, Nielsen HR, Rebbeck TR. 2020. Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness. Cancer Research. 80(3):624-638. https://doi.org/10.1158/0008-5472.CAN-19-1840

MLA

Vancouver

Author

Patel, Vivek L ; Busch, Evan L ; Friebel, Tara M ; Cronin, Angel ; Leslie, Goska ; McGuffog, Lesley ; Adlard, Julian ; Agata, Simona ; Agnarsson, Bjarni A ; Ahmed, Munaza ; Aittomäki, Kristiina ; Alducci, Elisa ; Andrulis, Irene L ; Arason, Adalgeir ; Arnold, Norbert ; Artioli, Grazia ; Arver, Brita ; Auber, Bernd ; Azzollini, Jacopo ; Balmaña, Judith ; Barkardottir, Rosa B ; Barnes, Daniel R ; Barroso, Alicia ; Barrowdale, Daniel ; Belotti, Muriel ; Benitez, Javier ; Bertelsen, Brigitte ; Blok, Marinus J ; Bodrogi, Istvan ; Bonadona, Valérie ; Bonanni, Bernardo ; Bondavalli, Davide ; Boonen, Susanne E ; Borde, Julika ; Borg, Ake ; Bradbury, Angela R ; Brady, Angela ; Brewer, Carole ; Brunet, Joan ; Buecher, Bruno ; Buys, Saundra S ; Cabezas-Camarero, Santiago ; Caldés, Trinidad ; Caliebe, Almuth ; Caligo, Maria A ; Calvello, Mariarosaria ; Campbell, Ian G ; Carnevali, Ileana ; Carrasco, Estela ; Chan, Tsun L ; Chu, Annie T W ; Chung, Wendy K ; Claes, Kathleen B M ; Collaborators, Gemo Study ; Collaborators, Embrace ; Cook, Jackie ; Cortesi, Laura ; Couch, Fergus J ; Daly, Mary B ; Damante, Giuseppe ; Darder, Esther ; Davidson, Rosemarie ; de la Hoya, Miguel ; Della Puppa, Lara ; Dennis, Joe ; Díez, Orland ; Ding, Yuan Chun ; Ditsch, Nina ; Domchek, Susan M ; Donaldson, Alan ; Dworniczak, Bernd ; Easton, Douglas F ; Eccles, Diana M ; Eeles, Rosalind A ; Ehrencrona, Hans ; Ejlertsen, Bent ; Engel, Christoph ; Evans, D Gareth ; Faivre, Laurence ; Faust, Ulrike ; Feliubadaló, Lídia ; Foretova, Lenka ; Fostira, Florentia ; Fountzilas, George ; Frost, Debra ; García-Barberán, Vanesa ; Garre, Pilar ; Gauthier-Villars, Marion ; Géczi, Lajos ; Gehrig, Andrea ; Gerdes, Anne-Marie ; Gesta, Paul ; Giannini, Giuseppe ; Glendon, Gord ; Godwin, Andrew K ; Goldgar, David E ; Greene, Mark H ; Gutierrez-Barrera, Angelica M ; Hahnen, Eric ; Hamann, Ute ; Hauke, Jan ; Herold, Natalie ; Hogervorst, Frans B L ; Honisch, Ellen ; Hopper, John L ; Hulick, Peter J ; Investigators, kConFab ; Investigators, Hebon ; Izatt, Louise ; Jager, Agnes ; James, Paul ; Janavicius, Ramunas ; Jensen, Uffe Birk ; Jensen, Thomas Dyrso ; Johannsson, Oskar Th ; John, Esther M ; Joseph, Vijai ; Kang, Eunyoung ; Kast, Karin ; Kiiski, Johanna I ; Kim, Sung-Won ; Kim, Zisun ; Ko, Kwang-Pil ; Konstantopoulou, Irene ; Kramer, Gero ; Krogh, Lotte ; Kruse, Torben A ; Kwong, Ava ; Larsen, Mirjam ; Lasset, Christine ; Lautrup, Charlotte ; Lázaro, Conxi ; Lee, Jihyoun ; Lee, Jong Won ; Lee, Min Hyuk ; Lemke, Johannes ; Lesueur, Fabienne ; Liljegren, Annelie ; Lindblom, Annika ; Llovet, Patricia ; Lopez-Fernández, Adria ; Lopez-Perolio, Irene ; Lorca, Victor ; Loud, Jennifer T ; Ma, Edmond S K ; Mai, Phuong L ; Manoukian, Siranoush ; Mari, Veronique ; Martin, Lynn ; Matricardi, Laura ; Mebirouk, Noura ; Medici, Veronica ; Meijers-Heijboer, Hanne E J ; Meindl, Alfons ; Mensenkamp, Arjen R ; Miller, Clare ; Molina Gomes, Denise ; Montagna, Marco ; Mooij, Thea M ; Moserle, Lidia ; Mouret-Fourme, Emmanuelle ; Mulligan, Anna Marie ; Nathanson, Katherine L ; Navratilova, Marie ; Nevanlinna, Heli ; Niederacher, Dieter ; Cilius Nielsen, Finn C ; Nikitina-Zake, Liene ; Offit, Kenneth ; Olah, Edith ; Olopade, Olufunmilayo I ; Ong, Kai-Ren ; Osorio, Ana ; Ott, Claus-Eric ; Palli, Domenico ; Park, Sue K ; Parsons, Michael T ; Pedersen, Inge Sokilde ; Peissel, Bernard ; Peixoto, Ana ; Pérez-Segura, Pedro ; Peterlongo, Paolo ; Høgh Petersen, Annabeth ; Porteous, Mary E ; Pujana, Miguel Angel ; Radice, Paolo ; Ramser, Juliane ; Rantala, Johanna ; Rashid, Muhammad U ; Rhiem, Kerstin ; Rizzolo, Piera ; Robson, Mark E ; Rookus, Matti A ; Rossing, Caroline Maria ; Ruddy, Kathryn J ; Santos, Catarina ; Saule, Claire ; Scarpitta, Rosa ; Schmutzler, Rita K ; Schuster, Hélène ; Senter, Leigha ; Seynaeve, Caroline M ; Shah, Payal D ; Sharma, Priyanka ; Shin, Vivian Y ; Silvestri, Valentina ; Simard, Jacques ; Singer, Christian F ; Skytte, Anne-Bine ; Snape, Katie ; Solano, Angela R ; Soucy, Penny ; Southey, Melissa C ; Spurdle, Amanda B ; Steele, Linda ; Steinemann, Doris ; Stoppa-Lyonnet, Dominique ; Stradella, Agostina ; Sunde, Lone ; Sutter, Christian ; Tan, Yen Y ; Teixeira, Manuel R ; Teo, Soo Hwang ; Thomassen, Mads ; Tibiletti, Maria Grazia ; Tischkowitz, Marc ; Tognazzo, Silvia ; Toland, Amanda E ; Tommasi, Stefania ; Torres, Diana ; Toss, Angela ; Trainer, Alison H ; Tung, Nadine ; van Asperen, Christi J ; van der Baan, Frederieke H ; van der Kolk, Lizet E ; van der Luijt, Rob B ; van Hest, Liselotte P ; Varesco, Liliana ; Varon-Mateeva, Raymonda ; Viel, Alessandra ; Vierstraete, Jeroen ; Villa, Roberta ; von Wachenfeldt, Anna ; Wagner, Philipp ; Wang-Gohrke, Shan ; Wappenschmidt, Barbara ; Weitzel, Jeffrey N ; Wieme, Greet ; Yadav, Siddhartha ; Yannoukakos, Drakoulis ; Yoon, Sook-Yee ; Zanzottera, Cristina ; Zorn, Kristin K ; D'Amico, Anthony V ; Freedman, Matthew L ; Pomerantz, Mark M ; Chenevix-Trench, Georgia ; Antoniou, Antonis C ; Neuhausen, Susan L ; Ottini, Laura ; Nielsen, Henriette Roed ; Rebbeck, Timothy R. / Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness. I: Cancer Research. 2020 ; Bind 80, Nr. 3. s. 624-638.

Bibtex

@article{3739c7a6069146498a45221a23e6b245,
title = "Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness",
abstract = "Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 ( BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95{\%} confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95{\%} CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95{\%} CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95{\%} CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.",
author = "Patel, {Vivek L} and Busch, {Evan L} and Friebel, {Tara M} and Angel Cronin and Goska Leslie and Lesley McGuffog and Julian Adlard and Simona Agata and Agnarsson, {Bjarni A} and Munaza Ahmed and Kristiina Aittom{\"a}ki and Elisa Alducci and Andrulis, {Irene L} and Adalgeir Arason and Norbert Arnold and Grazia Artioli and Brita Arver and Bernd Auber and Jacopo Azzollini and Judith Balma{\~n}a and Barkardottir, {Rosa B} and Barnes, {Daniel R} and Alicia Barroso and Daniel Barrowdale and Muriel Belotti and Javier Benitez and Brigitte Bertelsen and Blok, {Marinus J} and Istvan Bodrogi and Val{\'e}rie Bonadona and Bernardo Bonanni and Davide Bondavalli and Boonen, {Susanne E} and Julika Borde and Ake Borg and Bradbury, {Angela R} and Angela Brady and Carole Brewer and Joan Brunet and Bruno Buecher and Buys, {Saundra S} and Santiago Cabezas-Camarero and Trinidad Cald{\'e}s and Almuth Caliebe and Caligo, {Maria A} and Mariarosaria Calvello and Campbell, {Ian G} and Ileana Carnevali and Estela Carrasco and Chan, {Tsun L} and Chu, {Annie T W} and Chung, {Wendy K} and Claes, {Kathleen B M} and Collaborators, {Gemo Study} and Embrace Collaborators and Jackie Cook and Laura Cortesi and Couch, {Fergus J} and Daly, {Mary B} and Giuseppe Damante and Esther Darder and Rosemarie Davidson and {de la Hoya}, Miguel and {Della Puppa}, Lara and Joe Dennis and Orland D{\'i}ez and Ding, {Yuan Chun} and Nina Ditsch and Domchek, {Susan M} and Alan Donaldson and Bernd Dworniczak and Easton, {Douglas F} and Eccles, {Diana M} and Eeles, {Rosalind A} and Hans Ehrencrona and Bent Ejlertsen and Christoph Engel and Evans, {D Gareth} and Laurence Faivre and Ulrike Faust and L{\'i}dia Feliubadal{\'o} and Lenka Foretova and Florentia Fostira and George Fountzilas and Debra Frost and Vanesa Garc{\'i}a-Barber{\'a}n and Pilar Garre and Marion Gauthier-Villars and Lajos G{\'e}czi and Andrea Gehrig and Anne-Marie Gerdes and Paul Gesta and Giuseppe Giannini and Gord Glendon and Godwin, {Andrew K} and Goldgar, {David E} and Greene, {Mark H} and Gutierrez-Barrera, {Angelica M} and Eric Hahnen and Ute Hamann and Jan Hauke and Natalie Herold and Hogervorst, {Frans B L} and Ellen Honisch and Hopper, {John L} and Hulick, {Peter J} and kConFab Investigators and Hebon Investigators and Louise Izatt and Agnes Jager and Paul James and Ramunas Janavicius and Jensen, {Uffe Birk} and Jensen, {Thomas Dyrso} and Johannsson, {Oskar Th} and John, {Esther M} and Vijai Joseph and Eunyoung Kang and Karin Kast and Kiiski, {Johanna I} and Sung-Won Kim and Zisun Kim and Kwang-Pil Ko and Irene Konstantopoulou and Gero Kramer and Lotte Krogh and Kruse, {Torben A} and Ava Kwong and Mirjam Larsen and Christine Lasset and Charlotte Lautrup and Conxi L{\'a}zaro and Jihyoun Lee and Lee, {Jong Won} and Lee, {Min Hyuk} and Johannes Lemke and Fabienne Lesueur and Annelie Liljegren and Annika Lindblom and Patricia Llovet and Adria Lopez-Fern{\'a}ndez and Irene Lopez-Perolio and Victor Lorca and Loud, {Jennifer T} and Ma, {Edmond S K} and Mai, {Phuong L} and Siranoush Manoukian and Veronique Mari and Lynn Martin and Laura Matricardi and Noura Mebirouk and Veronica Medici and Meijers-Heijboer, {Hanne E J} and Alfons Meindl and Mensenkamp, {Arjen R} and Clare Miller and {Molina Gomes}, Denise and Marco Montagna and Mooij, {Thea M} and Lidia Moserle and Emmanuelle Mouret-Fourme and Mulligan, {Anna Marie} and Nathanson, {Katherine L} and Marie Navratilova and Heli Nevanlinna and Dieter Niederacher and {Cilius Nielsen}, {Finn C} and Liene Nikitina-Zake and Kenneth Offit and Edith Olah and Olopade, {Olufunmilayo I} and Kai-Ren Ong and Ana Osorio and Claus-Eric Ott and Domenico Palli and Park, {Sue K} and Parsons, {Michael T} and Pedersen, {Inge Sokilde} and Bernard Peissel and Ana Peixoto and Pedro P{\'e}rez-Segura and Paolo Peterlongo and {H{\o}gh Petersen}, Annabeth and Porteous, {Mary E} and Pujana, {Miguel Angel} and Paolo Radice and Juliane Ramser and Johanna Rantala and Rashid, {Muhammad U} and Kerstin Rhiem and Piera Rizzolo and Robson, {Mark E} and Rookus, {Matti A} and Rossing, {Caroline Maria} and Ruddy, {Kathryn J} and Catarina Santos and Claire Saule and Rosa Scarpitta and Schmutzler, {Rita K} and H{\'e}l{\`e}ne Schuster and Leigha Senter and Seynaeve, {Caroline M} and Shah, {Payal D} and Priyanka Sharma and Shin, {Vivian Y} and Valentina Silvestri and Jacques Simard and Singer, {Christian F} and Anne-Bine Skytte and Katie Snape and Solano, {Angela R} and Penny Soucy and Southey, {Melissa C} and Spurdle, {Amanda B} and Linda Steele and Doris Steinemann and Dominique Stoppa-Lyonnet and Agostina Stradella and Lone Sunde and Christian Sutter and Tan, {Yen Y} and Teixeira, {Manuel R} and Teo, {Soo Hwang} and Mads Thomassen and Tibiletti, {Maria Grazia} and Marc Tischkowitz and Silvia Tognazzo and Toland, {Amanda E} and Stefania Tommasi and Diana Torres and Angela Toss and Trainer, {Alison H} and Nadine Tung and {van Asperen}, {Christi J} and {van der Baan}, {Frederieke H} and {van der Kolk}, {Lizet E} and {van der Luijt}, {Rob B} and {van Hest}, {Liselotte P} and Liliana Varesco and Raymonda Varon-Mateeva and Alessandra Viel and Jeroen Vierstraete and Roberta Villa and {von Wachenfeldt}, Anna and Philipp Wagner and Shan Wang-Gohrke and Barbara Wappenschmidt and Weitzel, {Jeffrey N} and Greet Wieme and Siddhartha Yadav and Drakoulis Yannoukakos and Sook-Yee Yoon and Cristina Zanzottera and Zorn, {Kristin K} and D'Amico, {Anthony V} and Freedman, {Matthew L} and Pomerantz, {Mark M} and Georgia Chenevix-Trench and Antoniou, {Antonis C} and Neuhausen, {Susan L} and Laura Ottini and Nielsen, {Henriette Roed} and Rebbeck, {Timothy R}",
note = "{\circledC}2019 American Association for Cancer Research.",
year = "2020",
month = "2",
day = "1",
doi = "10.1158/0008-5472.CAN-19-1840",
language = "English",
volume = "80",
pages = "624--638",
journal = "Journal of Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research (A A C R)",
number = "3",

}

RIS

TY - JOUR

T1 - Association of Genomic Domains in BRCA1 and BRCA2 with Prostate Cancer Risk and Aggressiveness

AU - Patel, Vivek L

AU - Busch, Evan L

AU - Friebel, Tara M

AU - Cronin, Angel

AU - Leslie, Goska

AU - McGuffog, Lesley

AU - Adlard, Julian

AU - Agata, Simona

AU - Agnarsson, Bjarni A

AU - Ahmed, Munaza

AU - Aittomäki, Kristiina

AU - Alducci, Elisa

AU - Andrulis, Irene L

AU - Arason, Adalgeir

AU - Arnold, Norbert

AU - Artioli, Grazia

AU - Arver, Brita

AU - Auber, Bernd

AU - Azzollini, Jacopo

AU - Balmaña, Judith

AU - Barkardottir, Rosa B

AU - Barnes, Daniel R

AU - Barroso, Alicia

AU - Barrowdale, Daniel

AU - Belotti, Muriel

AU - Benitez, Javier

AU - Bertelsen, Brigitte

AU - Blok, Marinus J

AU - Bodrogi, Istvan

AU - Bonadona, Valérie

AU - Bonanni, Bernardo

AU - Bondavalli, Davide

AU - Boonen, Susanne E

AU - Borde, Julika

AU - Borg, Ake

AU - Bradbury, Angela R

AU - Brady, Angela

AU - Brewer, Carole

AU - Brunet, Joan

AU - Buecher, Bruno

AU - Buys, Saundra S

AU - Cabezas-Camarero, Santiago

AU - Caldés, Trinidad

AU - Caliebe, Almuth

AU - Caligo, Maria A

AU - Calvello, Mariarosaria

AU - Campbell, Ian G

AU - Carnevali, Ileana

AU - Carrasco, Estela

AU - Chan, Tsun L

AU - Chu, Annie T W

AU - Chung, Wendy K

AU - Claes, Kathleen B M

AU - Collaborators, Gemo Study

AU - Collaborators, Embrace

AU - Cook, Jackie

AU - Cortesi, Laura

AU - Couch, Fergus J

AU - Daly, Mary B

AU - Damante, Giuseppe

AU - Darder, Esther

AU - Davidson, Rosemarie

AU - de la Hoya, Miguel

AU - Della Puppa, Lara

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N1 - ©2019 American Association for Cancer Research.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 ( BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.

AB - Pathogenic sequence variants (PSV) in BRCA1 or BRCA2 ( BRCA1/2) are associated with increased risk and severity of prostate cancer. We evaluated whether PSVs in BRCA1/2 were associated with risk of overall prostate cancer or high grade (Gleason 8+) prostate cancer using an international sample of 65 BRCA1 and 171 BRCA2 male PSV carriers with prostate cancer, and 3,388 BRCA1 and 2,880 BRCA2 male PSV carriers without prostate cancer. PSVs in the 3' region of BRCA2 (c.7914+) were significantly associated with elevated risk of prostate cancer compared with reference bin c.1001-c.7913 [HR = 1.78; 95% confidence interval (CI), 1.25-2.52; P = 0.001], as well as elevated risk of Gleason 8+ prostate cancer (HR = 3.11; 95% CI, 1.63-5.95; P = 0.001). c.756-c.1000 was also associated with elevated prostate cancer risk (HR = 2.83; 95% CI, 1.71-4.68; P = 0.00004) and elevated risk of Gleason 8+ prostate cancer (HR = 4.95; 95% CI, 2.12-11.54; P = 0.0002). No genotype-phenotype associations were detected for PSVs in BRCA1. These results demonstrate that specific BRCA2 PSVs may be associated with elevated risk of developing aggressive prostate cancer. SIGNIFICANCE: Aggressive prostate cancer risk in BRCA2 mutation carriers may vary according to the specific BRCA2 mutation inherited by the at-risk individual.

U2 - 10.1158/0008-5472.CAN-19-1840

DO - 10.1158/0008-5472.CAN-19-1840

M3 - Journal article

VL - 80

SP - 624

EP - 638

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0008-5472

IS - 3

ER -

ID: 58957540