Forskning
Udskriv Udskriv
Switch language
Rigshospitalet - en del af Københavns Universitetshospital
Udgivet

Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Risk of breast cancer among women with benign ovarian tumors: a Danish nationwide cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Sentinel and non-sentinel lymph node metastases in patients with microinvasive breast cancer: a nationwide study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Screening mammography: benefit of double reading by breast density

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Mortality after contralateral breast cancer in Denmark

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Pre-diagnostic changes in body mass index and mortality among breast cancer patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Computational and cellular studies reveal structural destabilization and degradation of MLH1 variants in Lynch syndrome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Detection of PMS2 Mutations by Screening Hereditary Nonpolyposis Colon Cancer Families from Denmark and Sweden

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Estimating CDKN2A mutation carrier probability among global familial melanoma cases using GenoMELPREDICT

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Yosr Hamdi
  • Penny Soucy
  • Karoline B Kuchenbaeker
  • Tomi Pastinen
  • Arnaud Droit
  • Audrey Lemaçon
  • Julian Adlard
  • Kristiina Aittomäki
  • Irene L Andrulis
  • Adalgeir Arason
  • Norbert Arnold
  • Banu K Arun
  • Jacopo Azzollini
  • Anita Bane
  • Laure Barjhoux
  • Daniel Barrowdale
  • Javier Benitez
  • Pascaline Berthet
  • Marinus J Blok
  • Kristie Bobolis
  • Valérie Bonadona
  • Bernardo Bonanni
  • Angela R Bradbury
  • Carole Brewer
  • Bruno Buecher
  • Saundra S Buys
  • Maria A Caligo
  • Jocelyne Chiquette
  • Wendy K Chung
  • Kathleen B M Claes
  • Mary B Daly
  • Francesca Damiola
  • Rosemarie Davidson
  • Miguel De la Hoya
  • Kim De Leeneer
  • Orland Diez
  • Yuan Chun Ding
  • Riccardo Dolcetti
  • Susan M Domchek
  • Cecilia M Dorfling
  • Diana Eccles
  • Ros Eeles
  • Zakaria Einbeigi
  • Bent Ejlertsen
  • Christoph Engel
  • D Gareth Evans
  • Lidia Feliubadalo
  • Anne-Marie Gerdes
  • Thomas V O Hansen
  • Ida Marie Heeholm Sønderstrup
  • EMBRACE
Vis graf over relationer

PURPOSE: Cis-acting regulatory SNPs resulting in differential allelic expression (DAE) may, in part, explain the underlying phenotypic variation associated with many complex diseases. To investigate whether common variants associated with DAE were involved in breast cancer susceptibility among BRCA1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways.

METHODS: Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2.

RESULTS: We identified a region on 11q22.3 that is significantly associated with breast cancer risk in BRCA1 mutation carriers (most significant SNP rs228595 p = 7 × 10(-6)). This association was absent in BRCA2 carriers (p = 0.57). The 11q22.3 region notably encompasses genes such as ACAT1, NPAT, and ATM. Expression quantitative trait loci associations were observed in both normal breast and tumors across this region, namely for ACAT1, ATM, and other genes. In silico analysis revealed some overlap between top risk-associated SNPs and relevant biological features in mammary cell data, which suggests potential functional significance.

CONCLUSION: We identified 11q22.3 as a new modifier locus in BRCA1 carriers. Replication in larger studies using estrogen receptor (ER)-negative or triple-negative (i.e., ER-, progesterone receptor-, and HER2-negative) cases could therefore be helpful to confirm the association of this locus with breast cancer risk.

OriginalsprogEngelsk
TidsskriftBreast Cancer Research and Treatment
Vol/bind161
Udgave nummer1
Sider (fra-til)117-134
ISSN0167-6806
DOI
StatusUdgivet - jan. 2017

ID: 49234321